Incidental Mutation 'R6857:Or5w17'
ID 535298
Institutional Source Beutler Lab
Gene Symbol Or5w17
Ensembl Gene ENSMUSG00000075148
Gene Name olfactory receptor family 5 subfamily W member 17, pseudogene 1
Synonyms Olfr1141, GA_x6K02T2Q125-49257818-49256883, MOR177-10
MMRRC Submission 044959-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R6857 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87583400-87584335 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87583831 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 169 (C169S)
Ref Sequence ENSEMBL: ENSMUSP00000097433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099846]
AlphaFold Q8VFQ7
Predicted Effect probably damaging
Transcript: ENSMUST00000099846
AA Change: C169S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097433
Gene: ENSMUSG00000075148
AA Change: C169S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.8e-28 PFAM
Pfam:7tm_1 41 290 1.5e-6 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A G 11: 110,110,514 (GRCm39) L545P possibly damaging Het
Adam4 T C 12: 81,466,723 (GRCm39) T633A possibly damaging Het
Ahnak C T 19: 9,014,532 (GRCm39) Q119* probably null Het
Anxa10 C A 8: 62,514,051 (GRCm39) A239S probably benign Het
B020011L13Rik A T 1: 117,729,018 (GRCm39) H175L probably benign Het
Best2 A G 8: 85,734,452 (GRCm39) V422A probably benign Het
Cc2d2b T C 19: 40,759,309 (GRCm39) F298S possibly damaging Het
Cd38 T A 5: 44,063,540 (GRCm39) M211K probably damaging Het
Cd3d T G 9: 44,896,902 (GRCm39) M92R probably damaging Het
Cdk5rap2 C A 4: 70,163,633 (GRCm39) E1474* probably null Het
Clvs1 A G 4: 9,449,433 (GRCm39) K341E probably benign Het
Copg2 G T 6: 30,840,533 (GRCm39) D112E possibly damaging Het
Cspg4b A T 13: 113,456,492 (GRCm39) N846I probably damaging Het
Dmxl1 A T 18: 49,997,902 (GRCm39) N697Y probably damaging Het
Dync1h1 T C 12: 110,624,981 (GRCm39) S3803P possibly damaging Het
Ecpas T A 4: 58,814,065 (GRCm39) D1347V probably damaging Het
Epx T A 11: 87,760,781 (GRCm39) K384* probably null Het
Fam135a G C 1: 24,053,870 (GRCm39) D1222E probably damaging Het
Fndc1 T A 17: 7,991,002 (GRCm39) H898L unknown Het
Gapvd1 A G 2: 34,618,389 (GRCm39) I190T probably damaging Het
Hax1 T G 3: 89,904,759 (GRCm39) S122R probably damaging Het
Hdac9 T G 12: 34,443,362 (GRCm39) M272L probably benign Het
Itgb7 T C 15: 102,131,900 (GRCm39) S228G probably damaging Het
Itpr2 C A 6: 146,298,517 (GRCm39) E315* probably null Het
Kctd8 T C 5: 69,454,045 (GRCm39) N331D probably benign Het
Ky G A 9: 102,419,631 (GRCm39) G546E probably damaging Het
Lao1 T C 4: 118,821,023 (GRCm39) probably null Het
Mtmr12 T A 15: 12,263,918 (GRCm39) W427R probably damaging Het
Mxra8 A G 4: 155,927,593 (GRCm39) K434E possibly damaging Het
Myh4 T C 11: 67,140,711 (GRCm39) C676R possibly damaging Het
Nek7 C T 1: 138,443,420 (GRCm39) G178R probably damaging Het
Or8b50 T C 9: 38,518,307 (GRCm39) L182P probably benign Het
Or8k35 A T 2: 86,424,608 (GRCm39) L188H probably damaging Het
Paqr5 G T 9: 61,883,370 (GRCm39) H41N probably damaging Het
Plekha8 T C 6: 54,606,920 (GRCm39) L405P probably damaging Het
Plpbp A G 8: 27,535,454 (GRCm39) N79S possibly damaging Het
Plxnd1 G T 6: 115,970,724 (GRCm39) A348E probably benign Het
Prdm9 T C 17: 15,764,518 (GRCm39) Q754R probably benign Het
Pygm G T 19: 6,443,787 (GRCm39) G583C probably damaging Het
Rgs12 A T 5: 35,187,366 (GRCm39) K213* probably null Het
Serpina3m T C 12: 104,355,585 (GRCm39) L84P probably damaging Het
Tab2 T C 10: 7,796,177 (GRCm39) T102A possibly damaging Het
Tagln3 G T 16: 45,544,599 (GRCm39) A24E probably benign Het
Tanc2 A G 11: 105,801,114 (GRCm39) E1110G possibly damaging Het
Tcf3 T C 10: 80,252,733 (GRCm39) probably null Het
Tmem14a T C 1: 21,299,769 (GRCm39) probably benign Het
Ttn T A 2: 76,748,275 (GRCm39) E4258V possibly damaging Het
Ubr4 G A 4: 139,213,362 (GRCm39) D5104N possibly damaging Het
Ugt2b37 C G 5: 87,388,705 (GRCm39) A503P probably damaging Het
Unc45b A G 11: 82,804,038 (GRCm39) I72V probably benign Het
Vmn1r88 A T 7: 12,912,258 (GRCm39) M205L possibly damaging Het
Vmn2r109 C T 17: 20,760,932 (GRCm39) M808I probably benign Het
Wdr72 G T 9: 74,062,323 (GRCm39) V490L probably damaging Het
Zfp1004 G T 2: 150,033,982 (GRCm39) C132F probably damaging Het
Zfp998 A T 13: 66,580,161 (GRCm39) H107Q probably benign Het
Zgrf1 T A 3: 127,375,096 (GRCm39) V785E probably damaging Het
Zswim7 A T 11: 62,171,955 (GRCm39) probably benign Het
Other mutations in Or5w17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01143:Or5w17 APN 2 87,584,278 (GRCm39) missense probably benign 0.00
IGL01412:Or5w17 APN 2 87,583,461 (GRCm39) missense probably damaging 1.00
IGL01533:Or5w17 APN 2 87,583,412 (GRCm39) missense probably benign 0.01
IGL02455:Or5w17 APN 2 87,583,927 (GRCm39) missense possibly damaging 0.95
IGL02698:Or5w17 APN 2 87,584,188 (GRCm39) nonsense probably null
PIT4480001:Or5w17 UTSW 2 87,584,127 (GRCm39) missense possibly damaging 0.95
R0543:Or5w17 UTSW 2 87,583,994 (GRCm39) missense probably damaging 1.00
R1542:Or5w17 UTSW 2 87,583,662 (GRCm39) missense probably damaging 0.99
R1750:Or5w17 UTSW 2 87,583,530 (GRCm39) missense probably damaging 0.97
R1844:Or5w17 UTSW 2 87,584,334 (GRCm39) start codon destroyed probably null 1.00
R2248:Or5w17 UTSW 2 87,584,287 (GRCm39) missense probably null 0.05
R4064:Or5w17 UTSW 2 87,584,133 (GRCm39) missense probably damaging 1.00
R5193:Or5w17 UTSW 2 87,583,448 (GRCm39) missense possibly damaging 0.59
R5861:Or5w17 UTSW 2 87,583,922 (GRCm39) missense probably benign 0.01
R6146:Or5w17 UTSW 2 87,583,602 (GRCm39) missense probably damaging 1.00
R6197:Or5w17 UTSW 2 87,583,696 (GRCm39) missense probably benign 0.15
R6481:Or5w17 UTSW 2 87,583,812 (GRCm39) missense probably damaging 1.00
R6904:Or5w17 UTSW 2 87,584,223 (GRCm39) missense probably benign 0.00
R6962:Or5w17 UTSW 2 87,584,071 (GRCm39) missense probably benign
R7014:Or5w17 UTSW 2 87,584,215 (GRCm39) missense probably benign 0.00
R8229:Or5w17 UTSW 2 87,583,408 (GRCm39) missense probably benign 0.00
R8723:Or5w17 UTSW 2 87,583,501 (GRCm39) missense possibly damaging 0.69
R8883:Or5w17 UTSW 2 87,583,838 (GRCm39) missense probably damaging 1.00
R9129:Or5w17 UTSW 2 87,584,048 (GRCm39) missense probably benign 0.00
R9587:Or5w17 UTSW 2 87,584,184 (GRCm39) missense possibly damaging 0.79
R9665:Or5w17 UTSW 2 87,583,671 (GRCm39) missense probably damaging 0.97
T0722:Or5w17 UTSW 2 87,583,467 (GRCm39) missense probably damaging 1.00
Z1177:Or5w17 UTSW 2 87,583,534 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- AATTGCAACAGCAGTCAGATGC -3'
(R):5'- TGTGTTGCCAGCAGTAATGG -3'

Sequencing Primer
(F):5'- TAAACCTTCCCTTGGCAGAATGG -3'
(R):5'- CCAGCAGTAATGGCCTTTGATCAG -3'
Posted On 2018-09-12