|Institutional Source||Beutler Lab|
|Gene Name||neuronal pentraxin 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6866 (G1)|
|Chromosomal Location||119538719-119547753 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 119546650 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000026670 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000026670]|
|Predicted Effect||probably null
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nptx1||
(F):5'- GTCCTGACTGTACTGTACAATCCC -3'
(R):5'- CAGTACAGCCGCCTCAATTC -3'
(F):5'- ACTGTACTGTACAATCCCTTCTTAAG -3'
(R):5'- AGCCGCCTCAATTCTTCCAG -3'