Incidental Mutation 'R6875:Il36g'
ID 536348
Institutional Source Beutler Lab
Gene Symbol Il36g
Ensembl Gene ENSMUSG00000044103
Gene Name interleukin 36G
Synonyms IL-36gamma, If36g, Il1f9
MMRRC Submission 044971-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R6875 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 24076488-24083579 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) G to C at 24078633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000053391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057567]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000057567
SMART Domains Protein: ENSMUSP00000053391
Gene: ENSMUSG00000044103

DomainStartEndE-ValueType
IL1 43 190 7.91e-5 SMART
Meta Mutation Damage Score 0.9482 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030458C11Rik T C 15: 12,812,154 (GRCm39) H270R probably damaging Het
Abcb1a T C 5: 8,751,628 (GRCm39) I336T probably benign Het
Adam19 T A 11: 46,003,702 (GRCm39) F177I probably benign Het
Ankrd53 T C 6: 83,745,155 (GRCm39) V455A probably damaging Het
Arrdc1 A G 2: 24,815,677 (GRCm39) S415P probably benign Het
Atp10a T C 7: 58,447,100 (GRCm39) L614P probably benign Het
Catsper1 G T 19: 5,393,991 (GRCm39) V668F probably damaging Het
Cluh T A 11: 74,552,744 (GRCm39) D596E probably damaging Het
Cnot10 A G 9: 114,444,175 (GRCm39) S407P probably benign Het
Commd6 T C 14: 101,871,786 (GRCm39) T86A probably damaging Het
D5Ertd579e A T 5: 36,762,001 (GRCm39) probably null Het
Eif3l A G 15: 78,969,760 (GRCm39) D252G probably damaging Het
Epha2 A T 4: 141,055,779 (GRCm39) S962C probably damaging Het
Fcho1 C A 8: 72,167,069 (GRCm39) probably null Het
Fgf23 G T 6: 127,050,179 (GRCm39) G63C probably damaging Het
Flnc A T 6: 29,445,748 (GRCm39) Y834F probably damaging Het
Gcn1 T C 5: 115,726,169 (GRCm39) L608P probably damaging Het
Hdac5 T A 11: 102,093,102 (GRCm39) E545V probably damaging Het
Hecw2 A T 1: 53,976,291 (GRCm39) M166K probably benign Het
Ikbkb T C 8: 23,155,909 (GRCm39) D586G probably damaging Het
Ipo13 A T 4: 117,762,108 (GRCm39) I422N possibly damaging Het
Iqgap3 GGAGAG GGAG 3: 88,020,078 (GRCm39) probably null Het
Kat6a G A 8: 23,422,377 (GRCm39) A896T probably benign Het
Kif28 A G 1: 179,563,559 (GRCm39) I139T probably damaging Het
Klhl25 A G 7: 75,516,090 (GRCm39) E332G probably damaging Het
Krt8 C T 15: 101,906,343 (GRCm39) A389T probably benign Het
Msrb3 T C 10: 120,620,011 (GRCm39) S175G probably benign Het
Muc5ac C T 7: 141,363,481 (GRCm39) probably benign Het
Myo10 T C 15: 25,805,745 (GRCm39) Y1709H probably benign Het
Nckap5 A G 1: 125,950,931 (GRCm39) S1519P probably benign Het
Npnt T A 3: 132,615,671 (GRCm39) D124V probably damaging Het
Nr1d1 A T 11: 98,661,662 (GRCm39) probably null Het
Ogdh A G 11: 6,290,477 (GRCm39) Y365C probably benign Het
Or4f56 A T 2: 111,703,306 (GRCm39) I298N possibly damaging Het
Phf21b A T 15: 84,671,647 (GRCm39) C416S probably damaging Het
Prpsap1 A G 11: 116,362,264 (GRCm39) S373P probably damaging Het
Qrfprl A T 6: 65,433,320 (GRCm39) N380I probably benign Het
Rab28 T C 5: 41,860,877 (GRCm39) T26A probably damaging Het
Rbbp8nl A G 2: 179,921,019 (GRCm39) I455T probably benign Het
Rnft2 G A 5: 118,366,883 (GRCm39) A285V possibly damaging Het
Rrp36 G T 17: 46,983,297 (GRCm39) Q106K probably benign Het
Rsf1 CG CGACGGCGGAG 7: 97,229,115 (GRCm39) probably benign Het
Runx2 G A 17: 45,125,079 (GRCm39) P80L probably damaging Het
Scn5a A G 9: 119,315,710 (GRCm39) L1666P probably damaging Het
Siglecf A C 7: 43,004,624 (GRCm39) T318P probably benign Het
Slc22a1 C T 17: 12,886,192 (GRCm39) W147* probably null Het
Smchd1 T C 17: 71,660,501 (GRCm39) I1868V probably damaging Het
Snx21 A G 2: 164,633,822 (GRCm39) S203G probably damaging Het
Srl T C 16: 4,300,695 (GRCm39) K792R probably benign Het
Srrt A G 5: 137,296,935 (GRCm39) F100S probably benign Het
Stard9 G T 2: 120,527,917 (GRCm39) M1391I probably benign Het
Syne2 A G 12: 76,082,404 (GRCm39) E119G probably damaging Het
Syt11 G T 3: 88,669,462 (GRCm39) S143R possibly damaging Het
Tiparp T A 3: 65,439,063 (GRCm39) H126Q probably benign Het
Tulp2 C A 7: 45,168,038 (GRCm39) T150K probably benign Het
Ugt2b37 T A 5: 87,390,288 (GRCm39) Y386F probably benign Het
Usp31 C T 7: 121,248,863 (GRCm39) W860* probably null Het
Zfp317 A G 9: 19,554,961 (GRCm39) R30G probably damaging Het
Zfp709 C A 8: 72,642,851 (GRCm39) N93K possibly damaging Het
Other mutations in Il36g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02027:Il36g APN 2 24,082,797 (GRCm39) missense probably benign 0.06
IGL03190:Il36g APN 2 24,077,272 (GRCm39) nonsense probably null
IGL03047:Il36g UTSW 2 24,082,719 (GRCm39) missense probably damaging 1.00
R2384:Il36g UTSW 2 24,082,660 (GRCm39) missense probably benign 0.43
R5158:Il36g UTSW 2 24,082,798 (GRCm39) missense probably damaging 0.99
R5916:Il36g UTSW 2 24,082,806 (GRCm39) makesense probably null
R8187:Il36g UTSW 2 24,082,617 (GRCm39) missense probably damaging 1.00
R8357:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
R8457:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- ATGAGAATGTAGCTCCTGCCC -3'
(R):5'- GAAACCCACTGCTTTATATGCTAAC -3'

Sequencing Primer
(F):5'- CCCAACAGCTAGGTCAGGATG -3'
(R):5'- GGGTGTCCATTAACTTCC -3'
Posted On 2018-10-18