Incidental Mutation 'R6835:Gpr179'
ID 534409
Institutional Source Beutler Lab
Gene Symbol Gpr179
Ensembl Gene ENSMUSG00000070337
Gene Name G protein-coupled receptor 179
Synonyms 5330439C02Rik
MMRRC Submission 044944-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R6835 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 97222935-97242903 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 97238293 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 310 (F310L)
Ref Sequence ENSEMBL: ENSMUSP00000091474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093942]
AlphaFold E9PY61
Predicted Effect probably damaging
Transcript: ENSMUST00000093942
AA Change: F310L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091474
Gene: ENSMUSG00000070337
AA Change: F310L

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 28 41 N/A INTRINSIC
EGF 281 357 1.91e1 SMART
Pfam:7tm_3 391 633 3.2e-40 PFAM
low complexity region 735 759 N/A INTRINSIC
low complexity region 868 880 N/A INTRINSIC
low complexity region 896 916 N/A INTRINSIC
low complexity region 959 988 N/A INTRINSIC
low complexity region 1107 1125 N/A INTRINSIC
internal_repeat_2 1156 1467 1.99e-12 PROSPERO
internal_repeat_1 1235 1674 2.85e-27 PROSPERO
internal_repeat_2 1569 1879 1.99e-12 PROSPERO
internal_repeat_1 1756 2284 2.85e-27 PROSPERO
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit absence of b wave without retinal abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl11 A G 9: 107,807,761 (GRCm39) R695G probably benign Het
Arhgef4 A G 1: 34,845,574 (GRCm39) H1533R probably damaging Het
Birc6 T C 17: 74,949,499 (GRCm39) L3120P probably damaging Het
Cfap46 T A 7: 139,232,414 (GRCm39) I850F probably damaging Het
Crym A C 7: 119,785,868 (GRCm39) S311A probably benign Het
Cttn T C 7: 144,010,234 (GRCm39) probably null Het
Dtnb C T 12: 3,682,841 (GRCm39) probably benign Het
Edem1 T C 6: 108,831,360 (GRCm39) V607A probably benign Het
Etfa A G 9: 55,403,103 (GRCm39) V64A probably benign Het
Fam133b A G 5: 3,604,732 (GRCm39) T40A possibly damaging Het
Fmn2 C A 1: 174,527,235 (GRCm39) D1442E probably damaging Het
Gpi1 T C 7: 33,926,563 (GRCm39) K128E possibly damaging Het
Hdac7 T A 15: 97,700,628 (GRCm39) H531L probably damaging Het
Hfm1 G A 5: 107,026,681 (GRCm39) R145* probably null Het
Hsp90b1 A T 10: 86,529,949 (GRCm39) D573E probably damaging Het
Hunk T G 16: 90,269,412 (GRCm39) W243G probably damaging Het
Icam1 G T 9: 20,938,421 (GRCm39) G327W possibly damaging Het
Ino80d C A 1: 63,113,485 (GRCm39) A322S probably benign Het
Irag1 T G 7: 110,520,541 (GRCm39) E278A probably damaging Het
Itpkc A C 7: 26,927,240 (GRCm39) S225A probably benign Het
Krt75 C T 15: 101,479,472 (GRCm39) R286Q probably benign Het
Lmnb2 A G 10: 80,745,794 (GRCm39) L95P probably damaging Het
Mns1 T C 9: 72,360,026 (GRCm39) M392T probably damaging Het
Morc3 A T 16: 93,644,309 (GRCm39) N200I probably damaging Het
Myadm T C 7: 3,346,192 (GRCm39) V318A possibly damaging Het
Nt5dc1 A C 10: 34,186,375 (GRCm39) S398A probably benign Het
Or13c7 T C 4: 43,854,912 (GRCm39) V201A probably benign Het
Or1e31 A G 11: 73,690,061 (GRCm39) I174T possibly damaging Het
Pcdhga2 T C 18: 37,803,842 (GRCm39) I562T probably damaging Het
Pcdhgb1 T A 18: 37,813,553 (GRCm39) C15S probably benign Het
Pikfyve T G 1: 65,298,002 (GRCm39) L1532R probably damaging Het
Rdh7 T A 10: 127,720,608 (GRCm39) T255S probably benign Het
Rtel1 A G 2: 180,997,746 (GRCm39) T1165A probably benign Het
Sdk2 C T 11: 113,720,874 (GRCm39) A1352T probably damaging Het
Strip2 T C 6: 29,941,916 (GRCm39) S629P probably damaging Het
Taf5 A G 19: 47,065,776 (GRCm39) T494A possibly damaging Het
Tek T G 4: 94,741,671 (GRCm39) N809K possibly damaging Het
Tmbim7 A T 5: 3,711,943 (GRCm39) T63S probably benign Het
Utrn A T 10: 12,603,508 (GRCm39) L624Q probably damaging Het
Xbp1 A G 11: 5,471,809 (GRCm39) probably benign Het
Zbp1 T A 2: 173,055,704 (GRCm39) probably null Het
Zfp112 T C 7: 23,825,231 (GRCm39) C400R probably damaging Het
Zfp202 C T 9: 40,121,531 (GRCm39) probably null Het
Zfp747 T C 7: 126,973,219 (GRCm39) E317G possibly damaging Het
Other mutations in Gpr179
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Gpr179 APN 11 97,228,627 (GRCm39) missense probably damaging 0.99
IGL01152:Gpr179 APN 11 97,228,237 (GRCm39) missense probably benign 0.08
IGL01402:Gpr179 APN 11 97,229,012 (GRCm39) nonsense probably null
IGL01404:Gpr179 APN 11 97,229,012 (GRCm39) nonsense probably null
IGL01773:Gpr179 APN 11 97,232,192 (GRCm39) missense probably benign 0.05
IGL02682:Gpr179 APN 11 97,242,691 (GRCm39) missense probably benign
IGL02728:Gpr179 APN 11 97,228,726 (GRCm39) missense probably damaging 0.99
IGL03243:Gpr179 APN 11 97,242,301 (GRCm39) missense probably benign 0.02
IGL03272:Gpr179 APN 11 97,227,419 (GRCm39) missense possibly damaging 0.89
IGL03347:Gpr179 APN 11 97,242,664 (GRCm39) missense probably damaging 1.00
IGL03355:Gpr179 APN 11 97,228,434 (GRCm39) missense possibly damaging 0.57
PIT4280001:Gpr179 UTSW 11 97,234,941 (GRCm39) missense probably damaging 1.00
PIT4366001:Gpr179 UTSW 11 97,227,677 (GRCm39) missense probably benign
R0042:Gpr179 UTSW 11 97,225,757 (GRCm39) missense probably benign 0.04
R0042:Gpr179 UTSW 11 97,225,757 (GRCm39) missense probably benign 0.04
R0080:Gpr179 UTSW 11 97,242,295 (GRCm39) missense probably benign 0.08
R0255:Gpr179 UTSW 11 97,226,892 (GRCm39) missense probably benign 0.24
R0412:Gpr179 UTSW 11 97,229,633 (GRCm39) missense probably damaging 1.00
R0481:Gpr179 UTSW 11 97,240,544 (GRCm39) missense probably damaging 1.00
R0612:Gpr179 UTSW 11 97,229,264 (GRCm39) missense possibly damaging 0.86
R0786:Gpr179 UTSW 11 97,234,100 (GRCm39) missense probably damaging 1.00
R1753:Gpr179 UTSW 11 97,237,404 (GRCm39) missense probably damaging 1.00
R1761:Gpr179 UTSW 11 97,225,932 (GRCm39) missense probably benign 0.00
R1796:Gpr179 UTSW 11 97,227,382 (GRCm39) missense possibly damaging 0.86
R1969:Gpr179 UTSW 11 97,228,784 (GRCm39) missense probably benign
R2240:Gpr179 UTSW 11 97,242,559 (GRCm39) missense probably damaging 1.00
R3855:Gpr179 UTSW 11 97,232,260 (GRCm39) missense probably damaging 1.00
R3913:Gpr179 UTSW 11 97,225,591 (GRCm39) missense probably benign 0.01
R4484:Gpr179 UTSW 11 97,226,537 (GRCm39) missense probably benign 0.28
R4806:Gpr179 UTSW 11 97,240,610 (GRCm39) missense possibly damaging 0.55
R4816:Gpr179 UTSW 11 97,230,074 (GRCm39) missense probably damaging 0.99
R4906:Gpr179 UTSW 11 97,237,487 (GRCm39) missense possibly damaging 0.87
R4945:Gpr179 UTSW 11 97,240,544 (GRCm39) missense probably damaging 1.00
R5191:Gpr179 UTSW 11 97,228,975 (GRCm39) missense possibly damaging 0.76
R5273:Gpr179 UTSW 11 97,238,256 (GRCm39) missense probably damaging 1.00
R5317:Gpr179 UTSW 11 97,228,671 (GRCm39) missense probably damaging 1.00
R5459:Gpr179 UTSW 11 97,227,483 (GRCm39) missense probably benign 0.00
R5507:Gpr179 UTSW 11 97,229,156 (GRCm39) missense probably damaging 1.00
R5523:Gpr179 UTSW 11 97,227,608 (GRCm39) missense probably benign 0.37
R5536:Gpr179 UTSW 11 97,234,641 (GRCm39) missense probably damaging 1.00
R5591:Gpr179 UTSW 11 97,236,581 (GRCm39) missense probably benign 0.17
R5679:Gpr179 UTSW 11 97,227,571 (GRCm39) missense probably benign 0.20
R5738:Gpr179 UTSW 11 97,242,232 (GRCm39) missense probably damaging 1.00
R5829:Gpr179 UTSW 11 97,226,524 (GRCm39) missense probably benign 0.11
R5836:Gpr179 UTSW 11 97,229,882 (GRCm39) missense probably benign 0.03
R6007:Gpr179 UTSW 11 97,226,628 (GRCm39) nonsense probably null
R6047:Gpr179 UTSW 11 97,229,242 (GRCm39) missense probably damaging 1.00
R6339:Gpr179 UTSW 11 97,235,002 (GRCm39) missense probably damaging 1.00
R6383:Gpr179 UTSW 11 97,227,973 (GRCm39) missense possibly damaging 0.88
R6674:Gpr179 UTSW 11 97,238,231 (GRCm39) critical splice donor site probably null
R6712:Gpr179 UTSW 11 97,226,993 (GRCm39) missense possibly damaging 0.94
R6980:Gpr179 UTSW 11 97,225,684 (GRCm39) missense probably benign 0.38
R7044:Gpr179 UTSW 11 97,240,616 (GRCm39) missense probably benign 0.19
R7121:Gpr179 UTSW 11 97,225,556 (GRCm39) missense probably benign 0.00
R7307:Gpr179 UTSW 11 97,229,672 (GRCm39) missense probably benign 0.36
R7406:Gpr179 UTSW 11 97,242,420 (GRCm39) missense probably damaging 0.99
R7467:Gpr179 UTSW 11 97,226,115 (GRCm39) missense probably benign 0.02
R7477:Gpr179 UTSW 11 97,226,665 (GRCm39) missense possibly damaging 0.87
R7725:Gpr179 UTSW 11 97,242,118 (GRCm39) missense probably damaging 1.00
R8028:Gpr179 UTSW 11 97,228,627 (GRCm39) missense probably damaging 0.99
R8165:Gpr179 UTSW 11 97,242,364 (GRCm39) missense probably benign 0.12
R8262:Gpr179 UTSW 11 97,226,983 (GRCm39) missense probably benign 0.00
R8674:Gpr179 UTSW 11 97,225,873 (GRCm39) missense probably benign 0.00
R8695:Gpr179 UTSW 11 97,227,124 (GRCm39) missense possibly damaging 0.59
R8731:Gpr179 UTSW 11 97,234,555 (GRCm39) missense probably damaging 1.00
R8791:Gpr179 UTSW 11 97,242,739 (GRCm39) missense probably damaging 1.00
R8889:Gpr179 UTSW 11 97,226,590 (GRCm39) missense possibly damaging 0.95
R8892:Gpr179 UTSW 11 97,226,590 (GRCm39) missense possibly damaging 0.95
R8898:Gpr179 UTSW 11 97,242,329 (GRCm39) nonsense probably null
R8940:Gpr179 UTSW 11 97,228,675 (GRCm39) missense probably damaging 1.00
R9266:Gpr179 UTSW 11 97,227,766 (GRCm39) missense probably benign
R9332:Gpr179 UTSW 11 97,229,551 (GRCm39) missense probably damaging 1.00
R9440:Gpr179 UTSW 11 97,229,315 (GRCm39) missense probably benign 0.11
R9557:Gpr179 UTSW 11 97,235,029 (GRCm39) missense probably damaging 0.97
R9594:Gpr179 UTSW 11 97,225,727 (GRCm39) missense probably benign 0.13
R9723:Gpr179 UTSW 11 97,225,546 (GRCm39) missense possibly damaging 0.93
X0065:Gpr179 UTSW 11 97,238,264 (GRCm39) missense probably benign 0.08
Z1176:Gpr179 UTSW 11 97,227,474 (GRCm39) missense probably benign 0.05
Z1177:Gpr179 UTSW 11 97,242,065 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAAATGCCCTGCTGCTGGTC -3'
(R):5'- CGGCAGAGATGAGAAAGTTTCC -3'

Sequencing Primer
(F):5'- CTGGAACTCACTTTGTAGACCAGG -3'
(R):5'- CAGAGATGAGAAAGTTTCCAGAGG -3'
Posted On 2018-09-12