Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01012:Vmn2r23'

53613

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL01012

Quality Score

Status

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123729596 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 462 (T462A)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

Predicted Effect

probably benign
Transcript: ENSMUST00000172391
AA Change: T462A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: T462A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim3	A	T	18: 61,839,701	M249K	possibly damaging	Het
Adamtsl1	T	C	4: 86,342,189	F879S	possibly damaging	Het
Afap1l2	T	C	19: 56,930,261	E30G	probably damaging	Het
Aqp9	A	G	9: 71,130,549		probably benign	Het
Arhgap17	A	T	7: 123,286,568		probably benign	Het
Arhgef10	T	C	8: 14,979,977	S921P	probably damaging	Het
Atp6v0e2	T	C	6: 48,537,815	I22T	probably damaging	Het
AY074887	C	T	9: 54,950,679		probably benign	Het
Bcl2l15	T	A	3: 103,833,414	D65E	probably damaging	Het
C2cd6	A	T	1: 58,997,348		probably benign	Het
Ccdc138	G	A	10: 58,540,915		probably null	Het
Ccdc7b	A	G	8: 129,178,357	T159A	possibly damaging	Het
Ccser1	A	G	6: 61,638,490	T659A	probably benign	Het
Cd300ld2	T	A	11: 115,012,297	I241F	probably benign	Het
Cep192	T	A	18: 67,812,406	N192K	possibly damaging	Het
Csmd1	T	C	8: 15,917,341	K3174R	probably benign	Het
Dpy30	A	T	17: 74,307,754	L65I	probably damaging	Het
Eci2	A	T	13: 34,990,329	L83*	probably null	Het
F7	A	T	8: 13,033,409	E183V	probably damaging	Het
Fam192a	G	A	8: 94,587,362	R104W	probably damaging	Het
Gabrg1	T	C	5: 70,778,169	K214R	probably benign	Het
Galr2	A	T	11: 116,283,170	T209S	probably damaging	Het
Gimap9	T	C	6: 48,677,917		probably null	Het
Gip	C	A	11: 96,025,459	F28L	probably benign	Het
Gpd2	A	G	2: 57,364,530	N662S	probably benign	Het
Grik2	T	G	10: 49,272,956	D511A	probably damaging	Het
Ift122	T	A	6: 115,899,491	Y563N	probably damaging	Het
Ipo8	A	G	6: 148,789,063		probably benign	Het
Islr	T	C	9: 58,157,228	E332G	probably damaging	Het
Itgb7	G	A	15: 102,227,585	S5L	probably benign	Het
Itpr2	G	A	6: 146,345,161	R1087W	probably damaging	Het
Katnal2	C	A	18: 77,017,554	V66F	probably damaging	Het
Krt81	T	C	15: 101,461,019	D284G	probably benign	Het
Krtap4-8	T	A	11: 99,780,005		probably benign	Het
Map1s	C	A	8: 70,913,910	N486K	probably benign	Het
Med13l	G	A	5: 118,734,028	D842N	probably damaging	Het
Mef2c	T	A	13: 83,655,595	M306K	probably damaging	Het
Myb	C	T	10: 21,146,260	V377I	probably benign	Het
Myocd	C	T	11: 65,184,625	G558R	possibly damaging	Het
Nars	G	T	18: 64,504,968	A305E	probably damaging	Het
Neb	A	T	2: 52,196,361	N5233K	probably benign	Het
Nipsnap2	T	C	5: 129,746,439	I181T	possibly damaging	Het
Olfr1496	T	C	19: 13,781,573		probably benign	Het
Olfr960	A	T	9: 39,623,365	M81L	probably benign	Het
P3h2	A	C	16: 25,987,248	C282G	probably damaging	Het
Pcgf5	T	A	19: 36,442,868	C167S	probably damaging	Het
Pck2	T	C	14: 55,544,069		probably benign	Het
Peli2	C	T	14: 48,252,730	R169*	probably null	Het
Pramef25	T	A	4: 143,950,214		probably benign	Het
Ralgapa2	T	A	2: 146,421,739	Q686L	possibly damaging	Het
Scap	C	A	9: 110,362,420	P50H	probably damaging	Het
Sh3rf2	T	A	18: 42,054,192	D125E	possibly damaging	Het
Slc25a38	T	C	9: 120,116,494		probably benign	Het
Slc35a5	A	G	16: 45,143,832	V346A	probably damaging	Het
Smad4	T	A	18: 73,675,809	N129I	probably damaging	Het
Sod2	C	T	17: 13,013,577	A163V	possibly damaging	Het
Spred3	T	A	7: 29,161,523		probably benign	Het
Stag1	C	A	9: 100,855,859	A423E	possibly damaging	Het
Stk17b	A	T	1: 53,761,037	S261T	probably benign	Het
Stx3	T	C	19: 11,791,788	K58E	probably damaging	Het
Timm10b	C	A	7: 105,641,138	Y79*	probably null	Het
Tmem204	T	C	17: 25,070,355	D97G	probably damaging	Het
Tnfrsf25	T	C	4: 152,118,428	V181A	probably benign	Het
Trim54	T	G	5: 31,136,958	S313A	probably benign	Het
Unc79	T	A	12: 103,112,455	D1433E	probably damaging	Het
Wdr27	T	A	17: 14,926,247	H162L	probably damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123729725	missense	possibly damaging	0.89
IGL01073:Vmn2r23	APN	6	123712800	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123704424	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123704407	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123741886	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123741860	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123741744	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123741836	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123704478	missense	probably benign
IGL02831:Vmn2r23	APN	6	123704385	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123704396	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123741619	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123741782	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123704374	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123729626	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123729721	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123742135	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123742004	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123713270	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123713427	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123729690	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123702915	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123713010	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123741499	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123704425	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123742188	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123713170	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123741389	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123729738	missense	probably benign
R4506:Vmn2r23	UTSW	6	123702925	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123741730	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123741826	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123733349	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123713002	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123733273	missense	probably benign
R5761:Vmn2r23	UTSW	6	123712759	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123712942	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123741895	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123704400	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123712902	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123713425	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123733273	missense	probably benign
R6925:Vmn2r23	UTSW	6	123704553	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123713022	missense	probably benign
R7215:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123741581	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123704579	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123704541	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123741353	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123704640	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123741656	missense	probably damaging	0.99
RF018:Vmn2r23	UTSW	6	123713116	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123713161	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123742108	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123729725	frame shift	probably null

Posted On

2013-06-28