Mutagenetix > Incidental Mutation

Incidental Mutation 'R6430:Vmn1r3'

535641

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r3

Ensembl Gene

ENSMUSG00000115466

Gene Name

vomeronasal 1 receptor 3

Synonyms

Gm11778

MMRRC Submission

044568-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.309) question?

Stock #

R6430 (G1)

Quality Score

44.0073

Status

Validated

Chromosome

Chromosomal Location

3184385-3185305 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 3184971 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 112 (T112I)

Ref Sequence

ENSEMBL: ENSMUSP00000100790 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105159]

AlphaFold

A2AMT7

Predicted Effect

probably benign
Transcript: ENSMUST00000105159
AA Change: T112I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000100790
Gene: ENSMUSG00000115466
AA Change: T112I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	6	302	1.7e-9	PFAM
Pfam:7tm_1	30	292	5.1e-7	PFAM
Pfam:V1R	34	298	1.2e-35	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.7%

Validation Efficiency

100% (47/47)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AI661453	C	A	17: 47,777,722 (GRCm39)		probably benign	Het
Ank1	T	A	8: 23,622,125 (GRCm39)	L1513Q	probably damaging	Het
Ap2a1	C	A	7: 44,553,253 (GRCm39)	V676L	probably benign	Het
Arid2	T	C	15: 96,261,575 (GRCm39)	V477A	probably benign	Het
Auh	C	A	13: 53,083,446 (GRCm39)	G17C	probably benign	Het
B3gnt7	T	C	1: 86,233,839 (GRCm39)	F362L	possibly damaging	Het
Cd207	C	T	6: 83,652,869 (GRCm39)	R87H	probably benign	Het
Cdyl	A	G	13: 36,055,589 (GRCm39)	K503R	possibly damaging	Het
Cep350	A	G	1: 155,770,419 (GRCm39)	S1824P	probably damaging	Het
Cmas	T	A	6: 142,713,650 (GRCm39)	M225K	probably benign	Het
Dhx29	T	C	13: 113,081,153 (GRCm39)	S396P	possibly damaging	Het
Epg5	T	C	18: 78,019,100 (GRCm39)	S958P	probably damaging	Het
Espnl	T	C	1: 91,249,970 (GRCm39)	L39P	possibly damaging	Het
Fcsk	A	G	8: 111,610,748 (GRCm39)	V915A	probably benign	Het
Flacc1	T	A	1: 58,717,448 (GRCm39)	K154N	probably damaging	Het
Gatb	A	G	3: 85,544,345 (GRCm39)	N438D	probably benign	Het
Hspg2	T	C	4: 137,266,707 (GRCm39)	C1932R	probably damaging	Het
Jmjd1c	C	T	10: 67,059,939 (GRCm39)	T662I	possibly damaging	Het
Kcng4	A	G	8: 120,359,789 (GRCm39)	S196P	probably damaging	Het
Kcnh7	T	G	2: 62,680,876 (GRCm39)	H237P	probably benign	Het
Klhl38	T	C	15: 58,185,707 (GRCm39)	T341A	probably benign	Het
Klra9	G	T	6: 130,155,995 (GRCm39)	Y253*	probably null	Het
Man2c1	T	C	9: 57,038,517 (GRCm39)	V59A	possibly damaging	Het
Nr2c1	A	T	10: 94,031,203 (GRCm39)	H588L	possibly damaging	Het
Or14a259	A	T	7: 86,013,181 (GRCm39)	Y121*	probably null	Het
Or2j3	T	C	17: 38,616,249 (GRCm39)	I34M	probably benign	Het
Osbpl6	A	G	2: 76,409,620 (GRCm39)	E494G	probably damaging	Het
Per1	T	C	11: 68,995,122 (GRCm39)	L638S	probably damaging	Het
Plekhn1	T	C	4: 156,306,261 (GRCm39)	E603G	probably benign	Het
Prss12	A	T	3: 123,273,243 (GRCm39)	S280C	probably damaging	Het
Pudp	A	G	18: 50,701,307 (GRCm39)	I142T	probably benign	Het
Rabl6	A	T	2: 25,474,849 (GRCm39)	N620K	probably damaging	Het
Rttn	T	A	18: 89,039,809 (GRCm39)	C837S	probably null	Het
Slc16a7	A	G	10: 125,066,887 (GRCm39)	S251P	probably damaging	Het
Slc7a10	A	G	7: 34,897,083 (GRCm39)	I195V	probably benign	Het
Slc9a4	A	T	1: 40,640,014 (GRCm39)	R269*	probably null	Het
Slco6c1	T	A	1: 97,003,699 (GRCm39)	Q466L	probably benign	Het
Smc6	A	G	12: 11,359,235 (GRCm39)	N953S	probably benign	Het
Tex15	T	C	8: 34,061,329 (GRCm39)	V527A	probably benign	Het
Tln2	T	C	9: 67,179,947 (GRCm39)	Y808C	probably damaging	Het
Tmem145	T	C	7: 25,008,463 (GRCm39)	L289P	possibly damaging	Het
Trim3	A	G	7: 105,267,212 (GRCm39)	V389A	probably benign	Het
Vps11	C	A	9: 44,272,847 (GRCm39)	A28S	probably benign	Het
Zbtb41	T	A	1: 139,374,945 (GRCm39)	S802T	probably benign	Het
Zmynd10	A	T	9: 107,425,911 (GRCm39)	K82*	probably null	Het

Other mutations in Vmn1r3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03130:Vmn1r3	APN	4	3,185,214 (GRCm39)	missense	possibly damaging	0.89
PIT4131001:Vmn1r3	UTSW	4	3,184,774 (GRCm39)	missense	probably benign	0.02
PIT4131001:Vmn1r3	UTSW	4	3,184,691 (GRCm39)	missense	probably damaging	1.00
PIT4142001:Vmn1r3	UTSW	4	3,184,774 (GRCm39)	missense	probably benign	0.02
PIT4142001:Vmn1r3	UTSW	4	3,184,691 (GRCm39)	missense	probably damaging	1.00
R0972:Vmn1r3	UTSW	4	3,185,125 (GRCm39)	missense	probably damaging	1.00
R1423:Vmn1r3	UTSW	4	3,185,231 (GRCm39)	missense	probably damaging	1.00
R3902:Vmn1r3	UTSW	4	3,185,241 (GRCm39)	missense	probably benign	0.41
R4999:Vmn1r3	UTSW	4	3,185,009 (GRCm39)	nonsense	probably null
R6091:Vmn1r3	UTSW	4	3,184,684 (GRCm39)	missense	probably damaging	0.97
R6140:Vmn1r3	UTSW	4	3,185,031 (GRCm39)	missense	probably damaging	0.97
R6188:Vmn1r3	UTSW	4	3,185,017 (GRCm39)	missense	probably damaging	1.00
R6299:Vmn1r3	UTSW	4	3,185,098 (GRCm39)	missense	possibly damaging	0.95
R6303:Vmn1r3	UTSW	4	3,184,975 (GRCm39)	missense	probably damaging	1.00
R6304:Vmn1r3	UTSW	4	3,184,975 (GRCm39)	missense	probably damaging	1.00
R6317:Vmn1r3	UTSW	4	3,184,993 (GRCm39)	missense	probably benign	0.39
R6633:Vmn1r3	UTSW	4	3,184,971 (GRCm39)	missense	probably benign
R8919:Vmn1r3	UTSW	4	3,184,863 (GRCm39)	missense	probably benign	0.03
R9320:Vmn1r3	UTSW	4	3,185,284 (GRCm39)	missense	probably benign	0.00
R9357:Vmn1r3	UTSW	4	3,185,149 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn1r3	UTSW	4	3,185,304 (GRCm39)	start codon destroyed	probably null	0.60

Predicted Primers

PCR Primer
(F):5'- TGCTACACTGTCAGAAGCAAAC -3'
(R):5'- GCCCAAAGACCTGATTATAGAGC -3'

Sequencing Primer
(F):5'- CTGTCAGAAGCAAACAATGAGC -3'
(R):5'- GATTATAGAGCACTTGACTTTCGCC -3'

Posted On

2018-09-21