Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01161:Ceacam11'

53647

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ceacam11

Ensembl Gene

ENSMUSG00000030368

Gene Name

CEA cell adhesion molecule 11

Synonyms

Ceacam11-C1, Ceacam11-C3, Ceacam11-C4, 1600015D01Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL01161

Quality Score

Status

Chromosome

Chromosomal Location

17706092-17712481 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 17712435 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 295 (I295F)

Ref Sequence

ENSEMBL: ENSMUSP00000092393 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094799]

AlphaFold

Q9D0Z8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094799
AA Change: I295F

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000092393
Gene: ENSMUSG00000030368
AA Change: I295F

Domain	Start	End	E-Value	Type
IG_like	40	141	8.06e0	SMART
IG_like	160	261	8.5e0	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb2	T	A	2: 103,535,463 (GRCm39)	D543E	probably benign	Het
Acad9	A	C	3: 36,144,274 (GRCm39)	N583T	possibly damaging	Het
Arhgap5	G	A	12: 52,563,643 (GRCm39)	V205M	probably damaging	Het
Arid1b	G	A	17: 5,392,674 (GRCm39)	R2068Q	probably damaging	Het
Bex3	T	C	X: 135,172,218 (GRCm39)	F60S	probably damaging	Het
Casd1	C	T	6: 4,619,833 (GRCm39)	P193S	possibly damaging	Het
Ceacam3	T	A	7: 16,885,782 (GRCm39)	N128K	probably benign	Het
Cyp1a2	C	T	9: 57,587,176 (GRCm39)	E372K	probably damaging	Het
Ddb1	T	G	19: 10,583,071 (GRCm39)	M1R	probably null	Het
Ecel1	T	C	1: 87,080,915 (GRCm39)	D329G	possibly damaging	Het
Fat2	T	C	11: 55,175,017 (GRCm39)	N1899D	probably benign	Het
Gli3	A	G	13: 15,722,983 (GRCm39)		probably null	Het
Gm20507	A	T	17: 33,863,727 (GRCm39)		probably benign	Het
Gml	T	G	15: 74,685,688 (GRCm39)	Y99S	probably damaging	Het
Gpr119	G	T	X: 47,762,125 (GRCm39)		probably benign	Het
Hcn1	T	C	13: 117,793,458 (GRCm39)	Y237H	unknown	Het
Hook2	G	A	8: 85,721,560 (GRCm39)	V273I	probably benign	Het
Il12rb2	T	C	6: 67,338,849 (GRCm39)		probably benign	Het
Kdm2a	A	G	19: 4,369,279 (GRCm39)	F1112S	probably benign	Het
Lpl	A	T	8: 69,345,277 (GRCm39)	K94*	probably null	Het
Lrrc8a	T	A	2: 30,145,822 (GRCm39)	L212Q	probably damaging	Het
Me2	A	T	18: 73,903,887 (GRCm39)		probably benign	Het
Mmp11	A	T	10: 75,762,655 (GRCm39)	M266K	probably benign	Het
Mprip	T	A	11: 59,622,399 (GRCm39)	V162E	possibly damaging	Het
Nsf	C	T	11: 103,752,711 (GRCm39)		probably benign	Het
Or56b2	T	C	7: 104,337,588 (GRCm39)	V122A	probably benign	Het
Pcif1	T	A	2: 164,727,708 (GRCm39)	L167H	probably damaging	Het
Reps1	T	C	10: 17,969,643 (GRCm39)	S249P	probably damaging	Het
Sdf4	T	A	4: 156,093,763 (GRCm39)	M299K	probably benign	Het
Slc30a7	A	G	3: 115,747,759 (GRCm39)	V344A	possibly damaging	Het
Svep1	G	A	4: 58,146,569 (GRCm39)	P358S	probably damaging	Het
Syt9	G	T	7: 107,024,356 (GRCm39)	R83L	probably damaging	Het
Tbc1d15	T	C	10: 115,038,435 (GRCm39)	I593V	probably benign	Het
Trio	T	A	15: 27,749,867 (GRCm39)	N1134I	probably damaging	Het
Trpv3	A	G	11: 73,187,544 (GRCm39)		probably benign	Het
Ugp2	T	A	11: 21,273,273 (GRCm39)	I449L	possibly damaging	Het
Usp24	C	A	4: 106,294,041 (GRCm39)	H2595N	probably benign	Het
Vat1l	A	G	8: 115,096,629 (GRCm39)	N370S	possibly damaging	Het
Wwc1	C	A	11: 35,758,103 (GRCm39)	D748Y	probably damaging	Het
Zfyve9	G	A	4: 108,538,261 (GRCm39)	H1002Y	probably damaging	Het

Other mutations in Ceacam11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00844:Ceacam11	APN	7	17,707,595 (GRCm39)	missense	possibly damaging	0.82
IGL01744:Ceacam11	APN	7	17,707,323 (GRCm39)	missense	possibly damaging	0.95
IGL02052:Ceacam11	APN	7	17,707,548 (GRCm39)	missense	probably benign	0.09
IGL02337:Ceacam11	APN	7	17,707,550 (GRCm39)	missense	probably benign	0.09
IGL03079:Ceacam11	APN	7	17,712,361 (GRCm39)	missense	probably benign	0.02
R1902:Ceacam11	UTSW	7	17,709,252 (GRCm39)	missense	probably benign	0.05
R2204:Ceacam11	UTSW	7	17,709,273 (GRCm39)	missense	possibly damaging	0.92
R2851:Ceacam11	UTSW	7	17,712,451 (GRCm39)	missense	probably benign	0.01
R3237:Ceacam11	UTSW	7	17,707,379 (GRCm39)	missense	probably benign	0.02
R4786:Ceacam11	UTSW	7	17,706,239 (GRCm39)	critical splice donor site	probably null
R8097:Ceacam11	UTSW	7	17,709,455 (GRCm39)	nonsense	probably null
R8109:Ceacam11	UTSW	7	17,709,243 (GRCm39)	missense	probably benign	0.01
R8476:Ceacam11	UTSW	7	17,707,618 (GRCm39)	missense	probably benign	0.03
R8878:Ceacam11	UTSW	7	17,709,536 (GRCm39)	missense	probably benign	0.01
R9492:Ceacam11	UTSW	7	17,709,468 (GRCm39)	missense	probably benign	0.00

Posted On

2013-06-28