Incidental Mutation 'R6830:Neil3'
ID 534353
Institutional Source Beutler Lab
Gene Symbol Neil3
Ensembl Gene ENSMUSG00000039396
Gene Name nei like 3 (E. coli)
Synonyms
MMRRC Submission 044940-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.457) question?
Stock # R6830 (G1)
Quality Score 92.0077
Status Validated
Chromosome 8
Chromosomal Location 54039902-54092100 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 54052514 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 361 (N361K)
Ref Sequence ENSEMBL: ENSMUSP00000041909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047768]
AlphaFold Q8K203
PDB Structure Crystal structure of mouse Endonuclease VIII-LIKE 3 (mNEIL3) [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000047768
AA Change: N361K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000041909
Gene: ENSMUSG00000039396
AA Change: N361K

DomainStartEndE-ValueType
low complexity region 43 54 N/A INTRINSIC
Blast:Fapy_DNA_glyco 57 137 5e-34 BLAST
H2TH 152 235 6.13e-6 SMART
ZnF_RBZ 320 344 2.28e-5 SMART
Pfam:zf-GRF 506 551 1.2e-24 PFAM
Pfam:zf-GRF 553 597 5.8e-22 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased neurogenesis following hypoxia-ischemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503B20Rik T C 3: 146,356,716 (GRCm39) D64G possibly damaging Het
Amtn T C 5: 88,525,956 (GRCm39) L40P probably damaging Het
Ano6 A G 15: 95,792,342 (GRCm39) R90G probably damaging Het
Arfgef3 A C 10: 18,540,637 (GRCm39) probably null Het
Asxl3 C T 18: 22,658,445 (GRCm39) P2152S probably benign Het
Atp7b A T 8: 22,512,381 (GRCm39) V494E probably damaging Het
Bik T A 15: 83,428,409 (GRCm39) Y146N probably benign Het
C1qtnf7 A T 5: 43,766,436 (GRCm39) I12F possibly damaging Het
Cacna1e A G 1: 154,289,720 (GRCm39) probably null Het
Ccdc168 A G 1: 44,095,890 (GRCm39) V1736A probably benign Het
Ccnj A G 19: 40,833,636 (GRCm39) E231G probably damaging Het
Cd101 T C 3: 100,901,012 (GRCm39) K1020R probably benign Het
Cdh6 C A 15: 13,044,860 (GRCm39) V421L probably benign Het
Cplane1 T C 15: 8,205,668 (GRCm39) S135P probably benign Het
Decr1 T C 4: 15,924,355 (GRCm39) probably null Het
Dmxl1 C T 18: 50,054,091 (GRCm39) P2566S probably damaging Het
Dock9 G A 14: 121,860,330 (GRCm39) P866L probably damaging Het
Epx A G 11: 87,759,452 (GRCm39) F546L probably damaging Het
Fat4 T A 3: 39,035,966 (GRCm39) M3206K probably benign Het
Fgb T C 3: 82,952,332 (GRCm39) D179G probably benign Het
Gbgt1 A G 2: 28,395,220 (GRCm39) D286G probably damaging Het
Gpn1 T A 5: 31,664,832 (GRCm39) S285R probably benign Het
Htt T A 5: 34,991,670 (GRCm39) Y1212N possibly damaging Het
Kcnj13 T C 1: 87,314,745 (GRCm39) K159R probably damaging Het
Ldb2 T A 5: 44,699,199 (GRCm39) I80F probably damaging Het
Macrod2 T A 2: 140,294,602 (GRCm39) N89K probably damaging Het
Mdga2 G A 12: 66,769,775 (GRCm39) R173C probably damaging Het
Mroh9 A G 1: 162,903,935 (GRCm39) F26L probably benign Het
Nepro A G 16: 44,551,720 (GRCm39) R193G probably damaging Het
Or52d3 T A 7: 104,229,447 (GRCm39) I198N probably damaging Het
Pclo A T 5: 14,731,113 (GRCm39) Q3205L unknown Het
Plekhm1 A T 11: 103,267,715 (GRCm39) I752N probably damaging Het
Podn T C 4: 107,878,614 (GRCm39) T273A possibly damaging Het
Prep T A 10: 44,973,597 (GRCm39) M235K probably benign Het
Ptprc A T 1: 137,999,993 (GRCm39) probably null Het
Reg2 A G 6: 78,384,625 (GRCm39) H119R possibly damaging Het
Rpe65 T C 3: 159,319,805 (GRCm39) V225A probably benign Het
Scn9a T C 2: 66,398,373 (GRCm39) D79G probably damaging Het
Slc25a23 G A 17: 57,360,804 (GRCm39) R9* probably null Het
Snai3 A G 8: 123,183,212 (GRCm39) L111P probably damaging Het
Stk38 A G 17: 29,218,981 (GRCm39) probably null Het
Stk38l A T 6: 146,668,269 (GRCm39) I115F possibly damaging Het
Tmco6 T A 18: 36,871,406 (GRCm39) probably null Het
Tollip A T 7: 141,452,451 (GRCm39) M1K probably null Het
Trim40 T C 17: 37,199,742 (GRCm39) Y112C possibly damaging Het
Ttc27 T A 17: 75,163,550 (GRCm39) Y719* probably null Het
Ubald1 T C 16: 4,697,584 (GRCm39) D6G probably damaging Het
Vmn2r59 A T 7: 41,693,171 (GRCm39) S476R probably benign Het
Wfdc3 C T 2: 164,576,178 (GRCm39) G38R possibly damaging Het
Zbtb21 C T 16: 97,753,161 (GRCm39) G402D probably damaging Het
Zfp84 A G 7: 29,475,911 (GRCm39) Y201C probably benign Het
Zswim2 T A 2: 83,770,028 (GRCm39) H62L probably damaging Het
Other mutations in Neil3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0426:Neil3 UTSW 8 54,062,431 (GRCm39) unclassified probably benign
R0533:Neil3 UTSW 8 54,091,810 (GRCm39) splice site probably null
R0943:Neil3 UTSW 8 54,062,404 (GRCm39) unclassified probably benign
R1688:Neil3 UTSW 8 54,054,069 (GRCm39) missense probably damaging 1.00
R1875:Neil3 UTSW 8 54,052,454 (GRCm39) missense probably damaging 1.00
R2238:Neil3 UTSW 8 54,052,311 (GRCm39) missense possibly damaging 0.68
R3979:Neil3 UTSW 8 54,076,699 (GRCm39) missense probably damaging 1.00
R4909:Neil3 UTSW 8 54,091,928 (GRCm39) missense probably damaging 1.00
R5069:Neil3 UTSW 8 54,054,076 (GRCm39) missense possibly damaging 0.89
R5407:Neil3 UTSW 8 54,054,054 (GRCm39) missense probably benign 0.00
R6144:Neil3 UTSW 8 54,052,447 (GRCm39) missense probably benign 0.01
R6185:Neil3 UTSW 8 54,052,182 (GRCm39) missense probably benign 0.03
R6234:Neil3 UTSW 8 54,061,774 (GRCm39) missense probably damaging 1.00
R6375:Neil3 UTSW 8 54,040,311 (GRCm39) missense possibly damaging 0.71
R7003:Neil3 UTSW 8 54,054,001 (GRCm39) missense possibly damaging 0.60
R8165:Neil3 UTSW 8 54,042,129 (GRCm39) missense probably benign 0.00
R8390:Neil3 UTSW 8 54,062,559 (GRCm39) missense probably damaging 1.00
R9166:Neil3 UTSW 8 54,058,722 (GRCm39) missense probably damaging 1.00
R9554:Neil3 UTSW 8 54,061,770 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACTGGGCACAAACTGTAGGTG -3'
(R):5'- TGAGCTTCACAGTGTACTTGTAC -3'

Sequencing Primer
(F):5'- GGGAGAAACATTTGAGATTCCCCATC -3'
(R):5'- TCACAGTGTACTTGTACATATTTGTG -3'
Posted On 2018-09-12