Incidental Mutation 'IGL00592:Tas2r131'
ID5362
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r131
Ensembl Gene ENSMUSG00000057699
Gene Nametaste receptor, type 2, member 131
SynonymsmGR31, Tas2r31, mt2r61, T2R31
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00592
Quality Score
Status
Chromosome6
Chromosomal Location132956884-132957919 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 132957196 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Proline at position 217 (T217P)
Ref Sequence ENSEMBL: ENSMUSP00000080736 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082085]
Predicted Effect probably damaging
Transcript: ENSMUST00000082085
AA Change: T217P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000080736
Gene: ENSMUSG00000057699
AA Change: T217P

DomainStartEndE-ValueType
Pfam:TAS2R 1 293 1.2e-66 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh4 A G 3: 138,420,636 I91V probably damaging Het
Ak6 T C 13: 100,664,091 V74A probably benign Het
Antxr1 C A 6: 87,288,802 V110F probably damaging Het
Anxa1 T C 19: 20,377,669 D247G probably benign Het
Dgkg T C 16: 22,479,362 probably benign Het
Eva1b T C 4: 126,149,650 M161T probably benign Het
Fbxw22 C A 9: 109,384,040 V280F possibly damaging Het
Klhl9 A G 4: 88,721,141 S288P probably damaging Het
Masp2 C T 4: 148,602,729 P23S probably benign Het
Ncam1 T A 9: 49,523,565 D600V probably damaging Het
Pcnx4 A G 12: 72,579,365 N1115S probably damaging Het
Pdia2 A G 17: 26,198,116 V109A probably damaging Het
Pla1a G T 16: 38,414,850 H161N probably damaging Het
Prokr2 A T 2: 132,381,504 D39E probably benign Het
Sall4 T C 2: 168,755,963 D319G probably damaging Het
Sgms2 A G 3: 131,341,833 S131P possibly damaging Het
Slc22a2 A T 17: 12,608,418 Q319L possibly damaging Het
Slc27a5 A G 7: 12,988,639 I636T probably benign Het
Trh T C 6: 92,242,742 M198V possibly damaging Het
Ube2b A C 11: 51,986,719 V141G probably damaging Het
Ube2l6 T A 2: 84,809,029 V112E probably damaging Het
Vmn1r79 T C 7: 12,177,007 I272T probably benign Het
Xylb C T 9: 119,390,483 Q513* probably null Het
Zbtb4 T A 11: 69,776,731 C287* probably null Het
Other mutations in Tas2r131
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00795:Tas2r131 APN 6 132957591 missense possibly damaging 0.94
IGL01023:Tas2r131 APN 6 132957801 missense probably damaging 1.00
IGL02439:Tas2r131 APN 6 132957769 missense probably damaging 1.00
R0335:Tas2r131 UTSW 6 132957829 missense probably benign
R0523:Tas2r131 UTSW 6 132957451 missense possibly damaging 0.71
R1056:Tas2r131 UTSW 6 132957067 missense possibly damaging 0.68
R1069:Tas2r131 UTSW 6 132957825 missense probably benign 0.01
R4073:Tas2r131 UTSW 6 132957839 nonsense probably null
R4719:Tas2r131 UTSW 6 132956973 missense probably damaging 1.00
R5002:Tas2r131 UTSW 6 132957151 missense probably benign 0.00
R5049:Tas2r131 UTSW 6 132957577 missense probably damaging 1.00
R5635:Tas2r131 UTSW 6 132957608 missense probably benign 0.27
R5905:Tas2r131 UTSW 6 132957676 missense probably benign 0.02
R6028:Tas2r131 UTSW 6 132957676 missense probably benign 0.02
R6229:Tas2r131 UTSW 6 132957022 missense probably damaging 1.00
R7115:Tas2r131 UTSW 6 132957604 missense probably benign 0.07
R7561:Tas2r131 UTSW 6 132956958 missense probably benign 0.26
R7741:Tas2r131 UTSW 6 132957475 missense possibly damaging 0.60
R7810:Tas2r131 UTSW 6 132957742 missense probably benign 0.11
X0025:Tas2r131 UTSW 6 132957538 missense probably damaging 1.00
Posted On2012-04-20