Incidental Mutation 'R6881:Or10ak16'
ID 536655
Institutional Source Beutler Lab
Gene Symbol Or10ak16
Ensembl Gene ENSMUSG00000073768
Gene Name olfactory receptor family 10 subfamily AK member 16
Synonyms Olfr1330, MOR259-8, GA_x6K02T2QD9B-18644371-18643424
MMRRC Submission 045030-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R6881 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118750282-118751229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118750304 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 8 (N8S)
Ref Sequence ENSEMBL: ENSMUSP00000101968 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094830] [ENSMUST00000105035] [ENSMUST00000106361]
AlphaFold Q8VEY6
Predicted Effect probably damaging
Transcript: ENSMUST00000094830
AA Change: N8S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092425
Gene: ENSMUSG00000073768
AA Change: N8S

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 1.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 1.4e-6 PFAM
Pfam:7tm_1 44 293 1.6e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000105035
AA Change: N8S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100652
Gene: ENSMUSG00000073768
AA Change: N8S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 307 6.4e-8 PFAM
Pfam:7tm_1 44 293 2.9e-31 PFAM
Pfam:7tm_4 142 286 6.7e-46 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106361
AA Change: N8S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101968
Gene: ENSMUSG00000073768
AA Change: N8S

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.1e-56 PFAM
Pfam:7tm_1 43 292 3.9e-25 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406C07Rik A C 9: 15,202,061 (GRCm39) C187G possibly damaging Het
Abhd16a C T 17: 35,315,577 (GRCm39) T208I probably benign Het
Ahcyl1 A T 3: 107,575,425 (GRCm39) H425Q probably damaging Het
Ankrd22 T A 19: 34,126,782 (GRCm39) N16I probably damaging Het
Cc2d2b A G 19: 40,813,483 (GRCm39) E1321G probably damaging Het
Ccdc7b A G 8: 129,799,028 (GRCm39) E35G probably damaging Het
Chsy3 A G 18: 59,312,480 (GRCm39) I318V probably damaging Het
Clrn2 G A 5: 45,611,164 (GRCm39) W4* probably null Het
Cmip T C 8: 118,163,334 (GRCm39) I355T possibly damaging Het
Cmya5 C T 13: 93,226,800 (GRCm39) V2763M probably damaging Het
Cnnm2 T C 19: 46,865,658 (GRCm39) S749P probably damaging Het
Cyp1a1 G T 9: 57,608,002 (GRCm39) R210L possibly damaging Het
Dmxl1 G A 18: 50,068,372 (GRCm39) S2715N probably benign Het
Dync1h1 T C 12: 110,590,995 (GRCm39) L1021P probably damaging Het
Ecm2 C T 13: 49,683,818 (GRCm39) Q599* probably null Het
Galnt11 G T 5: 25,455,097 (GRCm39) K144N possibly damaging Het
Gm45861 A G 8: 28,025,279 (GRCm39) probably null Het
Kcnk18 T A 19: 59,208,390 (GRCm39) D75E probably benign Het
Kcnk2 C T 1: 188,942,187 (GRCm39) V346M probably benign Het
Klhl33 T A 14: 51,128,929 (GRCm39) M767L probably benign Het
Knl1 T C 2: 118,925,665 (GRCm39) I1898T possibly damaging Het
Lama5 G A 2: 179,833,455 (GRCm39) P1519L probably damaging Het
Lamp3 T C 16: 19,518,368 (GRCm39) T290A probably benign Het
Larp1 T A 11: 57,940,849 (GRCm39) D658E probably damaging Het
Macf1 T A 4: 123,326,246 (GRCm39) I3521F probably damaging Het
Med12l T C 3: 59,174,586 (GRCm39) S1835P probably benign Het
Mef2c C A 13: 83,741,061 (GRCm39) N73K probably damaging Het
Mtmr3 T C 11: 4,439,725 (GRCm39) S572G probably benign Het
Neto2 A T 8: 86,367,185 (GRCm39) S520T probably damaging Het
Or1o4 A G 17: 37,591,200 (GRCm39) L37S probably benign Het
Or4c110 A T 2: 88,832,281 (GRCm39) M117K probably damaging Het
P3h2 G A 16: 25,811,495 (GRCm39) R243C probably damaging Het
Pld1 T C 3: 28,132,563 (GRCm39) S584P possibly damaging Het
Prkcz T C 4: 155,353,513 (GRCm39) N278S possibly damaging Het
Radil A G 5: 142,472,672 (GRCm39) S913P probably benign Het
Retreg2 A C 1: 75,123,083 (GRCm39) Q337P probably damaging Het
Sh3gl3 A G 7: 81,956,178 (GRCm39) E305G possibly damaging Het
Shank1 G T 7: 44,001,217 (GRCm39) D979Y unknown Het
Slc35a5 A T 16: 44,964,443 (GRCm39) N263K possibly damaging Het
Slc4a7 A T 14: 14,737,452 (GRCm38) M127L probably benign Het
Slc8a2 G A 7: 15,891,282 (GRCm39) G774E probably damaging Het
Smim45 C A 15: 82,143,786 (GRCm39) H3N possibly damaging Het
Snap91 A G 9: 86,655,646 (GRCm39) S847P possibly damaging Het
Stoml1 T C 9: 58,168,177 (GRCm39) L296P probably damaging Het
Tap1 G T 17: 34,407,008 (GRCm39) G52V probably damaging Het
Tent4b T C 8: 88,977,416 (GRCm39) V363A possibly damaging Het
Tnfrsf11b T C 15: 54,117,539 (GRCm39) R239G probably benign Het
Ttn T C 2: 76,536,846 (GRCm39) Y34993C probably damaging Het
Uchl1 T C 5: 66,841,065 (GRCm39) F165L probably damaging Het
Xrcc1 C T 7: 24,246,776 (GRCm39) Q15* probably null Het
Zkscan7 C G 9: 122,717,766 (GRCm39) Q54E possibly damaging Het
Other mutations in Or10ak16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01385:Or10ak16 APN 4 118,750,748 (GRCm39) missense probably benign 0.00
IGL01642:Or10ak16 APN 4 118,750,658 (GRCm39) missense probably damaging 1.00
R0402:Or10ak16 UTSW 4 118,750,426 (GRCm39) missense possibly damaging 0.95
R0418:Or10ak16 UTSW 4 118,750,448 (GRCm39) missense possibly damaging 0.51
R0646:Or10ak16 UTSW 4 118,750,687 (GRCm39) missense probably damaging 0.96
R1075:Or10ak16 UTSW 4 118,750,402 (GRCm39) missense probably damaging 1.00
R1743:Or10ak16 UTSW 4 118,750,723 (GRCm39) missense probably benign
R1950:Or10ak16 UTSW 4 118,750,537 (GRCm39) missense probably benign 0.22
R2265:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2268:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2269:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R4648:Or10ak16 UTSW 4 118,751,147 (GRCm39) missense possibly damaging 0.84
R5635:Or10ak16 UTSW 4 118,750,832 (GRCm39) missense probably benign 0.31
R7351:Or10ak16 UTSW 4 118,751,033 (GRCm39) missense probably benign 0.05
R7412:Or10ak16 UTSW 4 118,750,327 (GRCm39) missense possibly damaging 0.83
R8402:Or10ak16 UTSW 4 118,750,716 (GRCm39) missense probably benign 0.01
R9355:Or10ak16 UTSW 4 118,750,784 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGATGAATCAAGATCCTGAGCC -3'
(R):5'- AGTACATGGGAGTGTGCAGC -3'

Sequencing Primer
(F):5'- TCAAGATCCTGAGCCATGTG -3'
(R):5'- AGCTGTGTGTCCAGGCAGAC -3'
Posted On 2018-10-18