Mutagenetix > Incidental Mutation

Incidental Mutation 'R6876:Vmn2r93'

536435

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r93

Ensembl Gene

ENSMUSG00000079698

Gene Name

vomeronasal 2, receptor 93

Synonyms

EG627132

MMRRC Submission

044972-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R6876 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

18518543-18546703 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18525450 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 369 (H369Q)

Ref Sequence

ENSEMBL: ENSMUSP00000155900 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079206] [ENSMUST00000231879] [ENSMUST00000231938]

AlphaFold

L7N1Z9

Predicted Effect

probably benign
Transcript: ENSMUST00000079206
AA Change: H369Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000078200
Gene: ENSMUSG00000079698
AA Change: H369Q

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	453	5.9e-40	PFAM
Pfam:NCD3G	509	562	2.6e-21	PFAM
Pfam:7tm_3	594	830	1.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231879
AA Change: H369Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000231938
AA Change: H369Q

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	T	C	5: 77,044,288 (GRCm39)	T201A	probably damaging	Het
Abca12	T	A	1: 71,302,667 (GRCm39)	D2184V	probably damaging	Het
Abcf1	C	T	17: 36,270,136 (GRCm39)	D641N	probably benign	Het
Adgrv1	C	A	13: 81,303,273 (GRCm39)		probably null	Het
Aftph	T	C	11: 20,659,744 (GRCm39)	E693G	probably damaging	Het
Ahnak	A	G	19: 8,991,484 (GRCm39)	D4256G	probably damaging	Het
Arv1	A	G	8: 125,457,651 (GRCm39)	K185R	probably damaging	Het
Ces4a	T	A	8: 105,871,624 (GRCm39)	V258D	possibly damaging	Het
Col6a5	T	C	9: 105,814,506 (GRCm39)	D502G	unknown	Het
Diaph1	A	T	18: 38,029,426 (GRCm39)	H335Q	unknown	Het
Dtna	G	A	18: 23,744,167 (GRCm39)	V404I	probably benign	Het
Ephb1	T	C	9: 101,861,319 (GRCm39)	D615G	probably damaging	Het
Gimap3	A	T	6: 48,742,855 (GRCm39)	I25N	probably damaging	Het
Hao1	A	G	2: 134,343,069 (GRCm39)	V274A	probably benign	Het
Hirip3	T	C	7: 126,463,321 (GRCm39)	S426P	probably damaging	Het
Igkv4-69	T	C	6: 69,260,818 (GRCm39)	D103G	probably damaging	Het
Kdm8	T	C	7: 125,051,830 (GRCm39)	V141A	probably benign	Het
Mink1	G	T	11: 70,498,261 (GRCm39)	A553S	probably benign	Het
Mpl	T	A	4: 118,314,317 (GRCm39)	Y60F	probably damaging	Het
Muc5ac	C	T	7: 141,363,481 (GRCm39)		probably benign	Het
Myo5a	C	A	9: 75,067,772 (GRCm39)	R609S	probably benign	Het
Myo5b	A	T	18: 74,841,026 (GRCm39)	H969L	probably benign	Het
Or1n2	T	A	2: 36,797,834 (GRCm39)	I292N	probably damaging	Het
Or2h2c	G	C	17: 37,422,098 (GRCm39)	Q259E	probably damaging	Het
Or2y16	T	C	11: 49,335,068 (GRCm39)	L130P	probably damaging	Het
Peg10	T	TCCA	6: 4,756,451 (GRCm39)		probably benign	Het
Prodh2	T	A	7: 30,205,925 (GRCm39)	W207R	probably damaging	Het
Qng1	T	C	13: 58,532,910 (GRCm39)	D20G	probably damaging	Het
Rfx6	A	G	10: 51,596,087 (GRCm39)	K457E	probably damaging	Het
Sim1	A	G	10: 50,859,791 (GRCm39)	E551G	possibly damaging	Het
Soat2	T	C	15: 102,069,049 (GRCm39)	F358S	probably damaging	Het
Tes3-ps	A	G	13: 49,647,195 (GRCm39)	K24E	probably benign	Het
Txndc16	A	G	14: 45,400,497 (GRCm39)	F335L	possibly damaging	Het
Unc45b	T	C	11: 82,813,738 (GRCm39)	Y382H	probably benign	Het
Vmn2r60	A	G	7: 41,785,087 (GRCm39)	T100A	probably null	Het
Yy1	A	G	12: 108,772,518 (GRCm39)	I265V	probably benign	Het
Zfp54	A	T	17: 21,654,239 (GRCm39)	K244N	probably damaging	Het

Other mutations in Vmn2r93

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00743:Vmn2r93	APN	17	18,546,504 (GRCm39)	missense	probably damaging	1.00
IGL01326:Vmn2r93	APN	17	18,536,906 (GRCm39)	missense	possibly damaging	0.92
IGL01328:Vmn2r93	APN	17	18,545,819 (GRCm39)	missense	probably benign	0.00
IGL01360:Vmn2r93	APN	17	18,525,510 (GRCm39)	missense	possibly damaging	0.71
IGL01382:Vmn2r93	APN	17	18,533,578 (GRCm39)	nonsense	probably null
IGL01463:Vmn2r93	APN	17	18,525,150 (GRCm39)	missense	probably damaging	1.00
IGL02057:Vmn2r93	APN	17	18,546,032 (GRCm39)	missense	probably damaging	1.00
IGL02257:Vmn2r93	APN	17	18,545,770 (GRCm39)	unclassified	probably benign
IGL02686:Vmn2r93	APN	17	18,533,526 (GRCm39)	missense	possibly damaging	0.89
IGL02720:Vmn2r93	APN	17	18,525,296 (GRCm39)	missense	probably damaging	1.00
IGL03328:Vmn2r93	APN	17	18,525,220 (GRCm39)	missense	probably damaging	1.00
PIT4576001:Vmn2r93	UTSW	17	18,533,473 (GRCm39)	missense	probably benign
R0067:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R0067:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R0240:Vmn2r93	UTSW	17	18,525,061 (GRCm39)	missense	probably benign	0.00
R0240:Vmn2r93	UTSW	17	18,525,061 (GRCm39)	missense	probably benign	0.00
R0488:Vmn2r93	UTSW	17	18,546,311 (GRCm39)	missense	probably damaging	1.00
R0667:Vmn2r93	UTSW	17	18,546,503 (GRCm39)	missense	probably damaging	1.00
R0668:Vmn2r93	UTSW	17	18,518,667 (GRCm39)	missense	probably benign	0.00
R0850:Vmn2r93	UTSW	17	18,525,279 (GRCm39)	missense	possibly damaging	0.93
R0924:Vmn2r93	UTSW	17	18,524,443 (GRCm39)	missense	probably benign
R0947:Vmn2r93	UTSW	17	18,524,343 (GRCm39)	missense	probably benign	0.06
R1124:Vmn2r93	UTSW	17	18,518,710 (GRCm39)	missense	probably benign	0.00
R1584:Vmn2r93	UTSW	17	18,525,413 (GRCm39)	missense	possibly damaging	0.84
R1943:Vmn2r93	UTSW	17	18,546,063 (GRCm39)	missense	probably benign	0.04
R2012:Vmn2r93	UTSW	17	18,536,840 (GRCm39)	missense	probably benign	0.01
R2018:Vmn2r93	UTSW	17	18,546,324 (GRCm39)	missense	probably damaging	1.00
R2196:Vmn2r93	UTSW	17	18,525,428 (GRCm39)	missense	probably damaging	1.00
R2373:Vmn2r93	UTSW	17	18,518,665 (GRCm39)	missense	probably benign
R2864:Vmn2r93	UTSW	17	18,546,323 (GRCm39)	missense	probably damaging	1.00
R4276:Vmn2r93	UTSW	17	18,525,092 (GRCm39)	missense	possibly damaging	0.47
R4446:Vmn2r93	UTSW	17	18,524,312 (GRCm39)	missense	possibly damaging	0.93
R4537:Vmn2r93	UTSW	17	18,525,194 (GRCm39)	missense	possibly damaging	0.86
R4674:Vmn2r93	UTSW	17	18,525,255 (GRCm39)	missense	probably benign	0.34
R4726:Vmn2r93	UTSW	17	18,536,960 (GRCm39)	missense	probably damaging	1.00
R4936:Vmn2r93	UTSW	17	18,524,327 (GRCm39)	missense	possibly damaging	0.95
R4984:Vmn2r93	UTSW	17	18,533,389 (GRCm39)	splice site	probably null
R5111:Vmn2r93	UTSW	17	18,546,326 (GRCm39)	missense	probably damaging	0.99
R5749:Vmn2r93	UTSW	17	18,518,546 (GRCm39)	missense	probably benign	0.06
R5918:Vmn2r93	UTSW	17	18,546,030 (GRCm39)	missense	probably damaging	1.00
R5921:Vmn2r93	UTSW	17	18,546,030 (GRCm39)	missense	probably damaging	1.00
R6091:Vmn2r93	UTSW	17	18,545,958 (GRCm39)	missense	probably benign	0.06
R6283:Vmn2r93	UTSW	17	18,524,366 (GRCm39)	missense	probably benign	0.02
R6680:Vmn2r93	UTSW	17	18,536,920 (GRCm39)	nonsense	probably null
R6963:Vmn2r93	UTSW	17	18,536,849 (GRCm39)	missense	probably damaging	1.00
R6996:Vmn2r93	UTSW	17	18,524,903 (GRCm39)	missense	probably damaging	1.00
R7027:Vmn2r93	UTSW	17	18,533,548 (GRCm39)	missense	probably benign	0.01
R7034:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7036:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7246:Vmn2r93	UTSW	17	18,546,012 (GRCm39)	missense	possibly damaging	0.89
R7258:Vmn2r93	UTSW	17	18,525,403 (GRCm39)	missense	probably benign	0.32
R7323:Vmn2r93	UTSW	17	18,533,497 (GRCm39)	nonsense	probably null
R7325:Vmn2r93	UTSW	17	18,524,249 (GRCm39)	missense	probably benign	0.01
R7390:Vmn2r93	UTSW	17	18,525,329 (GRCm39)	missense	probably damaging	1.00
R7427:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7428:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7448:Vmn2r93	UTSW	17	18,546,248 (GRCm39)	missense	probably benign	0.19
R7453:Vmn2r93	UTSW	17	18,533,580 (GRCm39)	missense	probably benign	0.10
R7562:Vmn2r93	UTSW	17	18,518,731 (GRCm39)	missense	probably benign	0.01
R7662:Vmn2r93	UTSW	17	18,525,631 (GRCm39)	missense	probably benign	0.00
R7682:Vmn2r93	UTSW	17	18,525,583 (GRCm39)	missense	probably benign	0.03
R7704:Vmn2r93	UTSW	17	18,536,910 (GRCm39)	missense	probably benign	0.01
R7772:Vmn2r93	UTSW	17	18,533,482 (GRCm39)	missense	probably damaging	0.99
R7957:Vmn2r93	UTSW	17	18,545,954 (GRCm39)	nonsense	probably null
R8276:Vmn2r93	UTSW	17	18,525,649 (GRCm39)	critical splice donor site	probably null
R8290:Vmn2r93	UTSW	17	18,524,291 (GRCm39)	missense	probably damaging	1.00
R8362:Vmn2r93	UTSW	17	18,546,353 (GRCm39)	missense	probably benign	0.02
R8376:Vmn2r93	UTSW	17	18,525,230 (GRCm39)	missense	probably damaging	1.00
R8870:Vmn2r93	UTSW	17	18,525,320 (GRCm39)	missense	possibly damaging	0.91
R8925:Vmn2r93	UTSW	17	18,546,500 (GRCm39)	missense	probably damaging	0.99
R8927:Vmn2r93	UTSW	17	18,546,500 (GRCm39)	missense	probably damaging	0.99
R8954:Vmn2r93	UTSW	17	18,546,252 (GRCm39)	missense	probably damaging	0.99
R9038:Vmn2r93	UTSW	17	18,524,471 (GRCm39)	missense	probably benign
R9131:Vmn2r93	UTSW	17	18,546,143 (GRCm39)	missense	probably damaging	0.99
R9205:Vmn2r93	UTSW	17	18,524,281 (GRCm39)	missense	probably damaging	1.00
R9530:Vmn2r93	UTSW	17	18,518,562 (GRCm39)	missense	probably damaging	0.96
Z1088:Vmn2r93	UTSW	17	18,546,665 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r93	UTSW	17	18,525,600 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGTCATGAACACTGAACACCATG -3'
(R):5'- TGTACCTGCCATGGAAAGAAC -3'

Sequencing Primer
(F):5'- GACTCATTCCATGGAAGC -3'
(R):5'- TGCCATGGAAAGAACACCATC -3'

Posted On

2018-10-18