Incidental Mutation 'R6846:Ighg2c'
ID534779
Institutional Source Beutler Lab
Gene Symbol Ighg2c
Ensembl Gene ENSMUSG00000076612
Gene Nameimmunoglobulin heavy constant gamma 2C
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.126) question?
Stock #R6846 (G1)
Quality Score225.009
Status Not validated
Chromosome12
Chromosomal Location113287285-113288932 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 113288310 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 102 (I102T)
Gene Model predicted gene model for transcript(s):
Predicted Effect unknown
Transcript: ENSMUST00000103416
AA Change: I102T
SMART Domains Protein: ENSMUSP00000100212
Gene: ENSMUSG00000076612
AA Change: I102T

DomainStartEndE-ValueType
IGc1 21 91 2.4e-15 SMART
IG_like 143 218 1.64e-2 SMART
IGc1 249 322 1.97e-34 SMART
transmembrane domain 350 372 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000195192
AA Change: I102T
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak A G 19: 9,011,857 N3502D possibly damaging Het
AI314180 A G 4: 58,814,081 C1342R possibly damaging Het
Ambn T A 5: 88,461,715 I94K possibly damaging Het
Ank3 A G 10: 69,824,349 H227R probably damaging Het
Arhgap42 G T 9: 9,006,445 P650Q probably damaging Het
Bahcc1 A G 11: 120,271,596 E240G possibly damaging Het
Cd19 T C 7: 126,410,853 E408G probably benign Het
Cdh11 G A 8: 102,664,644 T320I probably damaging Het
Cep131 G A 11: 120,065,691 R944W probably damaging Het
Dgkd T G 1: 87,925,691 probably null Het
Dnaaf1 T A 8: 119,582,662 L163Q probably damaging Het
Etl4 T A 2: 20,744,108 L550Q possibly damaging Het
Evpl T C 11: 116,223,807 E1019G probably damaging Het
Fam120b T C 17: 15,414,829 L601P probably damaging Het
Fhit C A 14: 9,763,762 R172L possibly damaging Het
Hoxa6 T C 6: 52,206,543 H174R possibly damaging Het
Htra4 A G 8: 25,030,545 F367L probably damaging Het
Iws1 T C 18: 32,086,273 probably benign Het
Lats2 A G 14: 57,696,134 V842A probably damaging Het
Limd2 C T 11: 106,159,387 M1I probably null Het
Lrp2 T A 2: 69,518,443 Q728L probably damaging Het
Mcc T A 18: 44,473,640 T400S possibly damaging Het
Mthfd1l A G 10: 4,047,898 D623G probably damaging Het
Myocos T C 1: 162,657,096 probably benign Het
Nat1 G T 8: 67,491,343 A124S probably benign Het
Nfya A T 17: 48,395,687 M62K probably benign Het
Nlgn1 A G 3: 25,436,342 V378A probably damaging Het
Olfr584 T A 7: 103,086,058 I175N possibly damaging Het
Olfr992 A T 2: 85,400,517 N5K probably damaging Het
Pitpnm2 T C 5: 124,131,171 S463G probably benign Het
Serpinb3b T C 1: 107,154,673 E287G probably benign Het
Slc16a13 T C 11: 70,217,835 T390A probably benign Het
Slc7a14 A G 3: 31,224,223 M411T probably damaging Het
Strn A G 17: 78,736,457 F11L probably damaging Het
Swap70 T A 7: 110,255,749 F85L possibly damaging Het
Tanc2 T A 11: 105,798,653 W214R probably benign Het
Tenm3 T C 8: 48,276,738 K1411R probably benign Het
Tmem176a G T 6: 48,843,825 R116L probably damaging Het
Trim71 G T 9: 114,525,047 H296Q probably damaging Het
Vmn1r67 A T 7: 10,446,913 I35L probably benign Het
Vnn3 A G 10: 23,851,722 T47A probably benign Het
Zscan10 A T 17: 23,605,607 Q12H probably damaging Het
Other mutations in Ighg2c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02087:Ighg2c APN 12 113285366 unclassified probably benign
IGL02560:Ighg2c APN 12 113287884 missense unknown
IGL03339:Ighg2c APN 12 113287994 missense unknown
R0047:Ighg2c UTSW 12 113288168 splice site probably benign
R0047:Ighg2c UTSW 12 113288168 splice site probably benign
R0415:Ighg2c UTSW 12 113287910 missense unknown
R0571:Ighg2c UTSW 12 113288762 nonsense probably null
R0634:Ighg2c UTSW 12 113287964 missense unknown
R0893:Ighg2c UTSW 12 113287433 missense unknown
R1169:Ighg2c UTSW 12 113285952 unclassified probably benign
R3895:Ighg2c UTSW 12 113287658 missense unknown
R5065:Ighg2c UTSW 12 113288088 missense unknown
R6407:Ighg2c UTSW 12 113288651 missense unknown
R7052:Ighg2c UTSW 12 113288723 missense
R7231:Ighg2c UTSW 12 113288016 missense
R7513:Ighg2c UTSW 12 113288851 missense
Z1177:Ighg2c UTSW 12 113287680 missense
Predicted Primers
Posted On2018-09-12