Mutagenetix > Incidental Mutation

Incidental Mutation 'R6875:Flnc'

536367

Institutional Source

Beutler Lab

Gene Symbol

Flnc

Ensembl Gene

ENSMUSG00000068699

Gene Name

filamin C, gamma

Synonyms

1110055E19Rik, actin binding protein 280, Fln2

MMRRC Submission

044971-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6875 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

29433256-29461883 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 29445749 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 834 (Y834F)

Ref Sequence

ENSEMBL: ENSMUSP00000099139 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065090] [ENSMUST00000101617]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000065090
AA Change: Y834F

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000064163
Gene: ENSMUSG00000068699
AA Change: Y834F

Domain	Start	End	E-Value	Type
CH	39	141	1.17e-25	SMART
CH	162	258	2.09e-22	SMART
IG_FLMN	275	372	3.84e-38	SMART
IG_FLMN	375	472	3.73e-36	SMART
IG_FLMN	474	569	4.41e-38	SMART
IG_FLMN	571	662	3.61e-34	SMART
IG_FLMN	667	762	2.48e-41	SMART
IG_FLMN	764	865	6.7e-29	SMART
IG_FLMN	867	964	3.42e-35	SMART
IG_FLMN	966	1060	2.92e-29	SMART
IG_FLMN	1062	1153	3.69e-40	SMART
IG_FLMN	1155	1248	6.53e-41	SMART
IG_FLMN	1250	1348	7.23e-34	SMART
IG_FLMN	1350	1441	2.04e-42	SMART
IG_FLMN	1443	1537	1.75e-41	SMART
IG_FLMN	1539	1634	1.31e-40	SMART
IG_FLMN	1636	1738	1.05e-30	SMART
IG_FLMN	1777	1858	2.93e-11	SMART
IG_FLMN	1859	1950	2.55e-43	SMART
IG_FLMN	1951	2037	2.43e-17	SMART
IG_FLMN	2041	2132	1.52e-41	SMART
PDB:2E9I\|A	2133	2162	3e-7	PDB
IG_FLMN	2217	2310	2.93e-11	SMART
IG_FLMN	2314	2405	1.67e-38	SMART
IG_FLMN	2408	2500	2.56e-25	SMART
IG_FLMN	2505	2596	9.54e-34	SMART
low complexity region	2618	2628	N/A	INTRINSIC
IG_FLMN	2635	2737	2.11e-26	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000101617
AA Change: Y834F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000099139
Gene: ENSMUSG00000068699
AA Change: Y834F

Domain	Start	End	E-Value	Type
CH	39	141	1.17e-25	SMART
CH	162	258	2.09e-22	SMART
IG_FLMN	275	372	3.84e-38	SMART
IG_FLMN	375	472	3.73e-36	SMART
IG_FLMN	474	569	4.41e-38	SMART
IG_FLMN	571	662	3.61e-34	SMART
IG_FLMN	667	762	2.48e-41	SMART
IG_FLMN	764	865	6.7e-29	SMART
IG_FLMN	867	964	3.42e-35	SMART
IG_FLMN	966	1060	2.92e-29	SMART
IG_FLMN	1062	1153	3.69e-40	SMART
IG_FLMN	1155	1248	6.53e-41	SMART
IG_FLMN	1250	1348	7.23e-34	SMART
IG_FLMN	1350	1441	2.04e-42	SMART
IG_FLMN	1443	1537	1.75e-41	SMART
IG_FLMN	1539	1634	1.31e-40	SMART
IG_FLMN	1636	1738	6.11e-32	SMART
IG_FLMN	1744	1825	2.93e-11	SMART
IG_FLMN	1826	1917	2.55e-43	SMART
IG_FLMN	1918	2004	2.43e-17	SMART
IG_FLMN	2008	2099	1.52e-41	SMART
PDB:2E9I\|A	2100	2129	3e-7	PDB
IG_FLMN	2184	2277	2.93e-11	SMART
IG_FLMN	2281	2372	1.67e-38	SMART
IG_FLMN	2375	2467	2.56e-25	SMART
IG_FLMN	2472	2563	9.54e-34	SMART
low complexity region	2585	2595	N/A	INTRINSIC
IG_FLMN	2602	2704	2.11e-26	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.2%

Validation Efficiency

98% (58/59)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a hypomorphic allele display neonatal lethality, respiratory failure, reduced skeletal muscle mass, and abnormal skeletal muscle fiber morphology. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6030458C11Rik	T	C	15: 12,812,068 (GRCm38)	H270R	probably damaging	Het
Abcb1a	T	C	5: 8,701,628 (GRCm38)	I336T	probably benign	Het
Adam19	T	A	11: 46,112,875 (GRCm38)	F177I	probably benign	Het
Ankrd53	T	C	6: 83,768,173 (GRCm38)	V455A	probably damaging	Het
Arrdc1	A	G	2: 24,925,665 (GRCm38)	S415P	probably benign	Het
Atp10a	T	C	7: 58,797,352 (GRCm38)	L614P	probably benign	Het
Catsper1	G	T	19: 5,343,963 (GRCm38)	V668F	probably damaging	Het
Cluh	T	A	11: 74,661,918 (GRCm38)	D596E	probably damaging	Het
Cnot10	A	G	9: 114,615,107 (GRCm38)	S407P	probably benign	Het
Commd6	T	C	14: 101,634,350 (GRCm38)	T86A	probably damaging	Het
D5Ertd579e	A	T	5: 36,604,657 (GRCm38)		probably null	Het
Eif3l	A	G	15: 79,085,560 (GRCm38)	D252G	probably damaging	Het
Epha2	A	T	4: 141,328,468 (GRCm38)	S962C	probably damaging	Het
Fcho1	C	A	8: 71,714,425 (GRCm38)		probably null	Het
Fgf23	G	T	6: 127,073,216 (GRCm38)	G63C	probably damaging	Het
Gcn1	T	C	5: 115,588,110 (GRCm38)	L608P	probably damaging	Het
Hdac5	T	A	11: 102,202,276 (GRCm38)	E545V	probably damaging	Het
Hecw2	A	T	1: 53,937,132 (GRCm38)	M166K	probably benign	Het
Ikbkb	T	C	8: 22,665,893 (GRCm38)	D586G	probably damaging	Het
Il1f9	G	C	2: 24,188,621 (GRCm38)		probably null	Het
Ipo13	A	T	4: 117,904,911 (GRCm38)	I422N	possibly damaging	Het
Iqgap3	GGAGAG	GGAG	3: 88,112,771 (GRCm38)		probably null	Het
Kat6a	G	A	8: 22,932,361 (GRCm38)	A896T	probably benign	Het
Kif28	A	G	1: 179,735,994 (GRCm38)	I139T	probably damaging	Het
Klhl25	A	G	7: 75,866,342 (GRCm38)	E332G	probably damaging	Het
Krt8	C	T	15: 101,997,908 (GRCm38)	A389T	probably benign	Het
Msrb3	T	C	10: 120,784,106 (GRCm38)	S175G	probably benign	Het
Muc5ac	C	T	7: 141,809,744 (GRCm38)		probably benign	Het
Myo10	T	C	15: 25,805,659 (GRCm38)	Y1709H	probably benign	Het
Nckap5	A	G	1: 126,023,194 (GRCm38)	S1519P	probably benign	Het
Npnt	T	A	3: 132,909,910 (GRCm38)	D124V	probably damaging	Het
Nr1d1	A	T	11: 98,770,836 (GRCm38)		probably null	Het
Ogdh	A	G	11: 6,340,477 (GRCm38)	Y365C	probably benign	Het
Or4f56	A	T	2: 111,872,961 (GRCm38)	I298N	possibly damaging	Het
Phf21b	A	T	15: 84,787,446 (GRCm38)	C416S	probably damaging	Het
Prpsap1	A	G	11: 116,471,438 (GRCm38)	S373P	probably damaging	Het
Qrfprl	A	T	6: 65,456,336 (GRCm38)	N380I	probably benign	Het
Rab28	T	C	5: 41,703,534 (GRCm38)	T26A	probably damaging	Het
Rbbp8nl	A	G	2: 180,279,226 (GRCm38)	I455T	probably benign	Het
Rnft2	G	A	5: 118,228,818 (GRCm38)	A285V	possibly damaging	Het
Rrp36	G	T	17: 46,672,371 (GRCm38)	Q106K	probably benign	Het
Rsf1	CG	CGACGGCGGAG	7: 97,579,908 (GRCm38)		probably benign	Het
Runx2	G	A	17: 44,814,192 (GRCm38)	P80L	probably damaging	Het
Scn5a	A	G	9: 119,486,644 (GRCm38)	L1666P	probably damaging	Het
Siglecf	A	C	7: 43,355,200 (GRCm38)	T318P	probably benign	Het
Slc22a1	C	T	17: 12,667,305 (GRCm38)	W147*	probably null	Het
Smchd1	T	C	17: 71,353,506 (GRCm38)	I1868V	probably damaging	Het
Snx21	A	G	2: 164,791,902 (GRCm38)	S203G	probably damaging	Het
Srl	T	C	16: 4,482,831 (GRCm38)	K792R	probably benign	Het
Srrt	A	G	5: 137,298,673 (GRCm38)	F100S	probably benign	Het
Stard9	G	T	2: 120,697,436 (GRCm38)	M1391I	probably benign	Het
Syne2	A	G	12: 76,035,630 (GRCm38)	E119G	probably damaging	Het
Syt11	G	T	3: 88,762,155 (GRCm38)	S143R	possibly damaging	Het
Tiparp	T	A	3: 65,531,642 (GRCm38)	H126Q	probably benign	Het
Tulp2	C	A	7: 45,518,614 (GRCm38)	T150K	probably benign	Het
Ugt2b37	T	A	5: 87,242,429 (GRCm38)	Y386F	probably benign	Het
Usp31	C	T	7: 121,649,640 (GRCm38)	W860*	probably null	Het
Zfp317	A	G	9: 19,643,665 (GRCm38)	R30G	probably damaging	Het
Zfp709	C	A	8: 71,889,007 (GRCm38)	N93K	possibly damaging	Het

Other mutations in Flnc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00952:Flnc	APN	6	29,459,547 (GRCm38)	nonsense	probably null
IGL01099:Flnc	APN	6	29,433,618 (GRCm38)	missense	probably damaging	0.99
IGL01656:Flnc	APN	6	29,443,508 (GRCm38)	splice site	probably benign
IGL01659:Flnc	APN	6	29,448,671 (GRCm38)	missense	probably damaging	0.98
IGL01780:Flnc	APN	6	29,438,493 (GRCm38)	nonsense	probably null
IGL01935:Flnc	APN	6	29,454,280 (GRCm38)	missense	probably damaging	1.00
IGL02039:Flnc	APN	6	29,450,719 (GRCm38)	missense	probably benign	0.05
IGL02119:Flnc	APN	6	29,447,512 (GRCm38)	missense	probably damaging	0.98
IGL02122:Flnc	APN	6	29,444,336 (GRCm38)	missense	possibly damaging	0.70
IGL02236:Flnc	APN	6	29,454,376 (GRCm38)	missense	probably damaging	1.00
IGL02350:Flnc	APN	6	29,438,493 (GRCm38)	nonsense	probably null
IGL02357:Flnc	APN	6	29,438,493 (GRCm38)	nonsense	probably null
IGL02428:Flnc	APN	6	29,451,485 (GRCm38)	missense	probably damaging	1.00
IGL02496:Flnc	APN	6	29,440,685 (GRCm38)	missense	probably damaging	0.98
IGL02516:Flnc	APN	6	29,450,841 (GRCm38)	missense	probably damaging	0.99
IGL02696:Flnc	APN	6	29,446,698 (GRCm38)	missense	probably damaging	0.98
IGL03165:Flnc	APN	6	29,449,378 (GRCm38)	missense	probably damaging	1.00
IGL03190:Flnc	APN	6	29,445,637 (GRCm38)	splice site	probably benign
I1329:Flnc	UTSW	6	29,451,415 (GRCm38)	missense	probably damaging	1.00
R0111:Flnc	UTSW	6	29,454,340 (GRCm38)	missense	probably damaging	0.99
R0665:Flnc	UTSW	6	29,455,531 (GRCm38)	missense	probably damaging	1.00
R0748:Flnc	UTSW	6	29,446,344 (GRCm38)	missense	probably damaging	0.99
R0960:Flnc	UTSW	6	29,441,512 (GRCm38)	missense	probably damaging	1.00
R1328:Flnc	UTSW	6	29,438,613 (GRCm38)	missense	probably damaging	1.00
R1502:Flnc	UTSW	6	29,438,694 (GRCm38)	missense	probably benign	0.45
R1544:Flnc	UTSW	6	29,444,080 (GRCm38)	missense	probably benign	0.00
R1565:Flnc	UTSW	6	29,455,171 (GRCm38)	missense	probably damaging	1.00
R1640:Flnc	UTSW	6	29,433,807 (GRCm38)	missense	possibly damaging	0.78
R1691:Flnc	UTSW	6	29,441,214 (GRCm38)	missense	probably benign	0.09
R1818:Flnc	UTSW	6	29,457,448 (GRCm38)	missense	probably damaging	1.00
R1826:Flnc	UTSW	6	29,455,185 (GRCm38)	missense	probably damaging	0.99
R1851:Flnc	UTSW	6	29,443,479 (GRCm38)	missense	probably damaging	1.00
R1898:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R1905:Flnc	UTSW	6	29,459,460 (GRCm38)	missense	probably damaging	1.00
R1985:Flnc	UTSW	6	29,444,416 (GRCm38)	splice site	probably benign
R2016:Flnc	UTSW	6	29,443,797 (GRCm38)	critical splice donor site	probably null
R2017:Flnc	UTSW	6	29,443,797 (GRCm38)	critical splice donor site	probably null
R2020:Flnc	UTSW	6	29,444,363 (GRCm38)	missense	probably damaging	0.97
R2104:Flnc	UTSW	6	29,450,735 (GRCm38)	critical splice donor site	probably null
R2132:Flnc	UTSW	6	29,443,676 (GRCm38)	missense	probably damaging	1.00
R2141:Flnc	UTSW	6	29,448,675 (GRCm38)	missense	probably damaging	1.00
R2197:Flnc	UTSW	6	29,459,135 (GRCm38)	missense	probably damaging	1.00
R2202:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2203:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2204:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2205:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2209:Flnc	UTSW	6	29,455,845 (GRCm38)	missense	possibly damaging	0.91
R2248:Flnc	UTSW	6	29,451,401 (GRCm38)	missense	probably damaging	0.99
R2258:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2259:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2280:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2281:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2873:Flnc	UTSW	6	29,447,543 (GRCm38)	missense	probably damaging	0.96
R2900:Flnc	UTSW	6	29,448,585 (GRCm38)	missense	probably damaging	0.98
R3788:Flnc	UTSW	6	29,454,057 (GRCm38)	missense	probably damaging	0.99
R3799:Flnc	UTSW	6	29,443,739 (GRCm38)	missense	probably damaging	1.00
R3801:Flnc	UTSW	6	29,447,404 (GRCm38)	missense	probably damaging	0.98
R3851:Flnc	UTSW	6	29,453,719 (GRCm38)	missense	probably damaging	1.00
R3910:Flnc	UTSW	6	29,459,427 (GRCm38)	missense	probably damaging	1.00
R3982:Flnc	UTSW	6	29,442,941 (GRCm38)	missense	probably damaging	1.00
R3983:Flnc	UTSW	6	29,442,941 (GRCm38)	missense	probably damaging	1.00
R4023:Flnc	UTSW	6	29,451,635 (GRCm38)	missense	possibly damaging	0.95
R4676:Flnc	UTSW	6	29,445,154 (GRCm38)	splice site	probably null
R4694:Flnc	UTSW	6	29,443,448 (GRCm38)	missense	probably damaging	1.00
R4695:Flnc	UTSW	6	29,440,429 (GRCm38)	missense	probably damaging	0.99
R4735:Flnc	UTSW	6	29,455,813 (GRCm38)	missense	probably damaging	1.00
R4773:Flnc	UTSW	6	29,445,039 (GRCm38)	missense	possibly damaging	0.96
R4828:Flnc	UTSW	6	29,455,167 (GRCm38)	missense	probably damaging	1.00
R4856:Flnc	UTSW	6	29,447,890 (GRCm38)	missense	probably damaging	1.00
R4879:Flnc	UTSW	6	29,460,806 (GRCm38)	missense	probably damaging	0.99
R4899:Flnc	UTSW	6	29,446,843 (GRCm38)	missense	probably benign	0.17
R4906:Flnc	UTSW	6	29,447,525 (GRCm38)	missense	probably damaging	0.99
R5089:Flnc	UTSW	6	29,447,813 (GRCm38)	missense	probably damaging	0.96
R5173:Flnc	UTSW	6	29,455,538 (GRCm38)	missense	probably damaging	1.00
R5174:Flnc	UTSW	6	29,448,894 (GRCm38)	missense	possibly damaging	0.91
R5290:Flnc	UTSW	6	29,457,554 (GRCm38)	missense	probably damaging	1.00
R5338:Flnc	UTSW	6	29,444,064 (GRCm38)	missense	possibly damaging	0.47
R5352:Flnc	UTSW	6	29,449,318 (GRCm38)	missense	possibly damaging	0.85
R5397:Flnc	UTSW	6	29,441,161 (GRCm38)	missense	possibly damaging	0.87
R5431:Flnc	UTSW	6	29,456,384 (GRCm38)	missense	possibly damaging	0.74
R5481:Flnc	UTSW	6	29,441,217 (GRCm38)	missense	probably damaging	1.00
R5511:Flnc	UTSW	6	29,458,898 (GRCm38)	missense	probably damaging	1.00
R5539:Flnc	UTSW	6	29,446,230 (GRCm38)	missense	probably damaging	1.00
R5549:Flnc	UTSW	6	29,453,691 (GRCm38)	missense	probably damaging	1.00
R5567:Flnc	UTSW	6	29,444,045 (GRCm38)	nonsense	probably null
R5584:Flnc	UTSW	6	29,446,628 (GRCm38)	missense	probably damaging	0.98
R5689:Flnc	UTSW	6	29,441,592 (GRCm38)	missense	probably benign	0.03
R5753:Flnc	UTSW	6	29,433,489 (GRCm38)	missense	probably benign
R5786:Flnc	UTSW	6	29,459,537 (GRCm38)	nonsense	probably null
R5822:Flnc	UTSW	6	29,459,430 (GRCm38)	missense	probably damaging	0.98
R5823:Flnc	UTSW	6	29,461,202 (GRCm38)	missense	probably damaging	0.99
R5933:Flnc	UTSW	6	29,441,106 (GRCm38)	missense	probably damaging	0.99
R6043:Flnc	UTSW	6	29,446,608 (GRCm38)	missense	probably damaging	1.00
R6320:Flnc	UTSW	6	29,459,063 (GRCm38)	missense	probably damaging	1.00
R6337:Flnc	UTSW	6	29,454,319 (GRCm38)	missense	probably damaging	0.99
R6399:Flnc	UTSW	6	29,458,883 (GRCm38)	missense	probably damaging	1.00
R6423:Flnc	UTSW	6	29,445,156 (GRCm38)	splice site	probably null
R6540:Flnc	UTSW	6	29,446,377 (GRCm38)	missense	possibly damaging	0.96
R6547:Flnc	UTSW	6	29,448,608 (GRCm38)	missense	probably damaging	0.98
R6717:Flnc	UTSW	6	29,450,902 (GRCm38)	small deletion	probably benign
R7193:Flnc	UTSW	6	29,450,871 (GRCm38)	missense	probably damaging	1.00
R7255:Flnc	UTSW	6	29,445,766 (GRCm38)	missense	probably damaging	1.00
R7303:Flnc	UTSW	6	29,460,850 (GRCm38)	missense	probably benign	0.31
R7413:Flnc	UTSW	6	29,452,259 (GRCm38)	missense	probably damaging	1.00
R7422:Flnc	UTSW	6	29,455,471 (GRCm38)	missense	probably damaging	1.00
R7559:Flnc	UTSW	6	29,459,010 (GRCm38)	missense	probably damaging	1.00
R7632:Flnc	UTSW	6	29,446,985 (GRCm38)	missense	probably damaging	0.98
R7651:Flnc	UTSW	6	29,444,050 (GRCm38)	missense	probably benign	0.08
R7679:Flnc	UTSW	6	29,456,790 (GRCm38)	missense	probably benign	0.00
R7697:Flnc	UTSW	6	29,456,517 (GRCm38)	missense	probably damaging	0.98
R7788:Flnc	UTSW	6	29,456,444 (GRCm38)	missense	possibly damaging	0.67
R7852:Flnc	UTSW	6	29,440,898 (GRCm38)	missense	probably damaging	1.00
R7870:Flnc	UTSW	6	29,454,307 (GRCm38)	missense	probably damaging	1.00
R7873:Flnc	UTSW	6	29,456,991 (GRCm38)	missense	possibly damaging	0.88
R7921:Flnc	UTSW	6	29,447,770 (GRCm38)	missense	possibly damaging	0.58
R7950:Flnc	UTSW	6	29,456,382 (GRCm38)	missense	possibly damaging	0.61
R7953:Flnc	UTSW	6	29,447,829 (GRCm38)	missense	probably damaging	0.99
R7970:Flnc	UTSW	6	29,447,526 (GRCm38)	missense	possibly damaging	0.96
R8071:Flnc	UTSW	6	29,457,446 (GRCm38)	missense	probably damaging	1.00
R8143:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign	0.20
R8166:Flnc	UTSW	6	29,433,732 (GRCm38)	missense	probably damaging	0.99
R8167:Flnc	UTSW	6	29,455,922 (GRCm38)	missense	probably damaging	0.98
R8306:Flnc	UTSW	6	29,449,370 (GRCm38)	missense	probably benign	0.05
R8428:Flnc	UTSW	6	29,450,850 (GRCm38)	missense	probably benign	0.36
R8466:Flnc	UTSW	6	29,438,622 (GRCm38)	missense	probably damaging	0.98
R8671:Flnc	UTSW	6	29,443,502 (GRCm38)	critical splice donor site	probably null
R8885:Flnc	UTSW	6	29,455,411 (GRCm38)	missense	probably damaging	0.96
R8922:Flnc	UTSW	6	29,456,836 (GRCm38)	missense	probably damaging	0.99
R8923:Flnc	UTSW	6	29,452,237 (GRCm38)	missense	probably damaging	1.00
R8985:Flnc	UTSW	6	29,440,500 (GRCm38)	missense	probably benign	0.37
R9075:Flnc	UTSW	6	29,447,647 (GRCm38)	missense	probably damaging	0.96
R9098:Flnc	UTSW	6	29,455,519 (GRCm38)	nonsense	probably null
R9162:Flnc	UTSW	6	29,455,861 (GRCm38)	missense	probably damaging	1.00
R9199:Flnc	UTSW	6	29,441,491 (GRCm38)	missense	probably benign	0.31
R9204:Flnc	UTSW	6	29,452,354 (GRCm38)	missense	possibly damaging	0.93
R9273:Flnc	UTSW	6	29,447,816 (GRCm38)	missense	probably benign	0.08
R9411:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign
R9412:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign
R9413:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign
R9451:Flnc	UTSW	6	29,445,463 (GRCm38)	missense	probably damaging	0.98
R9524:Flnc	UTSW	6	29,461,110 (GRCm38)	missense	probably damaging	1.00
R9575:Flnc	UTSW	6	29,454,400 (GRCm38)	missense	probably damaging	0.98
R9582:Flnc	UTSW	6	29,460,737 (GRCm38)	missense	probably damaging	0.99
R9595:Flnc	UTSW	6	29,433,721 (GRCm38)	missense	probably benign	0.05
R9664:Flnc	UTSW	6	29,457,215 (GRCm38)	missense	probably damaging	1.00
R9665:Flnc	UTSW	6	29,455,448 (GRCm38)	missense	probably damaging	1.00
R9686:Flnc	UTSW	6	29,456,435 (GRCm38)	missense	possibly damaging	0.84
Z1088:Flnc	UTSW	6	29,457,151 (GRCm38)	missense	probably damaging	1.00
Z1177:Flnc	UTSW	6	29,457,130 (GRCm38)	missense	probably damaging	1.00
Z1177:Flnc	UTSW	6	29,447,545 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATCCACTAGAACCAGTTGCC -3'
(R):5'- ATCATGTTGGCTGTGGCAC -3'

Sequencing Primer
(F):5'- TGGGCACAGTTCCAGGAG -3'
(R):5'- TGGCACACACAAGGGACTC -3'

Posted On

2018-10-18