Incidental Mutation 'R6814:Vamp5'
Institutional Source Beutler Lab
Gene Symbol Vamp5
Ensembl Gene ENSMUSG00000073002
Gene Namevesicle-associated membrane protein 5
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.311) question?
Stock #R6814 (G1)
Quality Score114.008
Status Validated
Chromosomal Location72368794-72380468 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) G to A at 72380441 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145955 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059983] [ENSMUST00000074231] [ENSMUST00000101285] [ENSMUST00000142613]
Predicted Effect probably benign
Transcript: ENSMUST00000059983
SMART Domains Protein: ENSMUSP00000059501
Gene: ENSMUSG00000050732

Pfam:Synaptobrevin 9 97 1.5e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000074231
SMART Domains Protein: ENSMUSP00000073852
Gene: ENSMUSG00000073002

Pfam:Synaptobrevin 2 90 1.6e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000101285
SMART Domains Protein: ENSMUSP00000098843
Gene: ENSMUSG00000073002

Pfam:Synaptobrevin 2 90 1.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142613
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.6%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 G A 4: 144,623,180 V336I probably benign Het
Abca7 G A 10: 80,002,999 V669I probably damaging Het
Abcg3 T C 5: 104,935,994 T637A probably benign Het
Afap1l1 A T 18: 61,733,741 V749E probably benign Het
Arfgef3 A G 10: 18,595,019 L1666S probably damaging Het
Atp2b1 A G 10: 99,023,015 N284D possibly damaging Het
Ccdc24 T C 4: 117,869,926 T196A probably benign Het
Cdc20b G A 13: 113,083,975 G463S probably damaging Het
Ceacam5 A T 7: 17,752,287 R570* probably null Het
Cit G A 5: 115,884,963 C283Y probably damaging Het
Cpa5 A T 6: 30,614,054 Q65L probably benign Het
Cspg4 A G 9: 56,890,340 I1363V possibly damaging Het
D2hgdh C A 1: 93,835,303 T270N possibly damaging Het
Dnah8 G T 17: 30,762,679 L3058F probably damaging Het
Dnajb8 A G 6: 88,223,040 N186S probably damaging Het
Dock4 T C 12: 40,812,326 probably null Het
Ear6 A G 14: 51,854,428 Y144C probably damaging Het
Fam53a T C 5: 33,610,485 Y27C probably benign Het
Fgf2 A G 3: 37,404,711 K85E probably damaging Het
Fubp1 A T 3: 152,226,146 Q37L probably benign Het
Gabra2 G T 5: 71,094,539 P22T probably damaging Het
Gm10401 T C 5: 115,098,186 probably benign Het
Gm436 A T 4: 144,670,646 L172* probably null Het
Gm6657 T A 12: 78,197,367 D31E probably damaging Het
Iglv3 A G 16: 19,241,284 I98T probably damaging Het
Nlrp2 C T 7: 5,308,710 R922H probably benign Het
Nr1h4 T C 10: 89,454,745 T474A probably damaging Het
Pcdhb20 A C 18: 37,506,165 E581D probably benign Het
Pidd1 G T 7: 141,439,418 T750K probably benign Het
Pigq A T 17: 25,931,656 probably benign Het
Rab44 A G 17: 29,139,810 E324G probably benign Het
Slc17a2 T C 13: 23,822,389 I466T possibly damaging Het
Slc24a3 C T 2: 145,616,710 Q537* probably null Het
Slc7a10 T C 7: 35,195,264 V116A probably damaging Het
Taf15 T A 11: 83,499,089 N228K probably damaging Het
Tbx19 A T 1: 165,147,633 probably null Het
Tgoln1 A G 6: 72,615,555 V314A possibly damaging Het
Them4 A T 3: 94,324,371 I172F probably damaging Het
Tmc7 T A 7: 118,547,623 Y477F probably benign Het
Tmem132a A G 19: 10,863,305 L421P probably damaging Het
Vmn2r11 T G 5: 109,047,110 R783S possibly damaging Het
Zfp180 G T 7: 24,105,881 C575F probably damaging Het
Zfp189 A T 4: 49,529,026 N43I probably damaging Het
Zfp36l2 A G 17: 84,186,093 probably benign Het
Zfp592 T C 7: 81,023,828 V180A probably benign Het
Zfp605 C T 5: 110,127,445 P143L probably benign Het
Zfp646 T C 7: 127,883,333 S1561P probably benign Het
Other mutations in Vamp5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0782:Vamp5 UTSW 6 72369470 missense probably damaging 0.97
R2937:Vamp5 UTSW 6 72369340 missense probably benign 0.20
R2938:Vamp5 UTSW 6 72369340 missense probably benign 0.20
R4894:Vamp5 UTSW 6 72370198 missense possibly damaging 0.93
R6813:Vamp5 UTSW 6 72380441 unclassified probably benign
R6825:Vamp5 UTSW 6 72380441 unclassified probably benign
R6853:Vamp5 UTSW 6 72380441 unclassified probably benign
R6858:Vamp5 UTSW 6 72380441 unclassified probably benign
R8073:Vamp5 UTSW 6 72380453 unclassified probably benign
R8354:Vamp5 UTSW 6 72370393 start gained probably benign
R8454:Vamp5 UTSW 6 72370393 start gained probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On2018-09-12