Incidental Mutation 'IGL01015:Fcgr4'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcgr4
Ensembl Gene ENSMUSG00000059089
Gene NameFc receptor, IgG, low affinity IV
Synonyms4833442P21Rik, FcgammaRIV, Fcgr3a, CD16-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL01015
Quality Score
Chromosomal Location171018920-171029761 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 171025789 bp
Amino Acid Change Serine to Glycine at position 188 (S188G)
Ref Sequence ENSEMBL: ENSMUSP00000077873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078825]
Predicted Effect possibly damaging
Transcript: ENSMUST00000078825
AA Change: S188G

PolyPhen 2 Score 0.720 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000077873
Gene: ENSMUSG00000059089
AA Change: S188G

signal peptide 1 20 N/A INTRINSIC
IG 31 104 5.79e-9 SMART
IG 112 188 1.44e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083971
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik T C 7: 28,155,318 C1790R probably damaging Het
Ano4 A G 10: 89,035,099 Y238H probably damaging Het
Apol7a T C 15: 77,389,855 probably benign Het
Cacna1d A T 14: 30,051,742 probably benign Het
Col12a1 A G 9: 79,633,741 V2368A probably damaging Het
Creb3l4 A G 3: 90,242,831 M1T probably null Het
Dpys T C 15: 39,846,649 D128G probably damaging Het
Ero1lb A G 13: 12,601,734 probably null Het
Fry A G 5: 150,422,787 D1587G probably benign Het
Gm43638 T A 5: 87,486,614 R45* probably null Het
Gm7647 T A 5: 94,963,887 C152S probably benign Het
Golga3 T G 5: 110,187,717 M299R probably benign Het
Iqub A T 6: 24,501,006 probably benign Het
Irak3 A T 10: 120,142,790 Y493* probably null Het
Jakmip1 G T 5: 37,085,406 E13* probably null Het
Morc3 G A 16: 93,862,646 C446Y probably damaging Het
Mroh2b G A 15: 4,941,542 D1010N probably damaging Het
Olfr1034 A T 2: 86,046,652 M57L possibly damaging Het
Olfr1388 T A 11: 49,444,374 N174K probably damaging Het
Olfr301 A G 7: 86,412,790 T184A probably damaging Het
Pkhd1 G A 1: 20,523,258 H1544Y possibly damaging Het
Rps2-ps10 C T 18: 61,259,825 probably benign Het
Smco1 T C 16: 32,274,069 V186A probably damaging Het
Snx1 C T 9: 66,094,431 E314K possibly damaging Het
Timd2 T C 11: 46,676,343 Y255C probably benign Het
Tnc A T 4: 64,017,334 I455K probably benign Het
Tsc22d1 A G 14: 76,418,741 I31V possibly damaging Het
Tyk2 A G 9: 21,120,700 S360P probably benign Het
Uroc1 G T 6: 90,358,901 probably benign Het
Vmn1r122 A T 7: 21,133,836 V98E probably damaging Het
Other mutations in Fcgr4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0193:Fcgr4 UTSW 1 171025760 missense possibly damaging 0.76
R0526:Fcgr4 UTSW 1 171029191 missense probably damaging 0.98
R1164:Fcgr4 UTSW 1 171029170 missense possibly damaging 0.75
R1544:Fcgr4 UTSW 1 171019954 missense probably damaging 1.00
R1716:Fcgr4 UTSW 1 171020103 missense probably damaging 1.00
R1905:Fcgr4 UTSW 1 171029305 missense probably damaging 0.99
R6012:Fcgr4 UTSW 1 171025664 missense possibly damaging 0.80
R6043:Fcgr4 UTSW 1 171020130 missense probably damaging 1.00
R6333:Fcgr4 UTSW 1 171029269 missense probably damaging 0.97
R7034:Fcgr4 UTSW 1 171020088 missense probably benign 0.00
R7036:Fcgr4 UTSW 1 171020088 missense probably benign 0.00
Posted On2013-06-28