Incidental Mutation 'R6846:Myocos'
ID 534748
Institutional Source Beutler Lab
Gene Symbol Myocos
Ensembl Gene ENSMUSG00000091060
Gene Name myocilin opposite strand
Synonyms 7420461P10Rik
MMRRC Submission 044952-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R6846 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 162474762-162485788 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 162484665 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169439] [ENSMUST00000193898]
AlphaFold Q3UWS6
Predicted Effect unknown
Transcript: ENSMUST00000169439
AA Change: D48G
SMART Domains Protein: ENSMUSP00000127102
Gene: ENSMUSG00000091060
AA Change: D48G

DomainStartEndE-ValueType
low complexity region 101 113 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193898
SMART Domains Protein: ENSMUSP00000141822
Gene: ENSMUSG00000091060

DomainStartEndE-ValueType
low complexity region 20 32 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak A G 19: 8,989,221 (GRCm39) N3502D possibly damaging Het
Ambn T A 5: 88,609,574 (GRCm39) I94K possibly damaging Het
Ank3 A G 10: 69,660,179 (GRCm39) H227R probably damaging Het
Arhgap42 G T 9: 9,006,446 (GRCm39) P650Q probably damaging Het
Bahcc1 A G 11: 120,162,422 (GRCm39) E240G possibly damaging Het
Cd19 T C 7: 126,010,025 (GRCm39) E408G probably benign Het
Cdh11 G A 8: 103,391,276 (GRCm39) T320I probably damaging Het
Cep131 G A 11: 119,956,517 (GRCm39) R944W probably damaging Het
Dgkd T G 1: 87,853,413 (GRCm39) probably null Het
Dnaaf1 T A 8: 120,309,401 (GRCm39) L163Q probably damaging Het
Ecpas A G 4: 58,814,081 (GRCm39) C1342R possibly damaging Het
Etl4 T A 2: 20,748,919 (GRCm39) L550Q possibly damaging Het
Evpl T C 11: 116,114,633 (GRCm39) E1019G probably damaging Het
Fam120b T C 17: 15,635,091 (GRCm39) L601P probably damaging Het
Fhit C A 14: 9,763,762 (GRCm38) R172L possibly damaging Het
Hoxa6 T C 6: 52,183,523 (GRCm39) H174R possibly damaging Het
Htra4 A G 8: 25,520,561 (GRCm39) F367L probably damaging Het
Ighg2c A G 12: 113,251,930 (GRCm39) I102T unknown Het
Iws1 T C 18: 32,219,326 (GRCm39) probably benign Het
Lats2 A G 14: 57,933,591 (GRCm39) V842A probably damaging Het
Limd2 C T 11: 106,050,213 (GRCm39) M1I probably null Het
Lrp2 T A 2: 69,348,787 (GRCm39) Q728L probably damaging Het
Mcc T A 18: 44,606,707 (GRCm39) T400S possibly damaging Het
Mthfd1l A G 10: 3,997,898 (GRCm39) D623G probably damaging Het
Nat1 G T 8: 67,943,995 (GRCm39) A124S probably benign Het
Nfya A T 17: 48,702,715 (GRCm39) M62K probably benign Het
Nlgn1 A G 3: 25,490,506 (GRCm39) V378A probably damaging Het
Or52r1c T A 7: 102,735,265 (GRCm39) I175N possibly damaging Het
Or5ak22 A T 2: 85,230,861 (GRCm39) N5K probably damaging Het
Pitpnm2 T C 5: 124,269,234 (GRCm39) S463G probably benign Het
Serpinb3b T C 1: 107,082,403 (GRCm39) E287G probably benign Het
Slc16a13 T C 11: 70,108,661 (GRCm39) T390A probably benign Het
Slc7a14 A G 3: 31,278,372 (GRCm39) M411T probably damaging Het
Strn A G 17: 79,043,886 (GRCm39) F11L probably damaging Het
Swap70 T A 7: 109,854,956 (GRCm39) F85L possibly damaging Het
Tanc2 T A 11: 105,689,479 (GRCm39) W214R probably benign Het
Tenm3 T C 8: 48,729,773 (GRCm39) K1411R probably benign Het
Tmem176a G T 6: 48,820,759 (GRCm39) R116L probably damaging Het
Trim71 G T 9: 114,354,115 (GRCm39) H296Q probably damaging Het
Vmn1r67 A T 7: 10,180,840 (GRCm39) I35L probably benign Het
Vnn3 A G 10: 23,727,620 (GRCm39) T47A probably benign Het
Zscan10 A T 17: 23,824,581 (GRCm39) Q12H probably damaging Het
Other mutations in Myocos
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4808:Myocos UTSW 1 162,484,609 (GRCm39) intron probably benign
R6880:Myocos UTSW 1 162,484,602 (GRCm39) splice site probably null
R7295:Myocos UTSW 1 162,484,687 (GRCm39) missense unknown
R7483:Myocos UTSW 1 162,484,678 (GRCm39) missense unknown
R7818:Myocos UTSW 1 162,475,063 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCTCTCAGGTGCAGCTAAGAAG -3'
(R):5'- CTCCCTCATCCAGGTTTGAAG -3'

Sequencing Primer
(F):5'- GGCAGCGGATGAGTAGATTCAC -3'
(R):5'- CCAGGTTTGAAGAAATATCTGCCTC -3'
Posted On 2018-09-12