Incidental Mutation 'R6842:Fgfr1op2'
Institutional Source Beutler Lab
Gene Symbol Fgfr1op2
Ensembl Gene ENSMUSG00000040242
Gene NameFGFR1 oncogene partner 2
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.581) question?
Stock #R6842 (G1)
Quality Score225.009
Status Not validated
Chromosomal Location146577203-146599198 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 146590038 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107292 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037836] [ENSMUST00000058245] [ENSMUST00000067404] [ENSMUST00000111663]
Predicted Effect probably null
Transcript: ENSMUST00000037836
SMART Domains Protein: ENSMUSP00000037316
Gene: ENSMUSG00000040242

Pfam:DUF837 1 142 4e-59 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000058245
SMART Domains Protein: ENSMUSP00000107289
Gene: ENSMUSG00000040242

Pfam:DUF837 1 142 4e-59 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000067404
SMART Domains Protein: ENSMUSP00000098352
Gene: ENSMUSG00000040242

Pfam:DUF837 1 185 8.6e-80 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000111663
SMART Domains Protein: ENSMUSP00000107292
Gene: ENSMUSG00000040242

Pfam:DUF837 2 221 2e-73 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700061G19Rik A G 17: 56,877,432 N69S probably benign Het
9130011E15Rik A G 19: 45,818,977 V660A probably benign Het
Adgrl3 C T 5: 81,741,080 A1042V probably damaging Het
Armc4 C T 18: 7,268,401 D373N probably benign Het
C1s2 T A 6: 124,627,502 H395L probably benign Het
Cacna1e A G 1: 154,483,117 I307T probably damaging Het
Cap2 T C 13: 46,646,625 S381P probably damaging Het
Cbfa2t2 A G 2: 154,524,045 T392A probably benign Het
Ccdc127 T C 13: 74,356,969 I212T probably damaging Het
Cela3a A G 4: 137,405,668 V91A probably benign Het
Cep85 C G 4: 134,155,856 A241P probably benign Het
Csmd2 T C 4: 128,509,159 F2347L possibly damaging Het
Ddx19a A G 8: 110,978,625 V288A possibly damaging Het
Fbxl5 T C 5: 43,773,586 E53G probably damaging Het
Fbxw26 A T 9: 109,724,920 I217N probably damaging Het
Ighv1-37 A T 12: 114,896,655 I6N probably damaging Het
Klhdc10 T C 6: 30,439,782 L128P probably damaging Het
Lypla1 C T 1: 4,832,340 S24F probably benign Het
Mme T A 3: 63,362,044 D591E probably damaging Het
Mmp1b T A 9: 7,384,888 I254F probably damaging Het
Msr1 T C 8: 39,632,825 M5V probably benign Het
Myh8 A G 11: 67,284,655 D312G probably damaging Het
Nav2 T C 7: 49,458,169 Y709H possibly damaging Het
Oas1g T C 5: 120,887,558 E2G probably benign Het
Ocm T A 5: 144,025,691 I6F unknown Het
Olfr160 T C 9: 37,711,589 N230S probably benign Het
Olfr275 T C 4: 52,825,576 Y60H probably damaging Het
Olfr693 T C 7: 106,677,886 Y200C probably damaging Het
Olfr870 A G 9: 20,171,253 L106P possibly damaging Het
Pax1 A G 2: 147,373,720 D419G probably benign Het
Plbd1 T A 6: 136,635,614 I194F probably benign Het
Prdx6 A T 1: 161,247,370 C47S probably damaging Het
Sec24d T C 3: 123,343,219 S534P probably benign Het
Sgk3 T C 1: 9,898,754 V452A probably benign Het
Sipa1l1 T C 12: 82,420,546 V1177A probably benign Het
Tgfbr1 T C 4: 47,383,757 C32R probably damaging Het
Trim66 T C 7: 109,460,776 N801S probably benign Het
Utp6 C T 11: 79,940,949 S504N probably benign Het
Wdsub1 A C 2: 59,878,188 S114A probably benign Het
Wfikkn2 T C 11: 94,238,040 E425G probably damaging Het
Zfp956 C T 6: 47,963,829 T374I possibly damaging Het
Other mutations in Fgfr1op2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02591:Fgfr1op2 APN 6 146588846 missense probably damaging 0.97
IGL02626:Fgfr1op2 APN 6 146590011 missense probably benign 0.37
IGL03081:Fgfr1op2 APN 6 146597319 missense probably damaging 0.98
R1381:Fgfr1op2 UTSW 6 146588741 missense probably damaging 1.00
R3740:Fgfr1op2 UTSW 6 146595233 missense possibly damaging 0.94
R3934:Fgfr1op2 UTSW 6 146595171 splice site probably benign
R5471:Fgfr1op2 UTSW 6 146597362 unclassified probably null
R6988:Fgfr1op2 UTSW 6 146589965 missense probably damaging 0.99
Predicted Primers PCR Primer

Sequencing Primer
Posted On2018-09-12