Incidental Mutation 'R6843:Olfr799'
ID534633
Institutional Source Beutler Lab
Gene Symbol Olfr799
Ensembl Gene ENSMUSG00000094734
Gene Nameolfactory receptor 799
SynonymsMOR114-2, GA_x6K02T2PULF-11325750-11326685
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #R6843 (G1)
Quality Score225.009
Status Not validated
Chromosome10
Chromosomal Location129637484-129648326 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 129647179 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 17 (D17G)
Ref Sequence ENSEMBL: ENSMUSP00000150406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071126] [ENSMUST00000213820] [ENSMUST00000214182] [ENSMUST00000216446] [ENSMUST00000217364]
Predicted Effect possibly damaging
Transcript: ENSMUST00000071126
AA Change: D17G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000071126
Gene: ENSMUSG00000094734
AA Change: D17G

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 6e-46 PFAM
Pfam:7TM_GPCR_Srsx 32 302 6e-7 PFAM
Pfam:7tm_1 38 287 7.7e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213820
AA Change: D17G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214182
AA Change: D17G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216446
AA Change: D17G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217364
AA Change: D17G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A T 6: 121,638,401 Q78L probably benign Het
Akr1c21 A G 13: 4,575,214 H48R probably damaging Het
Anks1b T A 10: 90,948,598 S1143T probably damaging Het
Apip T G 2: 103,092,489 F217L probably benign Het
Ash1l T A 3: 88,985,388 Y1525N probably damaging Het
Bcl2l13 G A 6: 120,848,617 probably null Het
Cep85 C G 4: 134,155,856 A241P probably benign Het
Clk4 T G 11: 51,276,249 probably null Het
Cnr2 C T 4: 135,917,589 P326L probably benign Het
Cryaa A G 17: 31,678,173 D58G possibly damaging Het
Crybg3 G A 16: 59,559,796 T365M probably benign Het
Csmd2 A G 4: 128,463,794 N1683D probably benign Het
Dbx2 T G 15: 95,654,459 I102L possibly damaging Het
Dll4 A T 2: 119,325,994 probably benign Het
Epb42 T A 2: 121,027,685 Y264F possibly damaging Het
Exoc3l T A 8: 105,290,097 H695L probably benign Het
Fam160a1 G A 3: 85,673,045 P618S probably damaging Het
Ghsr A C 3: 27,372,527 D244A probably benign Het
Gm9195 A G 14: 72,441,211 Y2268H possibly damaging Het
Hdac1 A G 4: 129,542,590 Y14H probably damaging Het
Hdac3 A T 18: 37,941,954 Y282N probably benign Het
Heg1 T A 16: 33,719,526 N285K probably benign Het
Igkv4-90 A G 6: 68,807,686 F8S possibly damaging Het
Map2k1 A T 9: 64,187,691 D336E probably damaging Het
Map4k2 A T 19: 6,353,447 I796F probably damaging Het
Mapk13 T A 17: 28,775,453 probably null Het
Mprip A G 11: 59,759,728 I1419M possibly damaging Het
Nrap T C 19: 56,380,219 E255G probably damaging Het
Olfr1306 T C 2: 111,912,915 N5S probably damaging Het
Olfr1357 T C 10: 78,612,057 N195D probably damaging Het
Olfr1451 G T 19: 12,998,998 C4F probably benign Het
Olfr549 A G 7: 102,554,721 I146V probably benign Het
Oprl1 A G 2: 181,715,754 E11G probably damaging Het
Palmd T A 3: 116,924,215 D211V probably damaging Het
Pcdhga11 A G 18: 37,756,325 N129D probably damaging Het
Plekha6 T A 1: 133,274,878 M359K probably damaging Het
Plekha7 G T 7: 116,143,320 H756Q probably benign Het
Ppfibp2 C T 7: 107,727,731 P441S probably benign Het
Ptprk T C 10: 28,591,982 I1373T possibly damaging Het
Serpinb9g G T 13: 33,492,917 L227F probably damaging Het
Snapc4 C A 2: 26,373,599 A11S probably benign Het
Sqor T C 2: 122,784,980 V7A probably benign Het
Sqor G T 2: 122,809,295 G437V probably damaging Het
Srrm3 T C 5: 135,852,281 V145A probably benign Het
Stx1b G A 7: 127,814,979 Q72* probably null Het
Syt7 A G 19: 10,421,771 D77G probably damaging Het
Tvp23a G A 16: 10,447,020 A9V probably benign Het
Vmn1r66 T A 7: 10,274,765 I114F probably damaging Het
Vmn2r80 C A 10: 79,169,668 Q380K probably benign Het
Xdh C T 17: 73,923,130 E269K probably damaging Het
Zfp932 T C 5: 110,008,715 M92T probably benign Het
Other mutations in Olfr799
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Olfr799 APN 10 129647437 missense probably benign 0.09
IGL01079:Olfr799 APN 10 129647374 missense possibly damaging 0.79
IGL01095:Olfr799 APN 10 129647629 missense probably benign 0.00
R0080:Olfr799 UTSW 10 129647653 missense probably benign 0.00
R0082:Olfr799 UTSW 10 129647653 missense probably benign 0.00
R0268:Olfr799 UTSW 10 129647176 missense possibly damaging 0.94
R0310:Olfr799 UTSW 10 129647731 missense probably damaging 1.00
R0315:Olfr799 UTSW 10 129647497 missense probably damaging 1.00
R0545:Olfr799 UTSW 10 129647349 missense probably damaging 1.00
R1257:Olfr799 UTSW 10 129647544 nonsense probably null
R2355:Olfr799 UTSW 10 129647842 missense probably benign 0.02
R4905:Olfr799 UTSW 10 129647923 missense possibly damaging 0.88
R5706:Olfr799 UTSW 10 129648091 splice site probably null
R5961:Olfr799 UTSW 10 129647854 missense possibly damaging 0.58
R6233:Olfr799 UTSW 10 129647296 missense probably benign 0.01
R7426:Olfr799 UTSW 10 129647158 missense probably damaging 1.00
R7507:Olfr799 UTSW 10 129647497 missense probably damaging 1.00
R7871:Olfr799 UTSW 10 129647412 missense probably benign
R8315:Olfr799 UTSW 10 129647653 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATCAGCTTCTTCACTAACCTACAG -3'
(R):5'- GACTTATCCCCAGATGATAGGCTG -3'

Sequencing Primer
(F):5'- TCTTCACTAACCTACAGTAATACAGG -3'
(R):5'- TCCCCAGATGATAGGCTGTATAG -3'
Posted On2018-09-12