Incidental Mutation 'R6866:Fstl5'
ID 535904
Institutional Source Beutler Lab
Gene Symbol Fstl5
Ensembl Gene ENSMUSG00000034098
Gene Name follistatin-like 5
Synonyms 9130207J01Rik
MMRRC Submission 044965-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R6866 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 75981582-76617317 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 76229532 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 111 (H111L)
Ref Sequence ENSEMBL: ENSMUSP00000125393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038364] [ENSMUST00000160261]
AlphaFold Q8BFR2
Predicted Effect probably damaging
Transcript: ENSMUST00000038364
AA Change: H111L

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000038506
Gene: ENSMUSG00000034098
AA Change: H111L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000160261
AA Change: H111L

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125393
Gene: ENSMUSG00000034098
AA Change: H111L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alms1 A G 6: 85,598,080 (GRCm39) T1438A possibly damaging Het
Als2 T A 1: 59,250,292 (GRCm39) Q484L probably damaging Het
Apeh G A 9: 107,969,878 (GRCm39) H186Y probably damaging Het
Bcl2l13 T A 6: 120,839,850 (GRCm39) N49K probably benign Het
Bptf T C 11: 106,964,406 (GRCm39) D1596G probably damaging Het
Brsk1 T C 7: 4,709,406 (GRCm39) M325T probably damaging Het
Caly T C 7: 139,650,532 (GRCm39) M137V probably benign Het
Cdca2 T C 14: 67,931,115 (GRCm39) E526G possibly damaging Het
Cnga4 A G 7: 105,056,952 (GRCm39) S352G possibly damaging Het
Cntnap5c A C 17: 58,399,289 (GRCm39) T381P probably benign Het
Cr2 T A 1: 194,833,999 (GRCm39) Y633F probably damaging Het
Cryba1 T C 11: 77,610,355 (GRCm39) N120S probably benign Het
Cyfip2 G A 11: 46,133,286 (GRCm39) R805* probably null Het
Dnah7c C A 1: 46,696,403 (GRCm39) P2095Q probably damaging Het
Eif3k T C 7: 28,676,651 (GRCm39) E110G possibly damaging Het
Extl2 T A 3: 115,821,002 (GRCm39) M283K probably damaging Het
Extl2 A G 3: 115,821,001 (GRCm39) M283V probably damaging Het
Focad T C 4: 88,321,623 (GRCm39) I1658T probably benign Het
Garnl3 A G 2: 32,892,785 (GRCm39) probably null Het
Gm3633 T A 14: 42,462,579 (GRCm39) probably benign Het
Il4i1 T A 7: 44,485,963 (GRCm39) probably null Het
Kcnj6 A T 16: 94,563,536 (GRCm39) C321S probably damaging Het
Kif20a A T 18: 34,761,546 (GRCm39) Y313F probably benign Het
Kmt2d T G 15: 98,755,274 (GRCm39) probably benign Het
Kynu T A 2: 43,453,122 (GRCm39) Y48* probably null Het
Ly9 T C 1: 171,432,847 (GRCm39) I55M probably damaging Het
Mgme1 T C 2: 144,118,439 (GRCm39) V237A probably damaging Het
Mmp16 T A 4: 17,853,800 (GRCm39) L27H probably benign Het
Mtres1 ACTGCACCACCT ACT 10: 43,408,721 (GRCm39) probably benign Het
Myh1 A C 11: 67,115,219 (GRCm39) D1918A probably damaging Het
Myo5a G A 9: 75,047,970 (GRCm39) C266Y probably damaging Het
Nckap5l A G 15: 99,324,349 (GRCm39) I718T probably benign Het
Nptx1 A G 11: 119,437,476 (GRCm39) probably null Het
Or56a42-ps1 T A 7: 104,775,825 (GRCm39) M228L probably benign Het
Or5k16 A G 16: 58,736,351 (GRCm39) Y218H probably damaging Het
Or5p76 A G 7: 108,122,377 (GRCm39) F260S probably damaging Het
Phc3 T A 3: 30,968,680 (GRCm39) K783* probably null Het
Pkdrej A T 15: 85,705,082 (GRCm39) C285S probably damaging Het
Pot1b T A 17: 55,960,474 (GRCm39) T619S possibly damaging Het
Pramel32 T A 4: 88,545,977 (GRCm39) D455V probably damaging Het
Psg21 A T 7: 18,386,209 (GRCm39) V259E probably damaging Het
Pvr A C 7: 19,652,555 (GRCm39) I120S probably benign Het
Rbm17 T G 2: 11,602,901 (GRCm39) I68L probably benign Het
Rnf138 C T 18: 21,135,199 (GRCm39) P28L probably damaging Het
Rnf207 C T 4: 152,396,989 (GRCm39) C385Y possibly damaging Het
Serping1 A C 2: 84,600,577 (GRCm39) V255G probably benign Het
Slc25a3 A T 10: 90,955,567 (GRCm39) V91E probably damaging Het
Slc26a8 T C 17: 28,857,455 (GRCm39) D896G probably benign Het
Slc27a5 T A 7: 12,731,443 (GRCm39) T183S probably benign Het
Slc33a1 A T 3: 63,850,744 (GRCm39) F527I probably benign Het
Sting1 T C 18: 35,872,482 (GRCm39) H50R probably damaging Het
Strn4 A T 7: 16,562,710 (GRCm39) D283V probably damaging Het
Sult1e1 G A 5: 87,734,625 (GRCm39) T107I probably damaging Het
Tango6 G A 8: 107,469,104 (GRCm39) probably null Het
Tecrl G T 5: 83,461,161 (GRCm39) P99T probably damaging Het
Ticrr T C 7: 79,343,705 (GRCm39) L1190P possibly damaging Het
Timm50 C T 7: 28,005,370 (GRCm39) R349H probably damaging Het
Tjp2 A G 19: 24,079,355 (GRCm39) I840T probably damaging Het
Tmem45a2 T A 16: 56,867,386 (GRCm39) N105I probably damaging Het
Tsbp1 T A 17: 34,678,935 (GRCm39) C216S possibly damaging Het
Zfp148 T A 16: 33,288,496 (GRCm39) C162S probably damaging Het
Zfp534 T C 4: 147,758,938 (GRCm39) K577R probably benign Het
Other mutations in Fstl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01632:Fstl5 APN 3 76,615,135 (GRCm39) missense probably benign 0.30
IGL01658:Fstl5 APN 3 76,389,562 (GRCm39) missense possibly damaging 0.70
IGL01917:Fstl5 APN 3 76,615,153 (GRCm39) missense probably damaging 1.00
IGL02073:Fstl5 APN 3 76,566,959 (GRCm39) splice site probably benign
IGL02329:Fstl5 APN 3 76,496,302 (GRCm39) missense probably damaging 1.00
IGL02651:Fstl5 APN 3 76,500,841 (GRCm39) missense probably damaging 1.00
IGL02967:Fstl5 APN 3 76,229,498 (GRCm39) missense probably damaging 1.00
IGL03004:Fstl5 APN 3 76,555,738 (GRCm39) splice site probably benign
IGL03107:Fstl5 APN 3 76,443,618 (GRCm39) missense probably damaging 1.00
IGL03113:Fstl5 APN 3 76,337,099 (GRCm39) nonsense probably null
P0038:Fstl5 UTSW 3 76,052,369 (GRCm39) missense probably damaging 1.00
PIT4131001:Fstl5 UTSW 3 76,567,006 (GRCm39) missense probably damaging 0.99
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0078:Fstl5 UTSW 3 76,566,952 (GRCm39) splice site probably benign
R0137:Fstl5 UTSW 3 76,614,786 (GRCm39) missense probably damaging 1.00
R0183:Fstl5 UTSW 3 76,229,579 (GRCm39) missense possibly damaging 0.86
R0330:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R0427:Fstl5 UTSW 3 76,615,034 (GRCm39) nonsense probably null
R0687:Fstl5 UTSW 3 76,615,119 (GRCm39) missense possibly damaging 0.62
R1642:Fstl5 UTSW 3 76,317,929 (GRCm39) missense possibly damaging 0.80
R1765:Fstl5 UTSW 3 76,500,783 (GRCm39) missense possibly damaging 0.90
R1900:Fstl5 UTSW 3 76,615,467 (GRCm39) missense probably damaging 1.00
R1996:Fstl5 UTSW 3 76,615,141 (GRCm39) missense probably benign 0.19
R2157:Fstl5 UTSW 3 76,615,372 (GRCm39) missense possibly damaging 0.46
R2228:Fstl5 UTSW 3 76,389,659 (GRCm39) missense probably damaging 1.00
R2851:Fstl5 UTSW 3 76,337,045 (GRCm39) splice site probably benign
R4021:Fstl5 UTSW 3 76,536,282 (GRCm39) missense probably benign 0.00
R4086:Fstl5 UTSW 3 76,555,593 (GRCm39) missense probably damaging 1.00
R4777:Fstl5 UTSW 3 76,500,807 (GRCm39) missense probably damaging 1.00
R4829:Fstl5 UTSW 3 76,229,489 (GRCm39) missense probably damaging 1.00
R4934:Fstl5 UTSW 3 76,496,272 (GRCm39) missense probably damaging 1.00
R4955:Fstl5 UTSW 3 76,131,183 (GRCm39) critical splice donor site probably null
R4977:Fstl5 UTSW 3 76,317,801 (GRCm39) nonsense probably null
R5166:Fstl5 UTSW 3 76,536,267 (GRCm39) missense possibly damaging 0.86
R5232:Fstl5 UTSW 3 76,052,284 (GRCm39) missense possibly damaging 0.89
R5313:Fstl5 UTSW 3 76,500,812 (GRCm39) missense possibly damaging 0.90
R5584:Fstl5 UTSW 3 76,229,574 (GRCm39) missense probably damaging 1.00
R5647:Fstl5 UTSW 3 76,496,399 (GRCm39) missense probably damaging 1.00
R5842:Fstl5 UTSW 3 76,229,590 (GRCm39) missense possibly damaging 0.94
R5978:Fstl5 UTSW 3 76,052,392 (GRCm39) missense probably damaging 1.00
R6007:Fstl5 UTSW 3 76,317,899 (GRCm39) missense probably damaging 1.00
R6064:Fstl5 UTSW 3 76,229,605 (GRCm39) missense probably benign 0.13
R6327:Fstl5 UTSW 3 76,615,108 (GRCm39) missense probably benign 0.31
R6386:Fstl5 UTSW 3 76,229,373 (GRCm39) missense probably benign 0.13
R6523:Fstl5 UTSW 3 76,443,641 (GRCm39) missense probably benign 0.00
R6852:Fstl5 UTSW 3 76,615,162 (GRCm39) missense probably damaging 1.00
R6861:Fstl5 UTSW 3 76,229,523 (GRCm39) missense probably damaging 1.00
R7100:Fstl5 UTSW 3 76,443,600 (GRCm39) missense probably benign 0.11
R7341:Fstl5 UTSW 3 76,389,704 (GRCm39) splice site probably null
R7495:Fstl5 UTSW 3 76,615,099 (GRCm39) missense possibly damaging 0.85
R7558:Fstl5 UTSW 3 76,337,092 (GRCm39) missense possibly damaging 0.95
R7731:Fstl5 UTSW 3 76,569,069 (GRCm39) missense probably damaging 1.00
R7787:Fstl5 UTSW 3 76,337,131 (GRCm39) missense probably damaging 1.00
R7852:Fstl5 UTSW 3 76,615,275 (GRCm39) missense probably benign 0.00
R7874:Fstl5 UTSW 3 76,569,093 (GRCm39) missense probably benign 0.10
R7881:Fstl5 UTSW 3 76,443,605 (GRCm39) missense probably damaging 1.00
R7986:Fstl5 UTSW 3 76,337,097 (GRCm39) missense probably damaging 0.98
R8039:Fstl5 UTSW 3 76,555,725 (GRCm39) missense possibly damaging 0.69
R8050:Fstl5 UTSW 3 76,614,810 (GRCm39) missense probably benign 0.00
R8844:Fstl5 UTSW 3 76,337,154 (GRCm39) missense possibly damaging 0.71
R8929:Fstl5 UTSW 3 76,615,138 (GRCm39) missense probably damaging 0.98
R9012:Fstl5 UTSW 3 76,567,027 (GRCm39) missense probably damaging 1.00
R9069:Fstl5 UTSW 3 76,615,416 (GRCm39) missense probably damaging 0.99
R9221:Fstl5 UTSW 3 76,569,114 (GRCm39) missense probably damaging 0.98
R9373:Fstl5 UTSW 3 76,555,669 (GRCm39) nonsense probably null
R9427:Fstl5 UTSW 3 76,229,583 (GRCm39) missense
R9490:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R9603:Fstl5 UTSW 3 76,496,260 (GRCm39) missense probably damaging 1.00
Z1176:Fstl5 UTSW 3 76,615,289 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGGTAATTTCAGTGACAGAACC -3'
(R):5'- AGAATTTGGCCAGCTTTAGTCTC -3'

Sequencing Primer
(F):5'- TCAGTGACAGAACCAAGAATTTATG -3'
(R):5'- GGCCAGCTTTAGTCTCATAAATG -3'
Posted On 2018-10-18