Mutagenetix > Incidental Mutation

Incidental Mutation 'R6827:Lrrc10'

534214

Institutional Source

Beutler Lab

Gene Symbol

Lrrc10

Ensembl Gene

ENSMUSG00000060187

Gene Name

leucine rich repeat containing 10

Synonyms

D330003I11Rik, Hrlrrp, Serdin1

MMRRC Submission

044938-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6827 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

116881246-116882673 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 116881545 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 73 (Q73R)

Ref Sequence

ENSEMBL: ENSMUSP00000073502 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073834]

AlphaFold

Q8K3W2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000073834
AA Change: Q73R

PolyPhen 2 Score 0.788 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000073502
Gene: ENSMUSG00000060187
AA Change: Q73R

Domain	Start	End	E-Value	Type
LRR	51	73	3.75e0	SMART
LRR	74	95	2.2e1	SMART
LRR	97	119	2.76e1	SMART
LRR_TYP	120	143	1.92e-2	SMART
LRR	166	189	1.62e0	SMART
low complexity region	265	274	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.2%

Validation Efficiency

97% (36/37)

MGI Phenotype

PHENOTYPE: Mice homozygous for a null mutation are viable and fertile. They show prenatal systolic dysfunction and development of dilated cardiomyopathy in postnatal life. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgef26	C	A	3: 62,330,919 (GRCm39)		probably null	Het
Asb3	A	G	11: 31,051,211 (GRCm39)	N555S	probably benign	Het
Bcr	T	C	10: 74,966,896 (GRCm39)	V501A	probably damaging	Het
Cchcr1	A	G	17: 35,841,302 (GRCm39)	T773A	possibly damaging	Het
Dmxl1	C	T	18: 50,054,091 (GRCm39)	P2566S	probably damaging	Het
Dscam	T	A	16: 96,840,191 (GRCm39)	N139Y	probably damaging	Het
Ephx1	A	G	1: 180,817,453 (GRCm39)	L406P	probably damaging	Het
Fbxl13	T	A	5: 21,727,176 (GRCm39)	I607F	probably damaging	Het
Gm3573	T	A	14: 42,010,429 (GRCm39)	T59S	probably benign	Het
Gm572	T	C	4: 148,742,543 (GRCm39)	L94P	possibly damaging	Het
Gypa	A	T	8: 81,231,417 (GRCm39)	M109L	probably benign	Het
Hk3	C	A	13: 55,159,165 (GRCm39)	V409L	probably damaging	Het
Kcnh6	A	G	11: 105,899,925 (GRCm39)	T65A	probably benign	Het
Kdr	G	T	5: 76,105,205 (GRCm39)	P1055Q	probably damaging	Het
Lef1	T	C	3: 130,994,053 (GRCm39)		probably null	Het
Moxd1	C	T	10: 24,155,748 (GRCm39)	T284I	probably benign	Het
Naf1	A	T	8: 67,330,343 (GRCm39)	T290S	possibly damaging	Het
Naip5	C	A	13: 100,382,437 (GRCm39)	V91L	possibly damaging	Het
Ncaph2	T	C	15: 89,255,530 (GRCm39)	V568A	probably damaging	Het
Ntrk2	T	C	13: 59,274,382 (GRCm39)	W753R	probably damaging	Het
Or51v15-ps1	C	A	7: 103,279,032 (GRCm39)	C45F	possibly damaging	Het
Pbld1	C	A	10: 62,903,212 (GRCm39)	N96K	probably damaging	Het
Pcdhac2	G	A	18: 37,277,706 (GRCm39)	V229M	probably benign	Het
Prrc2b	G	T	2: 32,090,963 (GRCm39)	R445L	probably benign	Het
Scyl2	T	C	10: 89,505,666 (GRCm39)		probably null	Het
Sdf2l1	C	G	16: 16,950,158 (GRCm39)	R6P	probably benign	Het
Slc22a5	A	T	11: 53,762,442 (GRCm39)	I21N	possibly damaging	Het
Tex51	C	T	18: 32,591,713 (GRCm39)	W186*	probably null	Het
Tmem168	A	T	6: 13,582,837 (GRCm39)	F297L	probably damaging	Het
Trpm4	T	C	7: 44,968,052 (GRCm39)	E293G	possibly damaging	Het
Trps1	T	A	15: 50,685,959 (GRCm39)	T69S	probably benign	Het
Ubxn4	T	C	1: 128,204,714 (GRCm39)	M468T	probably benign	Het
Unc5b	C	A	10: 60,616,011 (GRCm39)	R104L	probably benign	Het
Wfdc3	C	T	2: 164,576,178 (GRCm39)	G38R	possibly damaging	Het
Wnt2b	A	G	3: 104,854,408 (GRCm39)	V350A	probably benign	Het
Zfp518b	T	C	5: 38,828,882 (GRCm39)	Q1041R	probably damaging	Het
Zranb1	T	C	7: 132,551,474 (GRCm39)	F68L	probably benign	Het

Other mutations in Lrrc10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01985:Lrrc10	APN	10	116,881,921 (GRCm39)	missense	probably damaging	1.00
R0077:Lrrc10	UTSW	10	116,881,419 (GRCm39)	missense	probably damaging	1.00
R0110:Lrrc10	UTSW	10	116,881,695 (GRCm39)	missense	probably damaging	1.00
R0469:Lrrc10	UTSW	10	116,881,695 (GRCm39)	missense	probably damaging	1.00
R0510:Lrrc10	UTSW	10	116,881,695 (GRCm39)	missense	probably damaging	1.00
R1293:Lrrc10	UTSW	10	116,881,838 (GRCm39)	missense	probably benign	0.02
R1642:Lrrc10	UTSW	10	116,881,788 (GRCm39)	missense	probably damaging	1.00
R3835:Lrrc10	UTSW	10	116,881,691 (GRCm39)	missense	possibly damaging	0.75
R4413:Lrrc10	UTSW	10	116,881,719 (GRCm39)	missense	probably damaging	1.00
R5165:Lrrc10	UTSW	10	116,881,965 (GRCm39)	missense	probably benign	0.02
R5289:Lrrc10	UTSW	10	116,881,392 (GRCm39)	missense	probably benign	0.01
R5605:Lrrc10	UTSW	10	116,881,805 (GRCm39)	missense	probably damaging	1.00
R6418:Lrrc10	UTSW	10	116,881,616 (GRCm39)	missense	probably damaging	1.00
R6916:Lrrc10	UTSW	10	116,881,454 (GRCm39)	missense	possibly damaging	0.80
R7678:Lrrc10	UTSW	10	116,881,662 (GRCm39)	missense	probably benign	0.00
R8866:Lrrc10	UTSW	10	116,881,858 (GRCm39)	missense	probably damaging	0.99
R9355:Lrrc10	UTSW	10	116,881,881 (GRCm39)	missense	probably damaging	1.00
X0020:Lrrc10	UTSW	10	116,881,335 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CGTTTCACATGGGAAACACC -3'
(R):5'- CAGTTGGATTCGAGCCACAG -3'

Sequencing Primer
(F):5'- TGGGAAACACCATCCGGG -3'
(R):5'- ATTCGAGCCACAGGGTCC -3'

Posted On

2018-09-12