Mutagenetix > Incidental Mutation

Incidental Mutation 'R6858:Vmn2r79'

535372

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r79

Ensembl Gene

ENSMUSG00000090362

Gene Name

vomeronasal 2, receptor 79

Synonyms

EG621430

MMRRC Submission

044960-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R6858 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

86645673-86687176 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 86686580 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 654 (M654L)

Ref Sequence

ENSEMBL: ENSMUSP00000132478 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164462]

AlphaFold

E9Q067

Predicted Effect

probably benign
Transcript: ENSMUST00000164462
AA Change: M654L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: M654L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	1.9e-31	PFAM
Pfam:NCD3G	506	559	3.1e-21	PFAM
Pfam:7tm_3	592	827	2.8e-53	PFAM

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

96% (49/51)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldob	T	C	4: 49,538,796 (GRCm39)	T241A	probably benign	Het
Arid4a	A	G	12: 71,070,283 (GRCm39)	I65V	probably benign	Het
Bhmt2	C	T	13: 93,807,948 (GRCm39)	E47K	probably damaging	Het
Bpifa3	G	A	2: 153,979,514 (GRCm39)	G213D	probably benign	Het
C4b	C	G	17: 34,948,805 (GRCm39)	A1548P	probably damaging	Het
Ccdc39	A	G	3: 33,874,017 (GRCm39)	V605A	probably damaging	Het
Cept1	A	T	3: 106,420,195 (GRCm39)		probably null	Het
Cntrl	T	C	2: 35,052,107 (GRCm39)		probably null	Het
Col3a1	A	G	1: 45,385,144 (GRCm39)	D87G	probably damaging	Het
Crim1	A	T	17: 78,623,056 (GRCm39)	E418V	probably damaging	Het
Crtac1	T	C	19: 42,307,174 (GRCm39)	I196M	possibly damaging	Het
Crtap	T	C	9: 114,209,084 (GRCm39)	Y320C	probably damaging	Het
Cttnbp2	A	G	6: 18,448,452 (GRCm39)	V27A	probably damaging	Het
Cyp2c69	G	A	19: 39,866,009 (GRCm39)	L195F	probably benign	Het
Cyp2d26	G	A	15: 82,678,284 (GRCm39)	R31C	probably damaging	Het
Fan1	T	A	7: 64,022,234 (GRCm39)	N340Y	probably damaging	Het
Fign	G	T	2: 63,810,157 (GRCm39)	T371K	probably benign	Het
Fryl	T	C	5: 73,222,375 (GRCm39)	T2069A	probably damaging	Het
Gm3486	A	G	14: 41,210,322 (GRCm39)	I53T	probably damaging	Het
Gprc5d	T	C	6: 135,093,313 (GRCm39)	N198S	possibly damaging	Het
Ighv1-42	A	G	12: 114,900,966 (GRCm39)	S40P	probably damaging	Het
Itga8	A	G	2: 12,204,892 (GRCm39)	V515A	probably benign	Het
Kidins220	A	T	12: 25,058,542 (GRCm39)	I523L	possibly damaging	Het
Lmx1a	A	T	1: 167,660,450 (GRCm39)	N245I	probably damaging	Het
Med22	T	C	2: 26,795,949 (GRCm39)	D157G	possibly damaging	Het
Ola1	T	C	2: 72,927,574 (GRCm39)	H335R	probably damaging	Het
Or1a1	A	T	11: 74,086,925 (GRCm39)	M199L	probably benign	Het
Or4c12	A	G	2: 89,774,087 (GRCm39)	I124T	probably damaging	Het
Or6c213	A	G	10: 129,574,333 (GRCm39)	F151S	probably damaging	Het
Or7e166	T	C	9: 19,624,765 (GRCm39)	I214T	probably damaging	Het
Or8h9	A	G	2: 86,789,034 (GRCm39)	I256T	probably benign	Het
Pde1a	T	A	2: 79,959,502 (GRCm39)		probably benign	Het
Pdgfrb	G	A	18: 61,198,219 (GRCm39)	G304D	probably benign	Het
Potegl	T	C	2: 23,102,676 (GRCm39)	V138A	possibly damaging	Het
Prune2	T	A	19: 17,095,470 (GRCm39)	C325S	possibly damaging	Het
Ptk2b	T	C	14: 66,450,847 (GRCm39)	I40V	probably damaging	Het
Qrich1	A	G	9: 108,411,333 (GRCm39)	D286G	probably damaging	Het
Scn5a	T	C	9: 119,321,156 (GRCm39)	I1469V	probably benign	Het
Serpina3k	G	A	12: 104,311,504 (GRCm39)	A361T	possibly damaging	Het
Slc25a23	A	G	17: 57,365,171 (GRCm39)	Y73H	probably damaging	Het
Tmco3	A	G	8: 13,363,924 (GRCm39)	D82G	probably damaging	Het
Trbv28	G	T	6: 41,248,624 (GRCm39)	M51I	probably damaging	Het
Unc13b	A	T	4: 43,165,828 (GRCm39)	H204L	possibly damaging	Het
Vamp5	G	A	6: 72,357,424 (GRCm39)		probably benign	Het
Vmn1r25	T	C	6: 57,955,996 (GRCm39)	S98G	probably benign	Het
Vmn2r2	A	G	3: 64,044,915 (GRCm39)	F77S	probably damaging	Het
Zfp985	A	T	4: 147,667,764 (GRCm39)	K211*	probably null	Het
Zwilch	C	T	9: 64,060,869 (GRCm39)	D328N	probably damaging	Het

Other mutations in Vmn2r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01401:Vmn2r79	APN	7	86,686,481 (GRCm39)	missense	probably benign	0.01
IGL01675:Vmn2r79	APN	7	86,645,856 (GRCm39)	missense	probably benign	0.01
IGL01760:Vmn2r79	APN	7	86,651,366 (GRCm39)	missense	probably benign
IGL01834:Vmn2r79	APN	7	86,686,354 (GRCm39)	missense	probably benign	0.01
IGL01843:Vmn2r79	APN	7	86,686,485 (GRCm39)	missense	probably damaging	1.00
IGL01914:Vmn2r79	APN	7	86,686,571 (GRCm39)	missense	probably benign	0.14
IGL01980:Vmn2r79	APN	7	86,686,290 (GRCm39)	missense	possibly damaging	0.49
IGL02438:Vmn2r79	APN	7	86,651,744 (GRCm39)	missense	probably damaging	0.98
IGL02740:Vmn2r79	APN	7	86,653,366 (GRCm39)	missense	probably benign	0.00
IGL03052:Vmn2r79	UTSW	7	86,652,799 (GRCm39)	missense	probably benign	0.00
PIT4445001:Vmn2r79	UTSW	7	86,651,408 (GRCm39)	missense	possibly damaging	0.46
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0270:Vmn2r79	UTSW	7	86,652,594 (GRCm39)	missense	probably benign	0.00
R0336:Vmn2r79	UTSW	7	86,651,287 (GRCm39)	missense	probably benign	0.15
R0418:Vmn2r79	UTSW	7	86,651,611 (GRCm39)	missense	probably benign	0.18
R1070:Vmn2r79	UTSW	7	86,652,681 (GRCm39)	missense	probably damaging	1.00
R1234:Vmn2r79	UTSW	7	86,653,307 (GRCm39)	missense	possibly damaging	0.71
R1459:Vmn2r79	UTSW	7	86,687,002 (GRCm39)	missense	probably benign	0.01
R1513:Vmn2r79	UTSW	7	86,686,652 (GRCm39)	missense	probably benign	0.01
R1624:Vmn2r79	UTSW	7	86,653,247 (GRCm39)	critical splice acceptor site	probably null
R1633:Vmn2r79	UTSW	7	86,687,042 (GRCm39)	missense	possibly damaging	0.52
R1676:Vmn2r79	UTSW	7	86,651,839 (GRCm39)	missense	probably benign
R1781:Vmn2r79	UTSW	7	86,651,555 (GRCm39)	missense	probably benign	0.00
R1794:Vmn2r79	UTSW	7	86,650,621 (GRCm39)	missense	probably benign	0.37
R1823:Vmn2r79	UTSW	7	86,687,080 (GRCm39)	missense	probably damaging	1.00
R2013:Vmn2r79	UTSW	7	86,653,289 (GRCm39)	missense	possibly damaging	0.50
R2018:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2019:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2177:Vmn2r79	UTSW	7	86,645,839 (GRCm39)	missense	possibly damaging	0.94
R2984:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R3719:Vmn2r79	UTSW	7	86,651,245 (GRCm39)	missense	probably benign	0.05
R3798:Vmn2r79	UTSW	7	86,651,402 (GRCm39)	missense	possibly damaging	0.88
R3969:Vmn2r79	UTSW	7	86,652,801 (GRCm39)	missense	probably damaging	1.00
R4182:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4183:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4245:Vmn2r79	UTSW	7	86,651,624 (GRCm39)	missense	possibly damaging	0.73
R4301:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4391:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4393:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4394:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4396:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4397:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4592:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R4697:Vmn2r79	UTSW	7	86,687,168 (GRCm39)	missense	probably damaging	0.98
R4897:Vmn2r79	UTSW	7	86,650,675 (GRCm39)	missense	probably benign
R5016:Vmn2r79	UTSW	7	86,686,548 (GRCm39)	missense	probably benign	0.00
R5058:Vmn2r79	UTSW	7	86,651,423 (GRCm39)	missense	probably damaging	0.98
R5177:Vmn2r79	UTSW	7	86,651,177 (GRCm39)	missense	probably damaging	0.97
R6078:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6079:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6138:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6257:Vmn2r79	UTSW	7	86,651,778 (GRCm39)	missense	probably benign	0.27
R6260:Vmn2r79	UTSW	7	86,686,365 (GRCm39)	missense	probably benign	0.00
R6307:Vmn2r79	UTSW	7	86,686,976 (GRCm39)	missense	probably damaging	1.00
R6323:Vmn2r79	UTSW	7	86,650,522 (GRCm39)	missense	probably benign	0.05
R6374:Vmn2r79	UTSW	7	86,651,498 (GRCm39)	missense	probably benign	0.02
R6530:Vmn2r79	UTSW	7	86,651,252 (GRCm39)	missense	possibly damaging	0.91
R6546:Vmn2r79	UTSW	7	86,652,741 (GRCm39)	missense	probably benign	0.01
R6682:Vmn2r79	UTSW	7	86,653,370 (GRCm39)	missense	possibly damaging	0.69
R6965:Vmn2r79	UTSW	7	86,651,100 (GRCm39)	missense	probably benign	0.10
R7130:Vmn2r79	UTSW	7	86,651,474 (GRCm39)	missense	probably damaging	0.99
R7156:Vmn2r79	UTSW	7	86,686,851 (GRCm39)	missense	probably damaging	0.98
R7604:Vmn2r79	UTSW	7	86,652,592 (GRCm39)	critical splice acceptor site	probably null
R7691:Vmn2r79	UTSW	7	86,687,111 (GRCm39)	missense	probably damaging	0.96
R8055:Vmn2r79	UTSW	7	86,686,541 (GRCm39)	missense	possibly damaging	0.94
R8070:Vmn2r79	UTSW	7	86,651,336 (GRCm39)	missense	probably benign
R8073:Vmn2r79	UTSW	7	86,651,462 (GRCm39)	missense	probably benign	0.00
R8145:Vmn2r79	UTSW	7	86,686,862 (GRCm39)	missense	probably benign	0.02
R8263:Vmn2r79	UTSW	7	86,686,726 (GRCm39)	missense	possibly damaging	0.89
R8350:Vmn2r79	UTSW	7	86,686,741 (GRCm39)	nonsense	probably null
R8400:Vmn2r79	UTSW	7	86,651,308 (GRCm39)	missense	probably benign	0.00
R8814:Vmn2r79	UTSW	7	86,651,714 (GRCm39)	missense	probably benign	0.00
R8862:Vmn2r79	UTSW	7	86,645,712 (GRCm39)	missense	probably benign	0.23
R9146:Vmn2r79	UTSW	7	86,650,681 (GRCm39)	nonsense	probably null
R9276:Vmn2r79	UTSW	7	86,687,045 (GRCm39)	missense	probably damaging	1.00
R9361:Vmn2r79	UTSW	7	86,652,822 (GRCm39)	critical splice donor site	probably null
R9676:Vmn2r79	UTSW	7	86,686,452 (GRCm39)	missense	probably damaging	1.00
U15987:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
X0054:Vmn2r79	UTSW	7	86,653,270 (GRCm39)	missense	probably benign	0.01
Z1088:Vmn2r79	UTSW	7	86,651,549 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r79	UTSW	7	86,686,377 (GRCm39)	missense	probably benign
Z1176:Vmn2r79	UTSW	7	86,651,526 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AAGAACCCTTGGGAATGGCTC -3'
(R):5'- CAGATTCCACAGAGCATCATTTG -3'

Sequencing Primer
(F):5'- CCCTTGGGAATGGCTCTGACTG -3'
(R):5'- CCACAGAGCATCATTTGTATTGTGG -3'

Posted On

2018-09-12