Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01024:Vmn2r22'

53636

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r22

Ensembl Gene

ENSMUSG00000095486

Gene Name

vomeronasal 2, receptor 22

Synonyms

EG546913

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL01024

Quality Score

Status

Chromosome

Chromosomal Location

123586717-123627594 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123615012 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 193 (F193L)

Ref Sequence

ENSEMBL: ENSMUSP00000132043 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170808]

AlphaFold

E9Q7S8

Predicted Effect

probably damaging
Transcript: ENSMUST00000170808
AA Change: F193L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: F193L

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	81	473	1.4e-32	PFAM
Pfam:NCD3G	517	570	2.2e-23	PFAM
Pfam:7tm_3	601	838	1.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810055G02Rik	T	C	19: 3,767,040 (GRCm39)	V209A	probably benign	Het
Abca6	T	A	11: 110,087,968 (GRCm39)	Y1053F	probably benign	Het
Acot12	C	T	13: 91,929,330 (GRCm39)	Q386*	probably null	Het
Adamts16	A	G	13: 70,943,603 (GRCm39)	V336A	probably benign	Het
Ankrd49	A	G	9: 14,694,099 (GRCm39)	F23L	probably damaging	Het
Aspm	A	T	1: 139,405,862 (GRCm39)	H1583L	possibly damaging	Het
Atp6v0a1	A	G	11: 100,939,265 (GRCm39)	I677V	probably benign	Het
Brinp1	A	T	4: 68,680,731 (GRCm39)	W600R	probably damaging	Het
Ccdc185	T	C	1: 182,574,988 (GRCm39)	E567G	possibly damaging	Het
Clip2	T	C	5: 134,539,066 (GRCm39)	D445G	probably damaging	Het
Elp5	T	C	11: 69,859,248 (GRCm39)		probably benign	Het
Gm9376	A	G	14: 118,504,570 (GRCm39)	M1V	probably null	Het
Gtf2a1l	A	G	17: 88,978,719 (GRCm39)	K40R	probably damaging	Het
Hdc	A	G	2: 126,445,766 (GRCm39)	V246A	probably benign	Het
Hectd2	T	A	19: 36,583,793 (GRCm39)	F479L	probably damaging	Het
Hipk1	G	T	3: 103,667,952 (GRCm39)	N538K	probably benign	Het
Kif27	T	A	13: 58,436,015 (GRCm39)	E1259D	possibly damaging	Het
Klhdc2	T	A	12: 69,352,610 (GRCm39)	N256K	probably benign	Het
Krt71	C	T	15: 101,645,109 (GRCm39)	A401T	probably damaging	Het
Mapk3	A	T	7: 126,363,946 (GRCm39)	K312*	probably null	Het
Med12l	G	T	3: 58,980,762 (GRCm39)	S365I	probably damaging	Het
Mgam	A	G	6: 40,619,944 (GRCm39)	K11R	probably benign	Het
Nox3	A	T	17: 3,733,290 (GRCm39)	I187N	probably damaging	Het
Nudcd1	T	A	15: 44,284,222 (GRCm39)	M55L	probably benign	Het
Or1a1b	A	T	11: 74,097,481 (GRCm39)	L187Q	probably damaging	Het
Or4f59	A	T	2: 111,872,716 (GRCm39)	F220L	probably benign	Het
Or8b57	A	G	9: 40,004,029 (GRCm39)	S78P	probably damaging	Het
Pard6g	T	C	18: 80,123,037 (GRCm39)		probably benign	Het
Pbrm1	G	A	14: 30,774,217 (GRCm39)	R461H	probably damaging	Het
Ppm1f	C	A	16: 16,741,633 (GRCm39)	T369K	probably benign	Het
Ppp1r16b	C	T	2: 158,582,736 (GRCm39)		probably benign	Het
Pramel29	A	T	4: 143,935,045 (GRCm39)	I232K	possibly damaging	Het
Prom2	T	C	2: 127,383,059 (GRCm39)	N61S	probably benign	Het
Psmc2	T	C	5: 22,006,196 (GRCm39)		probably benign	Het
Psme2	A	G	14: 55,825,893 (GRCm39)		probably benign	Het
Ptprc	T	C	1: 138,008,650 (GRCm39)	H655R	probably damaging	Het
Pxdn	A	C	12: 30,037,098 (GRCm39)	N292T	probably damaging	Het
Rapgef2	T	C	3: 78,977,445 (GRCm39)	I1301V	probably benign	Het
Rnase11	T	C	14: 51,287,321 (GRCm39)	I78V	probably benign	Het
Rpl41	A	G	10: 128,384,246 (GRCm39)		probably benign	Het
Sgf29	G	A	7: 126,264,103 (GRCm39)	R56Q	possibly damaging	Het
Sis	A	G	3: 72,819,209 (GRCm39)	L1449S	probably damaging	Het
Slc34a2	T	A	5: 53,224,972 (GRCm39)	V371D	possibly damaging	Het
Son	C	A	16: 91,452,798 (GRCm39)	T515K	probably damaging	Het
Tbx15	A	T	3: 99,223,562 (GRCm39)	D250V	probably damaging	Het
Thoc2l	T	G	5: 104,669,612 (GRCm39)	V1378G	probably benign	Het
Tmem171	T	A	13: 98,823,026 (GRCm39)		probably null	Het
Ugt2b36	C	T	5: 87,228,728 (GRCm39)		probably null	Het
Vill	G	A	9: 118,899,418 (GRCm39)		probably null	Het
Vmn2r95	C	T	17: 18,672,590 (GRCm39)		probably benign	Het
Vstm2a	T	A	11: 16,231,874 (GRCm39)	V223D	possibly damaging	Het

Other mutations in Vmn2r22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01764:Vmn2r22	APN	6	123,627,379 (GRCm39)	critical splice donor site	probably null
IGL02037:Vmn2r22	APN	6	123,626,026 (GRCm39)	missense	probably damaging	1.00
IGL02183:Vmn2r22	APN	6	123,614,963 (GRCm39)	missense	probably damaging	1.00
IGL02335:Vmn2r22	APN	6	123,615,051 (GRCm39)	missense	probably damaging	0.99
IGL02440:Vmn2r22	APN	6	123,614,364 (GRCm39)	missense	probably benign	0.00
IGL02663:Vmn2r22	APN	6	123,626,117 (GRCm39)	missense	probably benign	0.11
IGL03101:Vmn2r22	APN	6	123,614,295 (GRCm39)	missense	probably benign	0.09
R0266:Vmn2r22	UTSW	6	123,614,363 (GRCm39)	missense	probably damaging	0.99
R0348:Vmn2r22	UTSW	6	123,614,684 (GRCm39)	missense	probably damaging	1.00
R0780:Vmn2r22	UTSW	6	123,614,933 (GRCm39)	missense	probably damaging	1.00
R0849:Vmn2r22	UTSW	6	123,614,363 (GRCm39)	missense	probably damaging	0.99
R1074:Vmn2r22	UTSW	6	123,626,217 (GRCm39)	missense	probably benign	0.02
R1456:Vmn2r22	UTSW	6	123,614,624 (GRCm39)	missense	possibly damaging	0.86
R1719:Vmn2r22	UTSW	6	123,614,802 (GRCm39)	missense	possibly damaging	0.68
R1989:Vmn2r22	UTSW	6	123,614,500 (GRCm39)	missense	probably damaging	1.00
R2928:Vmn2r22	UTSW	6	123,614,402 (GRCm39)	missense	probably damaging	0.96
R2939:Vmn2r22	UTSW	6	123,614,594 (GRCm39)	missense	probably damaging	0.99
R3727:Vmn2r22	UTSW	6	123,627,584 (GRCm39)	missense	possibly damaging	0.70
R3782:Vmn2r22	UTSW	6	123,627,591 (GRCm39)	nonsense	probably null
R3873:Vmn2r22	UTSW	6	123,614,339 (GRCm39)	missense	possibly damaging	0.68
R4344:Vmn2r22	UTSW	6	123,614,756 (GRCm39)	missense	probably damaging	1.00
R4407:Vmn2r22	UTSW	6	123,614,913 (GRCm39)	missense	probably damaging	1.00
R4428:Vmn2r22	UTSW	6	123,614,817 (GRCm39)	missense	possibly damaging	0.47
R4430:Vmn2r22	UTSW	6	123,614,817 (GRCm39)	missense	possibly damaging	0.47
R4431:Vmn2r22	UTSW	6	123,614,817 (GRCm39)	missense	possibly damaging	0.47
R4701:Vmn2r22	UTSW	6	123,627,428 (GRCm39)	missense	probably benign	0.00
R5274:Vmn2r22	UTSW	6	123,627,593 (GRCm39)	start codon destroyed	probably null	0.93
R5668:Vmn2r22	UTSW	6	123,614,873 (GRCm39)	missense	probably benign	0.06
R5776:Vmn2r22	UTSW	6	123,614,673 (GRCm39)	missense	probably damaging	1.00
R6416:Vmn2r22	UTSW	6	123,614,697 (GRCm39)	missense	probably damaging	1.00
R7788:Vmn2r22	UTSW	6	123,614,559 (GRCm39)	missense	not run
R8208:Vmn2r22	UTSW	6	123,614,444 (GRCm39)	missense	probably damaging	1.00
R8267:Vmn2r22	UTSW	6	123,615,000 (GRCm39)	missense	possibly damaging	0.81
R8400:Vmn2r22	UTSW	6	123,614,486 (GRCm39)	nonsense	probably null
R8814:Vmn2r22	UTSW	6	123,614,789 (GRCm39)	missense	probably damaging	0.96
R8850:Vmn2r22	UTSW	6	123,614,454 (GRCm39)	missense	probably damaging	1.00
R9613:Vmn2r22	UTSW	6	123,615,075 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-06-28