Incidental Mutation 'R6850:Or4c102'
ID 535578
Institutional Source Beutler Lab
Gene Symbol Or4c102
Ensembl Gene ENSMUSG00000068808
Gene Name olfactory receptor family 4 subfamily C member 102
Synonyms GA_x6K02T2Q125-50079044-50079964, Olfr1189, MOR237-2
MMRRC Submission 044954-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R6850 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88422150-88423070 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 88422650 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 167 (C167*)
Ref Sequence ENSEMBL: ENSMUSP00000149696 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090700] [ENSMUST00000213679]
AlphaFold A2AV11
Predicted Effect probably null
Transcript: ENSMUST00000090700
AA Change: C167*
SMART Domains Protein: ENSMUSP00000088201
Gene: ENSMUSG00000068808
AA Change: C167*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 9.6e-42 PFAM
Pfam:7tm_1 39 285 4.4e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213679
AA Change: C167*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb T C 10: 10,270,318 (GRCm39) M927V probably benign Het
Agr2 A G 12: 36,045,558 (GRCm39) I15V probably benign Het
Alpk1 A G 3: 127,523,012 (GRCm39) I10T possibly damaging Het
Art5 A G 7: 101,747,302 (GRCm39) V159A possibly damaging Het
Asz1 G A 6: 18,108,942 (GRCm39) R32W probably benign Het
Atp8b1 A C 18: 64,689,923 (GRCm39) M603R possibly damaging Het
Cacna1s G A 1: 136,020,432 (GRCm39) R823Q probably benign Het
Car9 A G 4: 43,507,321 (GRCm39) E3G probably damaging Het
Cpne3 A T 4: 19,535,231 (GRCm39) I267N possibly damaging Het
Cyp2c65 T A 19: 39,057,535 (GRCm39) F57I probably benign Het
D430041D05Rik T C 2: 104,031,604 (GRCm39) K980R probably damaging Het
Dnhd1 G T 7: 105,369,137 (GRCm39) G4303W possibly damaging Het
Dnmt3a A G 12: 3,947,600 (GRCm39) N485D probably benign Het
Dusp4 A T 8: 35,283,651 (GRCm39) K166* probably null Het
Ect2 T C 3: 27,193,034 (GRCm39) D344G probably damaging Het
Eif2b1 T C 5: 124,717,069 (GRCm39) D3G probably benign Het
Ermp1 A G 19: 29,594,041 (GRCm39) Y710H probably damaging Het
Gar1 T C 3: 129,623,038 (GRCm39) N117S probably damaging Het
H2-T10 A G 17: 36,430,152 (GRCm39) L263P probably damaging Het
Iqcn A T 8: 71,163,425 (GRCm39) N873Y probably damaging Het
Itga7 A T 10: 128,781,385 (GRCm39) I621F probably damaging Het
Kcna3 A T 3: 106,944,475 (GRCm39) D246V probably damaging Het
Kctd12 C T 14: 103,219,414 (GRCm39) G155S probably benign Het
Lrtm1 T C 14: 28,749,407 (GRCm39) V256A probably benign Het
Mcf2l T C 8: 13,059,476 (GRCm39) F629L possibly damaging Het
Mphosph9 A G 5: 124,399,019 (GRCm39) F999L probably damaging Het
Mtres1 ACTGCACCACCT ACT 10: 43,408,721 (GRCm39) probably benign Het
Obscn C T 11: 58,958,950 (GRCm39) V3643M possibly damaging Het
Obscn C T 11: 58,892,955 (GRCm39) A6764T possibly damaging Het
Or8g18 T C 9: 39,149,271 (GRCm39) I150V probably benign Het
Pdhx T C 2: 102,871,445 (GRCm39) H195R probably damaging Het
Pdilt A T 7: 119,086,182 (GRCm39) V511E probably damaging Het
Prima1 C T 12: 103,163,594 (GRCm39) D126N probably benign Het
Prrc2c TTGCTGCTGCTGCTGCTGCTGCTGCTGC TTGCTGCTGCTGCTGCTGCTGCTGC 1: 162,536,630 (GRCm39) probably benign Het
Prune2 C A 19: 17,099,552 (GRCm39) D1685E probably benign Het
Ptgs2 A T 1: 149,981,291 (GRCm39) I525F probably damaging Het
Rab11fip2 A T 19: 59,925,441 (GRCm39) F259I possibly damaging Het
Ranbp3l C A 15: 9,058,808 (GRCm39) D216E probably damaging Het
Scn5a A T 9: 119,330,815 (GRCm39) L1240Q possibly damaging Het
Sohlh2 A T 3: 55,099,707 (GRCm39) T160S probably benign Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Spata31h1 A C 10: 82,128,888 (GRCm39) M1374R possibly damaging Het
Tank A G 2: 61,480,346 (GRCm39) E294G probably benign Het
Tars1 T A 15: 11,392,885 (GRCm39) Y187F probably benign Het
Tas2r144 T A 6: 42,192,857 (GRCm39) M199K possibly damaging Het
Tdrd3 T C 14: 87,695,515 (GRCm39) probably benign Het
Tecta T A 9: 42,255,134 (GRCm39) D1683V probably benign Het
Tln2 A G 9: 67,165,817 (GRCm39) I2098T probably damaging Het
Tmie A G 9: 110,695,980 (GRCm39) I137T possibly damaging Het
Trim45 T A 3: 100,830,541 (GRCm39) L105* probably null Het
Trpv3 G A 11: 73,182,519 (GRCm39) G568S probably damaging Het
Wdr75 A G 1: 45,853,758 (GRCm39) T390A probably benign Het
Wdr97 A G 15: 76,241,996 (GRCm39) Y763C probably damaging Het
Zfp35 G A 18: 24,135,839 (GRCm39) R61H possibly damaging Het
Other mutations in Or4c102
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02306:Or4c102 APN 2 88,422,950 (GRCm39) missense probably benign 0.22
R0115:Or4c102 UTSW 2 88,422,999 (GRCm39) missense probably damaging 1.00
R0481:Or4c102 UTSW 2 88,422,999 (GRCm39) missense probably damaging 1.00
R0565:Or4c102 UTSW 2 88,422,353 (GRCm39) missense probably benign 0.39
R1106:Or4c102 UTSW 2 88,422,355 (GRCm39) missense probably benign 0.01
R1501:Or4c102 UTSW 2 88,422,492 (GRCm39) missense possibly damaging 0.94
R1616:Or4c102 UTSW 2 88,422,352 (GRCm39) missense probably damaging 0.99
R1763:Or4c102 UTSW 2 88,422,780 (GRCm39) missense probably benign 0.02
R1847:Or4c102 UTSW 2 88,422,516 (GRCm39) missense probably damaging 1.00
R1989:Or4c102 UTSW 2 88,422,943 (GRCm39) missense probably damaging 0.99
R3436:Or4c102 UTSW 2 88,422,448 (GRCm39) missense probably damaging 1.00
R3500:Or4c102 UTSW 2 88,422,285 (GRCm39) missense probably damaging 1.00
R4410:Or4c102 UTSW 2 88,422,765 (GRCm39) missense probably benign 0.03
R4463:Or4c102 UTSW 2 88,422,976 (GRCm39) missense possibly damaging 0.77
R5005:Or4c102 UTSW 2 88,422,348 (GRCm39) missense probably benign 0.00
R5174:Or4c102 UTSW 2 88,422,992 (GRCm39) missense probably damaging 1.00
R5557:Or4c102 UTSW 2 88,422,897 (GRCm39) missense probably damaging 1.00
R6354:Or4c102 UTSW 2 88,422,478 (GRCm39) missense probably damaging 1.00
R7522:Or4c102 UTSW 2 88,423,005 (GRCm39) missense possibly damaging 0.94
R7837:Or4c102 UTSW 2 88,422,723 (GRCm39) missense possibly damaging 0.80
R8252:Or4c102 UTSW 2 88,423,011 (GRCm39) missense probably damaging 1.00
R8345:Or4c102 UTSW 2 88,422,435 (GRCm39) missense probably benign 0.10
R9346:Or4c102 UTSW 2 88,423,062 (GRCm39) missense probably benign
R9425:Or4c102 UTSW 2 88,422,877 (GRCm39) missense probably damaging 0.99
R9632:Or4c102 UTSW 2 88,423,057 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TATGACCCAGCTATTTGCAGAAC -3'
(R):5'- TAGAGAGGGCTTTGCGTCTC -3'

Sequencing Primer
(F):5'- GACCCAGCTATTTGCAGAACATTTC -3'
(R):5'- GCGTCTCCCTTCAGAACTATAAG -3'
Posted On 2018-09-12