|Institutional Source||Beutler Lab|
|Gene Name||LSM1 homolog, mRNA degradation associated|
|Is this an essential gene?||Probably non essential (E-score: 0.233)|
|Stock #||R6813 (G1)|
|Chromosomal Location||25785288-25803975 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to G at 25793693 bp (GRCm38)|
|Amino Acid Change||Histidine to Glutamine at position 44 (H44Q)|
|Ref Sequence||ENSEMBL: ENSMUSP00000041022 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038421] [ENSMUST00000211168] [ENSMUST00000211670]|
AA Change: H44Q
PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
AA Change: H44Q
|Meta Mutation Damage Score||0.0846|
|Coding Region Coverage||
|Validation Efficiency||100% (61/61)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Lsm1||
(F):5'- ACAGCAGAGTCGGAAATGCTC -3'
(R):5'- GCTTGGTAAATTGGAAAGCAGC -3'
(F):5'- CAGCAGAGTCGGAAATGCTCTTTAC -3'
(R):5'- TTGGAAAGCAGCAGCCAAC -3'