Incidental Mutation 'R6865:Olah'
ID 535846
Institutional Source Beutler Lab
Gene Symbol Olah
Ensembl Gene ENSMUSG00000026645
Gene Name oleoyl-ACP hydrolase
Synonyms Thedc1, E230009B14Rik
MMRRC Submission 045027-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6865 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 3343019-3367964 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 3343964 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 216 (D216G)
Ref Sequence ENSEMBL: ENSMUSP00000141485 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027955] [ENSMUST00000115087] [ENSMUST00000115089] [ENSMUST00000194918] [ENSMUST00000228935]
AlphaFold Q8R197
Predicted Effect possibly damaging
Transcript: ENSMUST00000027955
AA Change: D216G

PolyPhen 2 Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000027955
Gene: ENSMUSG00000026645
AA Change: D216G

DomainStartEndE-ValueType
Pfam:Thioesterase 27 257 1.7e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115087
AA Change: D216G

PolyPhen 2 Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000110739
Gene: ENSMUSG00000026645
AA Change: D216G

DomainStartEndE-ValueType
Pfam:Thioesterase 27 256 3.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115089
SMART Domains Protein: ENSMUSP00000110741
Gene: ENSMUSG00000026644

DomainStartEndE-ValueType
Pfam:ACBP 4 84 3.2e-30 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000194918
AA Change: D216G

PolyPhen 2 Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000141485
Gene: ENSMUSG00000026645
AA Change: D216G

DomainStartEndE-ValueType
Pfam:Thioesterase 27 256 3.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000228935
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c12 T A 13: 4,320,212 (GRCm39) M293L possibly damaging Het
Ankrd11 T C 8: 123,621,683 (GRCm39) D723G probably benign Het
Ankrd26 T C 6: 118,500,442 (GRCm39) R1010G possibly damaging Het
Apob G A 12: 8,058,847 (GRCm39) R2410H probably benign Het
Auh T C 13: 52,992,165 (GRCm39) D275G probably damaging Het
Card10 G T 15: 78,686,822 (GRCm39) D47E possibly damaging Het
Ccdc141 C T 2: 76,859,579 (GRCm39) probably null Het
Cfap206 T C 4: 34,714,448 (GRCm39) Y416C possibly damaging Het
Chuk A T 19: 44,075,354 (GRCm39) Y500* probably null Het
Cop1 T A 1: 159,136,524 (GRCm39) D536E probably damaging Het
Crh G C 3: 19,748,304 (GRCm39) P113A possibly damaging Het
Ddx54 T G 5: 120,759,892 (GRCm39) probably null Het
Efcab7 T C 4: 99,769,793 (GRCm39) S127P probably damaging Het
Efhc1 A G 1: 21,030,442 (GRCm39) Y125C probably damaging Het
Fga T A 3: 82,938,848 (GRCm39) C408S probably damaging Het
Flot2 T C 11: 77,940,318 (GRCm39) S22P probably benign Het
Fndc1 T A 17: 7,991,672 (GRCm39) T675S unknown Het
Foxc1 A G 13: 31,992,836 (GRCm39) D549G unknown Het
Gldc T C 19: 30,111,162 (GRCm39) N538S possibly damaging Het
Grk4 T G 5: 34,888,894 (GRCm39) V346G probably damaging Het
Gucy2c T C 6: 136,747,127 (GRCm39) R111G probably benign Het
Heatr6 C T 11: 83,659,966 (GRCm39) H504Y probably damaging Het
Lrp5 A T 19: 3,670,013 (GRCm39) probably null Het
Msrb1 T C 17: 24,955,685 (GRCm39) S2P possibly damaging Het
Muc5ac C T 7: 141,363,481 (GRCm39) probably benign Het
Myo3a A G 2: 22,464,313 (GRCm39) I185V probably benign Het
Myo5c T C 9: 75,176,878 (GRCm39) S608P probably benign Het
Nek6 A G 2: 38,459,678 (GRCm39) I174V probably benign Het
Nmt2 T C 2: 3,315,766 (GRCm39) V252A probably damaging Het
Nudt9 G T 5: 104,207,545 (GRCm39) R179M probably damaging Het
Nwd1 T C 8: 73,383,690 (GRCm39) V29A possibly damaging Het
Or13c7b T C 4: 43,821,346 (GRCm39) N5S probably benign Het
Or52n2 T C 7: 104,542,719 (GRCm39) I39V probably benign Het
Parp12 T C 6: 39,088,670 (GRCm39) I189V probably benign Het
Pkd1 T C 17: 24,795,461 (GRCm39) V2318A probably benign Het
Pknox1 T A 17: 31,807,534 (GRCm39) M51K probably damaging Het
Ppp1r12a C T 10: 108,098,242 (GRCm39) R321* probably null Het
Pxdn A G 12: 30,064,582 (GRCm39) probably null Het
Rab44 A T 17: 29,358,201 (GRCm39) I130F probably benign Het
Rnf130 T C 11: 49,962,091 (GRCm39) I179T probably damaging Het
Slc22a28 A T 19: 8,041,856 (GRCm39) C450* probably null Het
Slco1c1 A T 6: 141,485,778 (GRCm39) Y136F probably damaging Het
Synj2 C T 17: 6,067,844 (GRCm39) Q106* probably null Het
Uckl1 T C 2: 181,216,286 (GRCm39) N138S probably damaging Het
Usp19 G T 9: 108,376,018 (GRCm39) E203* probably null Het
Vdr A G 15: 97,755,386 (GRCm39) I379T probably damaging Het
Zfp503 C A 14: 22,036,101 (GRCm39) G272C probably damaging Het
Zfyve9 T C 4: 108,501,558 (GRCm39) N1218S possibly damaging Het
Zzz3 T A 3: 152,133,690 (GRCm39) D249E probably benign Het
Other mutations in Olah
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02527:Olah APN 2 3,343,979 (GRCm39) missense probably damaging 1.00
R0331:Olah UTSW 2 3,343,511 (GRCm39) missense probably damaging 1.00
R2153:Olah UTSW 2 3,366,306 (GRCm39) missense probably benign 0.19
R8460:Olah UTSW 2 3,362,762 (GRCm39) missense probably damaging 1.00
R9080:Olah UTSW 2 3,349,389 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GATCCTCATTGTGCAGGAGACC -3'
(R):5'- TTCTGATGGAGAGAGGCAGC -3'

Sequencing Primer
(F):5'- GCAGGAGACCAACATGTCTTTGTC -3'
(R):5'- TTCTTGTTAGGACTAGTGGAAGAAAG -3'
Posted On 2018-10-18