Incidental Mutation 'R6851:Or9m1b'
ID 534959
Institutional Source Beutler Lab
Gene Symbol Or9m1b
Ensembl Gene ENSMUSG00000075141
Gene Name olfactory receptor family 9 subfamily M member 1B
Synonyms Olfr1160, MOR173-1, GA_x6K02T2Q125-49498697-49497765
MMRRC Submission 044955-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R6851 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87836161-87837120 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87836300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 265 (H265L)
Ref Sequence ENSEMBL: ENSMUSP00000148857 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099839] [ENSMUST00000215457]
AlphaFold A2AVT0
Predicted Effect probably damaging
Transcript: ENSMUST00000099839
AA Change: H274L

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000097427
Gene: ENSMUSG00000075141
AA Change: H274L

DomainStartEndE-ValueType
Pfam:7tm_4 40 316 1.2e-46 PFAM
Pfam:7tm_1 50 298 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215457
AA Change: H265L

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A T 17: 46,623,345 (GRCm39) C856S probably benign Het
Arrdc2 T C 8: 71,291,369 (GRCm39) E153G probably damaging Het
Cacna1d T C 14: 29,764,739 (GRCm39) D2033G probably damaging Het
Cacna1s G A 1: 136,020,432 (GRCm39) R823Q probably benign Het
Cracr2a A T 6: 127,585,679 (GRCm39) D159V probably damaging Het
Defa35 T C 8: 21,555,146 (GRCm39) I22T possibly damaging Het
Dgke T C 11: 88,943,309 (GRCm39) T227A probably benign Het
Efcab3 G A 11: 104,896,521 (GRCm39) R4290K probably benign Het
Firrm G A 1: 163,792,336 (GRCm39) R554C probably damaging Het
Galnt10 G A 11: 57,656,458 (GRCm39) R214Q probably damaging Het
Gpr180 T C 14: 118,391,037 (GRCm39) Y189H probably damaging Het
Hadh A G 3: 131,065,620 (GRCm39) S13P possibly damaging Het
Hcn2 T A 10: 79,564,947 (GRCm39) probably null Het
Irgm2 T C 11: 58,110,641 (GRCm39) S123P possibly damaging Het
Kcnv1 T A 15: 44,972,594 (GRCm39) I430F probably damaging Het
Kif13b G A 14: 65,010,514 (GRCm39) C1271Y probably damaging Het
Klhdc3 A T 17: 46,989,218 (GRCm39) I48N possibly damaging Het
Lama5 G A 2: 179,833,455 (GRCm39) P1519L probably damaging Het
Mprip T A 11: 59,649,841 (GRCm39) W1182R probably damaging Het
Mycbp2 A T 14: 103,497,630 (GRCm39) probably null Het
Or12e1 T A 2: 87,022,813 (GRCm39) S261T probably benign Het
Or1j11 T A 2: 36,311,832 (GRCm39) C141S probably damaging Het
Or8b51 A G 9: 38,569,481 (GRCm39) V69A probably benign Het
Or8h9 T C 2: 86,789,611 (GRCm39) T64A possibly damaging Het
Osbpl8 T A 10: 111,106,479 (GRCm39) Y295* probably null Het
Pex5 A G 6: 124,380,113 (GRCm39) S275P possibly damaging Het
Prrc2c TTGCTGCTGCTGCTGCTGCTGCTGCTGC TTGCTGCTGCTGCTGCTGCTGCTGC 1: 162,536,630 (GRCm39) probably benign Het
Sele G T 1: 163,881,521 (GRCm39) G543C probably damaging Het
Serpina3k A C 12: 104,311,625 (GRCm39) Y401S probably benign Het
Slc13a4 A G 6: 35,278,668 (GRCm39) S74P probably damaging Het
Spata31d1a A G 13: 59,851,725 (GRCm39) L114P unknown Het
Syne1 G T 10: 5,212,703 (GRCm39) C3295* probably null Het
Tepsin G T 11: 119,987,787 (GRCm39) H44N probably damaging Het
Tpp1 A T 7: 105,398,919 (GRCm39) V170E probably damaging Het
Trav3-1 T C 14: 52,818,428 (GRCm39) V34A probably damaging Het
Tsbp1 A T 17: 34,679,146 (GRCm39) Y303F possibly damaging Het
Ush2a T C 1: 188,265,402 (GRCm39) V1642A probably benign Het
Vmn1r122 A G 7: 20,867,845 (GRCm39) I70T probably benign Het
Vmn2r96 A G 17: 18,802,800 (GRCm39) M237V possibly damaging Het
Wdr75 A G 1: 45,862,587 (GRCm39) E802G probably benign Het
Zan G A 5: 137,394,453 (GRCm39) T4462I unknown Het
Other mutations in Or9m1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Or9m1b APN 2 87,836,988 (GRCm39) missense probably damaging 1.00
IGL01321:Or9m1b APN 2 87,836,589 (GRCm39) missense probably damaging 0.97
IGL02009:Or9m1b APN 2 87,837,117 (GRCm39) missense probably benign
IGL03409:Or9m1b APN 2 87,836,239 (GRCm39) missense probably damaging 1.00
R0089:Or9m1b UTSW 2 87,836,331 (GRCm39) missense probably damaging 1.00
R0685:Or9m1b UTSW 2 87,836,762 (GRCm39) missense probably damaging 1.00
R1416:Or9m1b UTSW 2 87,836,915 (GRCm39) missense probably damaging 1.00
R1852:Or9m1b UTSW 2 87,836,865 (GRCm39) missense probably damaging 1.00
R1965:Or9m1b UTSW 2 87,836,648 (GRCm39) missense probably damaging 1.00
R2206:Or9m1b UTSW 2 87,836,579 (GRCm39) missense probably benign 0.00
R4853:Or9m1b UTSW 2 87,836,448 (GRCm39) missense probably damaging 1.00
R5599:Or9m1b UTSW 2 87,836,349 (GRCm39) missense probably benign 0.44
R6995:Or9m1b UTSW 2 87,836,529 (GRCm39) missense probably benign 0.00
R7817:Or9m1b UTSW 2 87,836,355 (GRCm39) missense probably benign
R7970:Or9m1b UTSW 2 87,836,169 (GRCm39) missense probably benign 0.02
R7984:Or9m1b UTSW 2 87,836,969 (GRCm39) missense probably damaging 1.00
R8325:Or9m1b UTSW 2 87,836,537 (GRCm39) missense probably damaging 1.00
R8912:Or9m1b UTSW 2 87,836,661 (GRCm39) missense possibly damaging 0.93
Z1176:Or9m1b UTSW 2 87,836,781 (GRCm39) missense probably damaging 0.98
Z31818:Or9m1b UTSW 2 87,836,234 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTAATGCTGTAAAGCCCATCG -3'
(R):5'- CTGCTTTGATACCTACACACATGAC -3'

Sequencing Primer
(F):5'- GCTGTAAAGCCCATCGTTAAATAGC -3'
(R):5'- CAAGTTTGGTGGAAGCTCTCTCTC -3'
Posted On 2018-09-12