Incidental Mutation 'IGL01023:Gm14406'
ID53469
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm14406
Ensembl Gene ENSMUSG00000078865
Gene Namepredicted gene 14406
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01023
Quality Score
Status
Chromosome2
Chromosomal Location177569204-177578210 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 177569239 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 416 (C416S)
Ref Sequence ENSEMBL: ENSMUSP00000104573 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108943] [ENSMUST00000108945]
Predicted Effect probably benign
Transcript: ENSMUST00000108943
SMART Domains Protein: ENSMUSP00000104571
Gene: ENSMUSG00000078865

DomainStartEndE-ValueType
KRAB 4 64 1.1e-11 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108945
AA Change: C416S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104573
Gene: ENSMUSG00000078865
AA Change: C416S

DomainStartEndE-ValueType
KRAB 4 66 1.47e-12 SMART
ZnF_C2H2 78 97 2.2e2 SMART
ZnF_C2H2 103 125 7.78e-3 SMART
ZnF_C2H2 131 153 2.12e-4 SMART
ZnF_C2H2 159 181 2.43e-4 SMART
ZnF_C2H2 187 209 2.53e-2 SMART
ZnF_C2H2 215 237 4.87e-4 SMART
ZnF_C2H2 243 265 1.12e-3 SMART
ZnF_C2H2 271 293 4.54e-4 SMART
ZnF_C2H2 299 321 3.04e-5 SMART
ZnF_C2H2 327 349 4.87e-4 SMART
ZnF_C2H2 355 377 1.03e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc1 A G 2: 128,629,729 L1472P probably damaging Het
BC005561 T A 5: 104,520,500 W963R probably damaging Het
Col18a1 C T 10: 77,070,975 V1151M probably damaging Het
Crmp1 A T 5: 37,276,313 D286V probably damaging Het
Ddx60 A T 8: 61,942,514 I162F probably damaging Het
Fam24b A T 7: 131,326,174 C95* probably null Het
Fsd1 A G 17: 55,988,245 Y78C probably damaging Het
Galc C T 12: 98,231,422 V343I probably benign Het
Glis2 C T 16: 4,611,650 R214C probably damaging Het
Gm5724 A G 6: 141,754,429 S126P probably benign Het
Gnat3 T C 5: 18,003,828 S177P probably damaging Het
Higd1a C T 9: 121,849,683 G80D possibly damaging Het
Hp1bp3 T C 4: 138,240,629 V421A possibly damaging Het
Ipo11 A T 13: 106,897,259 F238L probably benign Het
Med26 A T 8: 72,495,874 F460L possibly damaging Het
Olfr1111 T A 2: 87,149,825 T279S possibly damaging Het
Osbp2 T C 11: 3,863,387 I161V probably benign Het
Prr5 T C 15: 84,699,655 V152A possibly damaging Het
Prx T A 7: 27,519,419 I1115K probably benign Het
Ptpn22 A G 3: 103,903,374 I708M probably benign Het
Robo3 T C 9: 37,429,551 T120A probably damaging Het
Setd2 C A 9: 110,547,513 S132* probably null Het
Slc9a1 A G 4: 133,422,143 E760G probably benign Het
Stx16 A T 2: 174,092,409 H135L probably damaging Het
Tas2r131 A T 6: 132,957,801 L15Q probably damaging Het
Tmcc1 A G 6: 116,043,027 L128P probably damaging Het
Tmem269 C A 4: 119,209,314 M182I probably benign Het
Tnfaip8l2 A G 3: 95,140,415 S46P probably damaging Het
Trim30c A G 7: 104,382,972 probably benign Het
Unc13a C T 8: 71,661,825 E184K probably benign Het
Wfs1 A T 5: 36,967,917 C467* probably null Het
Zfp78 G A 7: 6,375,588 G77D possibly damaging Het
Other mutations in Gm14406
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02382:Gm14406 APN 2 177569195 unclassified probably benign
Posted On2013-06-28