Mutagenetix > Incidental Mutation

Incidental Mutation 'R6882:Tmprss11b'

536720

Institutional Source

Beutler Lab

Gene Symbol

Tmprss11b

Ensembl Gene

ENSMUSG00000035861

Gene Name

transmembrane protease, serine 11B

Synonyms

Tmprss11bnl, 9930019B18Rik

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6882 (G1)

Quality Score

133.008

Status

Validated

Chromosome

Chromosomal Location

86657631-86676362 bp(-) (GRCm38)

Type of Mutation

splice site (124 bp from exon)

DNA Base Change (assembly)

T to A at 86671671 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000042406 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038448]

AlphaFold

Q14C59

Predicted Effect

probably null
Transcript: ENSMUST00000038448

SMART Domains

Protein: ENSMUSP00000042406
Gene: ENSMUSG00000035861

Domain	Start	End	E-Value	Type
transmembrane domain	12	34	N/A	INTRINSIC
Pfam:SEA	46	148	2.3e-26	PFAM
Tryp_SPc	184	410	6.19e-89	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.9%

Validation Efficiency

100% (63/63)

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr10	A	G	12: 70,956,351	E238G	probably benign	Het
Adgrf5	T	A	17: 43,450,380	C989S	probably damaging	Het
Ank2	T	G	3: 126,945,757		probably benign	Het
C2cd6	T	C	1: 59,066,159	D320G	probably damaging	Het
Cacnb2	T	A	2: 14,824,299	I15N	probably benign	Het
Cage1	T	A	13: 38,022,558	Q437L	probably damaging	Het
Capn15	G	T	17: 25,960,179		probably null	Het
Cbll1	A	G	12: 31,487,485	Y424H	probably damaging	Het
Ccdc166	T	C	15: 75,981,617	H167R	possibly damaging	Het
Ccdc7a	T	C	8: 128,797,328		probably benign	Het
Cdkl4	T	A	17: 80,543,746	T176S	probably damaging	Het
Cnot1	T	C	8: 95,720,426	E2321G	possibly damaging	Het
Col6a5	G	A	9: 105,940,270	Q281*	probably null	Het
Csmd2	A	G	4: 128,449,269	T1485A	probably benign	Het
Dmxl1	A	G	18: 49,843,784		probably null	Het
Dnah3	A	G	7: 119,971,184	I2271T	possibly damaging	Het
Elavl2	A	G	4: 91,308,715	I42T	probably damaging	Het
Epn3	C	T	11: 94,491,360	A568T	probably benign	Het
Etv3	T	C	3: 87,529,270	F111L	probably damaging	Het
Fnip1	A	G	11: 54,509,898	E1041G	probably damaging	Het
Fosl2	T	C	5: 32,152,864	V219A	possibly damaging	Het
Foxj2	T	A	6: 122,828,505		probably null	Het
Gm8947	G	A	1: 151,193,129	A238T	possibly damaging	Het
Golgb1	C	A	16: 36,913,990	Q1200K	probably benign	Het
Igkv4-55	A	G	6: 69,607,305	Y108H	probably damaging	Het
Iglc1	G	A	16: 19,061,849		probably benign	Het
Ints13	G	T	6: 146,563,441	R221S	probably null	Het
Ipo11	T	C	13: 106,900,682		probably null	Het
Kcnn2	A	T	18: 45,559,438	H27L	possibly damaging	Het
Kcns3	C	T	12: 11,092,048	V217M	probably benign	Het
Klra9	A	T	6: 130,179,022	C257S	probably damaging	Het
Lama5	G	A	2: 180,191,662	P1519L	probably damaging	Het
Lmbr1l	A	G	15: 98,907,586	F345L	probably damaging	Het
Lrrc18	A	C	14: 33,008,689	I62L	probably benign	Het
Mr1	A	G	1: 155,132,453	W259R	possibly damaging	Het
Myo15	G	A	11: 60,524,006	R3325H	probably damaging	Het
Nid2	A	G	14: 19,789,707	D788G	probably damaging	Het
Olfr1386	A	T	11: 49,470,463	Y104F	probably benign	Het
Olfr1436	C	A	19: 12,298,570	Q187H	probably damaging	Het
Olfr192	A	T	16: 59,098,627	C122S	unknown	Het
Olfr212	T	C	6: 116,516,434	V219A	probably benign	Het
Pbld1	T	C	10: 63,061,462	L11P	probably benign	Het
Pcnt	T	C	10: 76,427,828	E434G	probably benign	Het
Prg4	G	A	1: 150,453,495	T174M	probably damaging	Het
Prkdc	G	A	16: 15,783,263		probably null	Het
Prkdc	T	A	16: 15,808,156	S3349T	probably benign	Het
Prpf38a	C	A	4: 108,570,168	E199D	probably benign	Het
Prrc2c	TTGCTGCTGCTGCTGCTGCTGCTGCTGC	TTGCTGCTGCTGCTGCTGCTGCTGC	1: 162,709,061		probably benign	Het
Rhbg	T	A	3: 88,245,220	H339L	probably damaging	Het
Rnf183	A	G	4: 62,428,024	I179T	probably benign	Het
Sh3bp5l	G	T	11: 58,331,699	A7S	probably benign	Het
Slc12a3	T	A	8: 94,365,918	I989N	possibly damaging	Het
Sycp3	C	T	10: 88,472,929	R246*	probably null	Het
Tmx4	T	C	2: 134,644,002	T2A	possibly damaging	Het
Tnfsf10	T	C	3: 27,326,033	L82S	possibly damaging	Het
Tnni3k	T	A	3: 154,957,720	I332F	possibly damaging	Het
Ttn	T	A	2: 76,814,195	T13072S	probably benign	Het
Vmn2r1	A	T	3: 64,090,108	Y395F	possibly damaging	Het
Zbbx	A	G	3: 75,071,712	V476A	probably benign	Het
Zfp341	T	C	2: 154,638,023	C465R	probably damaging	Het
Zfp398	A	G	6: 47,866,082	D224G	probably damaging	Het
Zfp407	G	T	18: 84,343,069		probably null	Het
Zfp52	T	C	17: 21,555,047	M1T	probably null	Het

Other mutations in Tmprss11b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01122:Tmprss11b	APN	5	86663517	missense	probably benign
IGL02340:Tmprss11b	APN	5	86662231	missense	probably benign
IGL02500:Tmprss11b	APN	5	86667323	critical splice donor site	probably null
demolished	UTSW	5	86664314	missense	probably damaging	1.00
R0356:Tmprss11b	UTSW	5	86660467	makesense	probably null
R0506:Tmprss11b	UTSW	5	86661640	missense	probably damaging	1.00
R0528:Tmprss11b	UTSW	5	86671894	missense	probably damaging	1.00
R1424:Tmprss11b	UTSW	5	86664973	missense	probably benign	0.09
R1471:Tmprss11b	UTSW	5	86660496	missense	possibly damaging	0.76
R1554:Tmprss11b	UTSW	5	86661631	missense	probably benign	0.01
R3436:Tmprss11b	UTSW	5	86667584	nonsense	probably null
R3829:Tmprss11b	UTSW	5	86661590	missense	probably damaging	0.98
R4409:Tmprss11b	UTSW	5	86664278	missense	probably benign	0.26
R4495:Tmprss11b	UTSW	5	86665063	nonsense	probably null
R4624:Tmprss11b	UTSW	5	86665036	missense	probably benign	0.04
R4834:Tmprss11b	UTSW	5	86663559	missense	probably damaging	1.00
R5436:Tmprss11b	UTSW	5	86662233	missense	probably benign	0.10
R5812:Tmprss11b	UTSW	5	86665098	missense	possibly damaging	0.67
R6262:Tmprss11b	UTSW	5	86662260	missense	probably benign	0.07
R6893:Tmprss11b	UTSW	5	86663386	critical splice donor site	probably null
R7312:Tmprss11b	UTSW	5	86664314	missense	probably damaging	1.00
R7771:Tmprss11b	UTSW	5	86661695	splice site	probably null
R8101:Tmprss11b	UTSW	5	86664962	critical splice donor site	probably null
X0067:Tmprss11b	UTSW	5	86662200	missense	probably damaging	1.00
Z1177:Tmprss11b	UTSW	5	86660541	missense	probably damaging	1.00
Z1177:Tmprss11b	UTSW	5	86661613	missense	probably benign	0.13

Predicted Primers

PCR Primer
(F):5'- CTAGCTCAAATGTCAATATCCCTTG -3'
(R):5'- TAATCATCCTCTGTGTGCTTGGAG -3'

Sequencing Primer
(F):5'- ATGTCAATATCCCTTGAATTCTCTTC -3'
(R):5'- TTGGAGTGCTGGCAGCC -3'

Posted On

2018-10-18