Incidental Mutation 'IGL01160:Olfr67'
ID53642
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr67
Ensembl Gene ENSMUSG00000047535
Gene Nameolfactory receptor 67
SynonymsGA_x6K02T2PBJ9-6515150-6514170, 3'[b]1, MOR31-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01160
Quality Score
Status
Chromosome7
Chromosomal Location103784594-103791821 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 103787636 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Arginine at position 214 (G214R)
Ref Sequence ENSEMBL: ENSMUSP00000138389 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000183254]
Predicted Effect probably damaging
Transcript: ENSMUST00000062377
AA Change: G214R

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000091670
Gene: ENSMUSG00000047535
AA Change: G214R

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 3.7e-114 PFAM
Pfam:7TM_GPCR_Srsx 41 231 5.5e-11 PFAM
Pfam:7tm_1 47 299 1.5e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000183254
AA Change: G214R

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000138389
Gene: ENSMUSG00000047535
AA Change: G214R

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 41 231 5.5e-11 PFAM
Pfam:7tm_1 47 299 2.7e-30 PFAM
Pfam:7tm_4 146 292 1.7e-29 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210016F16Rik A G 13: 58,381,976 V274A probably damaging Het
Atp11a A G 8: 12,844,609 T188A probably damaging Het
Bfsp2 A G 9: 103,480,168 V20A probably benign Het
Btn1a1 G A 13: 23,461,737 T154M possibly damaging Het
Ccdc117 T C 11: 5,531,532 S200G probably benign Het
Col24a1 G A 3: 145,507,713 G1358S probably damaging Het
Crlf2 T C 5: 109,557,570 T40A possibly damaging Het
Cstf2 T A X: 134,060,729 probably benign Het
Dcdc2a A G 13: 25,119,329 D281G probably benign Het
Dmd T C X: 83,924,961 L1855P probably damaging Het
Dnajc5g T C 5: 31,110,185 V112A probably benign Het
Dnmt1 G A 9: 20,917,319 P828S possibly damaging Het
Dock3 A T 9: 106,906,688 S268R probably damaging Het
Dpep2 C T 8: 105,986,444 V440M possibly damaging Het
F8 A T X: 75,288,061 M741K probably damaging Het
Fermt3 C T 19: 7,003,258 probably null Het
Fosb A G 7: 19,307,114 probably null Het
Gm14085 A C 2: 122,524,796 probably null Het
Gm3238 C A 10: 77,770,883 probably benign Het
Hyal5 T A 6: 24,876,481 S118T possibly damaging Het
Igf2r T C 17: 12,704,775 D1140G possibly damaging Het
Ighmbp2 G T 19: 3,276,750 probably benign Het
Irf3 C A 7: 44,998,796 D28E possibly damaging Het
Ly6i A T 15: 74,980,032 I96N possibly damaging Het
Macrod2 T C 2: 140,825,042 probably benign Het
Olfr1222 A T 2: 89,125,728 M1K probably null Het
Olfr124 A G 17: 37,806,050 R302G probably benign Het
Olfr1309 A G 2: 111,983,933 L47P probably damaging Het
Otof A T 5: 30,381,535 M1128K probably benign Het
Parp9 A T 16: 35,947,998 I183F probably damaging Het
Pbsn T C X: 77,842,571 N147S probably benign Het
Pcf11 A G 7: 92,661,686 S365P possibly damaging Het
Pcnx4 T G 12: 72,579,377 V1119G probably damaging Het
Rsf1 C T 7: 97,685,584 T1308M probably damaging Het
Sidt2 A G 9: 45,942,726 L647P probably damaging Het
Slc7a8 A G 14: 54,735,124 V280A probably benign Het
Spg20 T A 3: 55,121,756 F323I probably damaging Het
Supt16 A T 14: 52,183,132 D70E probably benign Het
Tmc4 T C 7: 3,675,518 Y38C possibly damaging Het
Tmco5b G T 2: 113,287,798 probably benign Het
Trav10 G A 14: 53,505,782 probably benign Het
Vmn2r28 A T 7: 5,486,478 M454K probably damaging Het
Vmn2r85 T C 10: 130,418,821 T665A probably benign Het
Yipf7 T C 5: 69,519,317 I160V probably benign Het
Zc3h18 T C 8: 122,408,250 probably benign Het
Zfp429 G A 13: 67,391,013 S91L probably damaging Het
Other mutations in Olfr67
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01352:Olfr67 APN 7 103788078 nonsense probably null 0.00
IGL02318:Olfr67 APN 7 103788268 missense probably benign
R0413:Olfr67 UTSW 7 103788155 missense probably damaging 1.00
R0964:Olfr67 UTSW 7 103787397 missense probably benign 0.18
R2092:Olfr67 UTSW 7 103788072 missense possibly damaging 0.50
R3963:Olfr67 UTSW 7 103788034 missense probably benign 0.02
R4299:Olfr67 UTSW 7 103787995 missense probably benign 0.38
R4799:Olfr67 UTSW 7 103787481 missense possibly damaging 0.49
R5410:Olfr67 UTSW 7 103787374 missense probably damaging 0.97
R5959:Olfr67 UTSW 7 103787516 missense probably damaging 0.99
R6084:Olfr67 UTSW 7 103787955 missense probably benign 0.11
R6336:Olfr67 UTSW 7 103788245 missense possibly damaging 0.86
R7077:Olfr67 UTSW 7 103787386 missense probably damaging 0.99
R7453:Olfr67 UTSW 7 103787672 missense possibly damaging 0.90
Z1088:Olfr67 UTSW 7 103787365 missense probably damaging 0.99
Z1176:Olfr67 UTSW 7 103787453 missense probably benign 0.38
Posted On2013-06-28