|Institutional Source||Beutler Lab|
|Gene Name||ATP binding cassette subfamily G member 3|
|Essential gene?||Probably non essential (E-score: 0.061)|
|Stock #||R6814 (G1)|
|Chromosomal Location||104935057-104982718 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 104935994 bp (GRCm38)|
|Amino Acid Change||Threonine to Alanine at position 637 (T637A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000031239 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031239] [ENSMUST00000130644]|
AA Change: T637A
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: T637A
|Coding Region Coverage||
|Validation Efficiency||100% (48/48)|
|MGI Phenotype||FUNCTION: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Abcg3||
(F):5'- GATGAGGGATCCAGTCTTATGC -3'
(R):5'- TTAAGGGAAGCAACAGTGAATCTAC -3'
(F):5'- TGTGAGCAGCCATAAGTCTC -3'
(R):5'- TTGATCTCTCATCGTGGG -3'