Incidental Mutation 'IGL01011:Vmn1r6'
ID53606
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r6
Ensembl Gene ENSMUSG00000115701
Gene Namevomeronasal 1 receptor 6
SynonymsV1rc20
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #IGL01011
Quality Score
Status
Chromosome6
Chromosomal Location56997243-57009825 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 57002544 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Valine at position 42 (L42V)
Ref Sequence ENSEMBL: ENSMUSP00000154199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079669] [ENSMUST00000226689] [ENSMUST00000227131] [ENSMUST00000227188] [ENSMUST00000227631] [ENSMUST00000227847] [ENSMUST00000228285]
Predicted Effect probably benign
Transcript: ENSMUST00000079669
AA Change: L64V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078611
Gene: ENSMUSG00000115701
AA Change: L64V

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.9e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226689
AA Change: L64V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227131
AA Change: L64V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227188
AA Change: L42V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000227631
AA Change: L42V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000227847
AA Change: L64V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000228285
AA Change: L64V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik A T 9: 57,258,246 C282S probably damaging Het
Abca12 T C 1: 71,263,632 I2143V probably benign Het
Adgrg6 A C 10: 14,409,798 I1148S probably damaging Het
Aox4 C T 1: 58,240,775 R517* probably null Het
Arnt2 T A 7: 84,285,829 D289V probably benign Het
Atad2b A G 12: 4,965,984 N570S probably benign Het
Aven G A 2: 112,629,785 D208N possibly damaging Het
Bcl9l A G 9: 44,505,179 D183G possibly damaging Het
Cd300lf A G 11: 115,124,333 S144P probably benign Het
Chd8 C A 14: 52,231,532 G543V possibly damaging Het
Chrm2 A G 6: 36,524,438 N410S probably benign Het
Clip4 A G 17: 71,849,939 I590V probably benign Het
Cnbp C T 6: 87,845,700 R27H probably benign Het
Col4a3 T C 1: 82,682,301 V889A unknown Het
Cxcl5 T C 5: 90,760,523 probably benign Het
Dennd6a G T 14: 26,603,054 V171F probably damaging Het
Dhx38 T C 8: 109,562,691 I26V probably benign Het
Dscaml1 A G 9: 45,683,672 D691G possibly damaging Het
Etfdh A T 3: 79,612,061 probably benign Het
Fbn2 G A 18: 58,095,240 probably benign Het
Foxp2 T A 6: 15,438,019 *715R probably null Het
Ftl1 A T 7: 45,458,646 D65E probably benign Het
Galm A G 17: 80,183,280 T289A probably benign Het
Gm20721 A G 2: 174,345,738 D1049G probably damaging Het
Gm28778 T C 1: 53,299,118 V47A probably benign Het
Gm5414 T C 15: 101,628,134 S19G probably benign Het
Hdac7 T A 15: 97,793,935 E835D possibly damaging Het
Hist1h1t C T 13: 23,696,049 L62F probably damaging Het
Hspg2 C T 4: 137,559,335 T3663I probably damaging Het
Kdm4d A T 9: 14,464,219 D114E probably benign Het
Kif5a A T 10: 127,239,196 V516E probably benign Het
Lrrtm1 A G 6: 77,244,235 probably null Het
Miga1 G T 3: 152,276,690 T519K probably benign Het
Mtfr1l G A 4: 134,529,200 P182S probably damaging Het
Myo15 A G 11: 60,476,992 I193V probably benign Het
Myo1e T C 9: 70,316,589 probably benign Het
Olfr190 T A 16: 59,074,430 T217S probably benign Het
Olfr376 A T 11: 73,375,007 Q86L probably benign Het
Olfr541 A T 7: 140,704,437 Y62F probably damaging Het
Pias1 T C 9: 62,912,855 T277A probably benign Het
Slamf6 T A 1: 171,938,099 H263Q probably benign Het
Snrnp48 A G 13: 38,220,764 D202G probably damaging Het
Snx13 T A 12: 35,098,280 D269E probably damaging Het
Tiam2 A T 17: 3,415,028 D344V probably benign Het
Tmem62 G T 2: 120,979,219 K127N possibly damaging Het
Trav15-1-dv6-1 C T 14: 53,560,035 T46I possibly damaging Het
Trav16d-dv11 C T 14: 53,047,584 T39M possibly damaging Het
Trio T C 15: 27,736,489 D2794G probably damaging Het
Trpc7 C T 13: 56,804,540 G551D probably damaging Het
Ttc37 G A 13: 76,122,665 C127Y probably damaging Het
Ttn A G 2: 76,814,290 V11294A possibly damaging Het
Ubap2 G A 4: 41,195,328 probably benign Het
Ubap2l G A 3: 90,009,256 Q915* probably null Het
Ubfd1 A G 7: 122,078,472 E340G probably benign Het
Vil1 T C 1: 74,434,887 probably null Het
Vps13c A G 9: 67,926,955 T1635A probably damaging Het
Zfhx3 T A 8: 108,793,594 H449Q probably benign Het
Zfp750 A T 11: 121,513,096 S318T probably benign Het
Other mutations in Vmn1r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00905:Vmn1r6 APN 6 57002804 missense probably damaging 1.00
IGL01147:Vmn1r6 APN 6 57002641 missense probably damaging 1.00
IGL01475:Vmn1r6 APN 6 57002911 missense probably damaging 1.00
IGL01638:Vmn1r6 APN 6 57003192 nonsense probably null
IGL01860:Vmn1r6 APN 6 57002689 nonsense probably null
IGL01876:Vmn1r6 APN 6 57002461 missense probably benign 0.12
IGL01988:Vmn1r6 APN 6 57002665 missense probably damaging 0.99
R0531:Vmn1r6 UTSW 6 57002598 missense probably benign 0.00
R1495:Vmn1r6 UTSW 6 57003073 missense possibly damaging 0.58
R1733:Vmn1r6 UTSW 6 57002622 missense probably damaging 1.00
R2037:Vmn1r6 UTSW 6 57003124 missense probably damaging 1.00
R3625:Vmn1r6 UTSW 6 57002935 missense probably damaging 0.96
R4353:Vmn1r6 UTSW 6 57002692 missense possibly damaging 0.63
R4484:Vmn1r6 UTSW 6 57003189 missense probably benign
R4854:Vmn1r6 UTSW 6 57002698 missense probably benign 0.00
R5237:Vmn1r6 UTSW 6 57003194 missense probably damaging 1.00
R5341:Vmn1r6 UTSW 6 57002804 missense probably damaging 1.00
R5611:Vmn1r6 UTSW 6 57002377 missense probably damaging 1.00
R6795:Vmn1r6 UTSW 6 57002437 missense possibly damaging 0.85
R8423:Vmn1r6 UTSW 6 57002510 missense probably benign 0.30
Posted On2013-06-28