|Institutional Source||Beutler Lab|
|Gene Name||5-hydroxytryptamine (serotonin) receptor 1A|
|Synonyms||5-HT1A receptor, Gpcr18|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6844 (G1)|
|Chromosomal Location||105443639-105448122 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 105444947 bp|
|Amino Acid Change||Lysine to Glutamic Acid at position 232 (K232E)|
|Ref Sequence||ENSEMBL: ENSMUSP00000022235 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022235]|
|Predicted Effect||possibly damaging
AA Change: K232E
PolyPhen 2 Score 0.943 (Sensitivity: 0.80; Specificity: 0.95)
AA Change: K232E
|Coding Region Coverage||
|Validation Efficiency||92% (36/39)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygotes for targeted null mutations show a common phenotype, including augmented anxious-like behavior in the elevated plus-maze, open-field, and novel object tests, reduced immobility in the forced-swim or tail-suspension test, and changes in density of 5-HTT binding in several brain regions. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Htr1a||
(F):5'- TCGCTCACTTGGCTCATTGG -3'
(R):5'- AAGGTGCCCTTTGGAGTTGC -3'
(F):5'- CATCCCGCCTATGCTGG -3'
(R):5'- AGTTGCCCACTCGATGCAC -3'