Incidental Mutation 'R6843:Zfp932'
| ID |
534617 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp932
|
| Ensembl Gene |
ENSMUSG00000066613 |
| Gene Name |
zinc finger protein 932 |
| Synonyms |
2310001H12Rik |
| MMRRC Submission |
044949-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
R6843 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
110144387-110158277 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 110156581 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 92
(M92T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000121749
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099484]
[ENSMUST00000112536]
[ENSMUST00000112540]
[ENSMUST00000125213]
[ENSMUST00000143639]
[ENSMUST00000187241]
|
| AlphaFold |
E9QAG8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099484
|
| SMART Domains |
Protein: ENSMUSP00000097083
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112536
AA Change: M60T
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000108155
Gene: ENSMUSG00000066613
AA Change: M60T
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
31 |
5e-12 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112540
AA Change: M93T
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000108159
Gene: ENSMUSG00000066613
AA Change: M93T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125213
AA Change: M60T
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000119843
Gene: ENSMUSG00000066613
AA Change: M60T
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
34 |
2e-14 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
Pfam:zf-C2H2_6
|
182 |
191 |
7.3e-1 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143639
AA Change: M92T
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000121749
Gene: ENSMUSG00000066613
AA Change: M92T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
60 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.76e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187241
AA Change: M93T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000140446
Gene: ENSMUSG00000066613
AA Change: M93T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
7.1e-17 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
4.8e-5 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
1.5e-5 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
7.2e-4 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
5.4e-7 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
4.5e-5 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
9.2e-7 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
7.5e-7 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
2.1e-6 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
4e-6 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
6.5e-6 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
6.9e-6 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
2.1e-5 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
1.1e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
A |
T |
6: 121,615,360 (GRCm39) |
Q78L |
probably benign |
Het |
| Akr1c21 |
A |
G |
13: 4,625,213 (GRCm39) |
H48R |
probably damaging |
Het |
| Anks1b |
T |
A |
10: 90,784,460 (GRCm39) |
S1143T |
probably damaging |
Het |
| Apip |
T |
G |
2: 102,922,834 (GRCm39) |
F217L |
probably benign |
Het |
| Ash1l |
T |
A |
3: 88,892,695 (GRCm39) |
Y1525N |
probably damaging |
Het |
| Bcl2l13 |
G |
A |
6: 120,825,578 (GRCm39) |
|
probably null |
Het |
| Cep85 |
C |
G |
4: 133,883,167 (GRCm39) |
A241P |
probably benign |
Het |
| Clk4 |
T |
G |
11: 51,167,076 (GRCm39) |
|
probably null |
Het |
| Cnr2 |
C |
T |
4: 135,644,900 (GRCm39) |
P326L |
probably benign |
Het |
| Cryaa |
A |
G |
17: 31,897,147 (GRCm39) |
D58G |
possibly damaging |
Het |
| Crybg3 |
G |
A |
16: 59,380,159 (GRCm39) |
T365M |
probably benign |
Het |
| Csmd2 |
A |
G |
4: 128,357,587 (GRCm39) |
N1683D |
probably benign |
Het |
| Dbx2 |
T |
G |
15: 95,552,340 (GRCm39) |
I102L |
possibly damaging |
Het |
| Dll4 |
A |
T |
2: 119,156,475 (GRCm39) |
|
probably benign |
Het |
| Epb42 |
T |
A |
2: 120,858,166 (GRCm39) |
Y264F |
possibly damaging |
Het |
| Exoc3l |
T |
A |
8: 106,016,729 (GRCm39) |
H695L |
probably benign |
Het |
| Fhip1a |
G |
A |
3: 85,580,352 (GRCm39) |
P618S |
probably damaging |
Het |
| Ghsr |
A |
C |
3: 27,426,676 (GRCm39) |
D244A |
probably benign |
Het |
| Gm9195 |
A |
G |
14: 72,678,651 (GRCm39) |
Y2268H |
possibly damaging |
Het |
| Hdac1 |
A |
G |
4: 129,436,383 (GRCm39) |
Y14H |
probably damaging |
Het |
| Hdac3 |
A |
T |
18: 38,075,007 (GRCm39) |
Y282N |
probably benign |
Het |
| Heg1 |
T |
A |
16: 33,539,896 (GRCm39) |
N285K |
probably benign |
Het |
| Igkv4-90 |
A |
G |
6: 68,784,670 (GRCm39) |
F8S |
possibly damaging |
Het |
| Map2k1 |
A |
T |
9: 64,094,973 (GRCm39) |
D336E |
probably damaging |
Het |
| Map4k2 |
A |
T |
19: 6,403,477 (GRCm39) |
I796F |
probably damaging |
Het |
| Mapk13 |
T |
A |
17: 28,994,427 (GRCm39) |
|
probably null |
Het |
| Mprip |
A |
G |
11: 59,650,554 (GRCm39) |
I1419M |
possibly damaging |
Het |
| Nrap |
T |
C |
19: 56,368,651 (GRCm39) |
E255G |
probably damaging |
Het |
| Oprl1 |
A |
G |
2: 181,357,547 (GRCm39) |
E11G |
probably damaging |
Het |
| Or1i2 |
T |
C |
10: 78,447,891 (GRCm39) |
N195D |
probably damaging |
Het |
| Or4f14 |
T |
C |
2: 111,743,260 (GRCm39) |
N5S |
probably damaging |
Het |
| Or52b3 |
A |
G |
7: 102,203,928 (GRCm39) |
I146V |
probably benign |
Het |
| Or5b99 |
G |
T |
19: 12,976,362 (GRCm39) |
C4F |
probably benign |
Het |
| Or6c209 |
A |
G |
10: 129,483,048 (GRCm39) |
D17G |
possibly damaging |
Het |
| Palmd |
T |
A |
3: 116,717,864 (GRCm39) |
D211V |
probably damaging |
Het |
| Pcdhga11 |
A |
G |
18: 37,889,378 (GRCm39) |
N129D |
probably damaging |
Het |
| Plekha6 |
T |
A |
1: 133,202,616 (GRCm39) |
M359K |
probably damaging |
Het |
| Plekha7 |
G |
T |
7: 115,742,555 (GRCm39) |
H756Q |
probably benign |
Het |
| Ppfibp2 |
C |
T |
7: 107,326,938 (GRCm39) |
P441S |
probably benign |
Het |
| Ptprk |
T |
C |
10: 28,467,978 (GRCm39) |
I1373T |
possibly damaging |
Het |
| Serpinb9g |
G |
T |
13: 33,676,900 (GRCm39) |
L227F |
probably damaging |
Het |
| Snapc4 |
C |
A |
2: 26,263,611 (GRCm39) |
A11S |
probably benign |
Het |
| Sqor |
T |
C |
2: 122,626,900 (GRCm39) |
V7A |
probably benign |
Het |
| Sqor |
G |
T |
2: 122,651,215 (GRCm39) |
G437V |
probably damaging |
Het |
| Srrm3 |
T |
C |
5: 135,881,135 (GRCm39) |
V145A |
probably benign |
Het |
| Stx1b |
G |
A |
7: 127,414,151 (GRCm39) |
Q72* |
probably null |
Het |
| Syt7 |
A |
G |
19: 10,399,135 (GRCm39) |
D77G |
probably damaging |
Het |
| Tvp23a |
G |
A |
16: 10,264,884 (GRCm39) |
A9V |
probably benign |
Het |
| Vmn1r66 |
T |
A |
7: 10,008,692 (GRCm39) |
I114F |
probably damaging |
Het |
| Vmn2r80 |
C |
A |
10: 79,005,502 (GRCm39) |
Q380K |
probably benign |
Het |
| Xdh |
C |
T |
17: 74,230,125 (GRCm39) |
E269K |
probably damaging |
Het |
|
| Other mutations in Zfp932 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0153:Zfp932
|
UTSW |
5 |
110,154,834 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0268:Zfp932
|
UTSW |
5 |
110,156,929 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1673:Zfp932
|
UTSW |
5 |
110,156,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Zfp932
|
UTSW |
5 |
110,144,489 (GRCm39) |
start gained |
probably benign |
|
|
R1893:Zfp932
|
UTSW |
5 |
110,157,069 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1942:Zfp932
|
UTSW |
5 |
110,154,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Zfp932
|
UTSW |
5 |
110,157,684 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R2076:Zfp932
|
UTSW |
5 |
110,157,334 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2329:Zfp932
|
UTSW |
5 |
110,157,406 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3944:Zfp932
|
UTSW |
5 |
110,157,820 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4551:Zfp932
|
UTSW |
5 |
110,157,505 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4679:Zfp932
|
UTSW |
5 |
110,157,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Zfp932
|
UTSW |
5 |
110,157,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5116:Zfp932
|
UTSW |
5 |
110,157,242 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5260:Zfp932
|
UTSW |
5 |
110,157,501 (GRCm39) |
nonsense |
probably null |
|
|
R5536:Zfp932
|
UTSW |
5 |
110,157,713 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Zfp932
|
UTSW |
5 |
110,157,209 (GRCm39) |
nonsense |
probably null |
|
|
R6786:Zfp932
|
UTSW |
5 |
110,157,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7437:Zfp932
|
UTSW |
5 |
110,157,880 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7496:Zfp932
|
UTSW |
5 |
110,156,694 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7704:Zfp932
|
UTSW |
5 |
110,157,630 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8224:Zfp932
|
UTSW |
5 |
110,144,480 (GRCm39) |
start gained |
probably benign |
|
|
R8317:Zfp932
|
UTSW |
5 |
110,156,922 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Zfp932
|
UTSW |
5 |
110,154,827 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8967:Zfp932
|
UTSW |
5 |
110,156,883 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9083:Zfp932
|
UTSW |
5 |
110,157,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9142:Zfp932
|
UTSW |
5 |
110,157,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9511:Zfp932
|
UTSW |
5 |
110,155,177 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9533:Zfp932
|
UTSW |
5 |
110,157,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Zfp932
|
UTSW |
5 |
110,157,064 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACCATTACAGGTATGCAAGGG -3'
(R):5'- GACAATGATGTGCAAAGGCTTTAC -3'
Sequencing Primer
(F):5'- GATGTGACTCCTCTTTACAATTAGGC -3'
(R):5'- TGGAATGCAAAGGCTTTACCAC -3'
|
| Posted On |
2018-09-12 |
Incidental Mutation