Incidental Mutation 'R6884:Dcaf13'
ID 536865
Institutional Source Beutler Lab
Gene Symbol Dcaf13
Ensembl Gene ENSMUSG00000022300
Gene Name DDB1 and CUL4 associated factor 13
Synonyms Wdsof1, LOC223499
MMRRC Submission 044979-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.955) question?
Stock # R6884 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 38976300-39010251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38986635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 136 (W136R)
Ref Sequence ENSEMBL: ENSMUSP00000022909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022909]
AlphaFold Q6PAC3
Predicted Effect probably damaging
Transcript: ENSMUST00000022909
AA Change: W136R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: W136R

DomainStartEndE-ValueType
WD40 55 95 5.77e-5 SMART
WD40 98 137 4.38e-5 SMART
WD40 185 225 5.97e-1 SMART
Blast:WD40 228 267 1e-18 BLAST
WD40 271 310 2.69e-5 SMART
WD40 312 353 2.96e-2 SMART
Pfam:Sof1 354 440 7.2e-38 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency
Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aamp A G 1: 74,323,407 (GRCm39) probably benign Het
Abca5 C T 11: 110,220,043 (GRCm39) V8M probably damaging Het
Ahnak2 A T 12: 112,741,863 (GRCm39) D736E possibly damaging Het
Brpf3 A G 17: 29,050,324 (GRCm39) D1072G probably benign Het
Cacna1i C T 15: 80,259,010 (GRCm39) R1240C probably damaging Het
Ccdc40 A T 11: 119,133,565 (GRCm39) E568D possibly damaging Het
Col12a1 C T 9: 79,547,091 (GRCm39) G2247E possibly damaging Het
Dapk3 T A 10: 81,027,588 (GRCm39) probably null Het
Dip2a C A 10: 76,108,366 (GRCm39) probably null Het
Eif3c T C 7: 126,156,051 (GRCm39) D473G probably benign Het
Erich2 G A 2: 70,339,505 (GRCm39) R20H possibly damaging Het
Gcnt7 T C 2: 172,296,125 (GRCm39) N233S probably damaging Het
Gdpd4 G T 7: 97,621,382 (GRCm39) L208F probably damaging Het
Gm10269 T A 18: 20,815,932 (GRCm39) Q30L possibly damaging Het
Gm7298 A T 6: 121,737,480 (GRCm39) I295F possibly damaging Het
Htr7 A G 19: 35,941,779 (GRCm39) probably null Het
Ing1 A G 8: 11,611,916 (GRCm39) Y118C probably damaging Het
Krtap16-1 C T 11: 99,877,284 (GRCm39) W40* probably null Het
Krtap26-1 A T 16: 88,444,467 (GRCm39) D51E probably damaging Het
Lama5 G A 2: 179,833,455 (GRCm39) P1519L probably damaging Het
Lrp1 T A 10: 127,394,986 (GRCm39) Q2513L probably benign Het
Morf4l1 A T 9: 89,976,532 (GRCm39) N265K probably damaging Het
Mpp2 T C 11: 101,952,904 (GRCm39) D299G probably benign Het
Mtcl1 C T 17: 66,745,197 (GRCm39) G55R probably damaging Het
Myb T A 10: 21,028,431 (GRCm39) K144I probably damaging Het
Myo18a T C 11: 77,709,875 (GRCm39) I587T possibly damaging Het
Nr2c2 A G 6: 92,135,374 (GRCm39) S288G probably benign Het
Obscn A G 11: 58,969,128 (GRCm39) Y2700H probably damaging Het
Or2z9 T C 8: 72,854,345 (GRCm39) V247A probably benign Het
Or6c3 T A 10: 129,309,023 (GRCm39) F154Y probably damaging Het
Pde6b A G 5: 108,536,574 (GRCm39) D90G probably damaging Het
Pigo A G 4: 43,022,627 (GRCm39) F315L possibly damaging Het
Prrc2c TTGCTGCTGCTGCTGCTGCTGCTGCTGC TTGCTGCTGCTGCTGCTGCTGCTGC 1: 162,536,630 (GRCm39) probably benign Het
Ret T C 6: 118,132,362 (GRCm39) D1026G probably damaging Het
Rptn A T 3: 93,303,096 (GRCm39) Q143L probably benign Het
Rubcnl A G 14: 75,272,910 (GRCm39) E210G probably benign Het
Serpina1b T A 12: 103,698,712 (GRCm39) T46S probably benign Het
Serpinb9e A T 13: 33,435,609 (GRCm39) H14L probably benign Het
Shoc1 A G 4: 59,059,652 (GRCm39) S1003P possibly damaging Het
Slc25a25 A C 2: 32,310,674 (GRCm39) V168G probably benign Het
Slc35e1 T C 8: 73,238,726 (GRCm39) T261A possibly damaging Het
Spocd1 T C 4: 129,849,197 (GRCm39) probably benign Het
Tmem222 A T 4: 132,995,514 (GRCm39) Y178N probably damaging Het
Top1mt C T 15: 75,535,893 (GRCm39) E470K probably benign Het
Traj42 T C 14: 54,413,290 (GRCm39) probably benign Het
Tshr T C 12: 91,504,876 (GRCm39) Y13H probably damaging Het
Uvssa A G 5: 33,566,461 (GRCm39) probably null Het
Vmn1r28 G A 6: 58,242,633 (GRCm39) V159I probably benign Het
Vmn2r73 T A 7: 85,507,213 (GRCm39) T700S probably benign Het
Other mutations in Dcaf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00787:Dcaf13 APN 15 39,007,027 (GRCm39) nonsense probably null
IGL01081:Dcaf13 APN 15 38,982,201 (GRCm39) missense probably damaging 1.00
IGL01766:Dcaf13 APN 15 38,982,145 (GRCm39) missense probably benign 0.00
IGL02174:Dcaf13 APN 15 39,001,544 (GRCm39) missense probably damaging 1.00
IGL02262:Dcaf13 APN 15 38,982,102 (GRCm39) splice site probably benign
IGL02740:Dcaf13 APN 15 39,008,495 (GRCm39) nonsense probably null
IGL03092:Dcaf13 APN 15 38,991,371 (GRCm39) splice site probably benign
IGL03374:Dcaf13 APN 15 39,008,543 (GRCm39) nonsense probably null
R0590:Dcaf13 UTSW 15 39,008,480 (GRCm39) splice site probably benign
R0594:Dcaf13 UTSW 15 38,986,663 (GRCm39) missense probably benign 0.00
R0711:Dcaf13 UTSW 15 39,001,484 (GRCm39) missense probably damaging 1.00
R1036:Dcaf13 UTSW 15 39,007,113 (GRCm39) missense probably damaging 1.00
R1770:Dcaf13 UTSW 15 38,993,633 (GRCm39) missense probably damaging 1.00
R1826:Dcaf13 UTSW 15 38,982,294 (GRCm39) missense probably damaging 1.00
R1933:Dcaf13 UTSW 15 39,001,483 (GRCm39) missense probably damaging 0.99
R2508:Dcaf13 UTSW 15 39,008,547 (GRCm39) missense probably benign
R4113:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R4595:Dcaf13 UTSW 15 38,982,288 (GRCm39) missense probably damaging 1.00
R4649:Dcaf13 UTSW 15 39,001,637 (GRCm39) missense possibly damaging 0.54
R5431:Dcaf13 UTSW 15 38,986,619 (GRCm39) missense probably benign 0.16
R5454:Dcaf13 UTSW 15 38,987,759 (GRCm39) missense probably benign
R5834:Dcaf13 UTSW 15 39,007,037 (GRCm39) nonsense probably null
R5929:Dcaf13 UTSW 15 39,007,048 (GRCm39) missense possibly damaging 0.89
R5944:Dcaf13 UTSW 15 39,010,072 (GRCm39) missense probably benign
R6319:Dcaf13 UTSW 15 39,007,067 (GRCm39) missense probably benign 0.00
R6394:Dcaf13 UTSW 15 39,007,132 (GRCm39) missense probably benign 0.04
R6664:Dcaf13 UTSW 15 38,982,283 (GRCm39) missense probably damaging 1.00
R7419:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R8750:Dcaf13 UTSW 15 38,982,836 (GRCm39) missense probably damaging 1.00
R8944:Dcaf13 UTSW 15 39,001,612 (GRCm39) missense possibly damaging 0.79
R9294:Dcaf13 UTSW 15 38,993,687 (GRCm39) missense possibly damaging 0.92
R9300:Dcaf13 UTSW 15 39,010,102 (GRCm39) missense probably damaging 1.00
R9663:Dcaf13 UTSW 15 38,982,178 (GRCm39) missense possibly damaging 0.88
R9696:Dcaf13 UTSW 15 39,001,496 (GRCm39) missense possibly damaging 0.80
R9778:Dcaf13 UTSW 15 39,008,586 (GRCm39) missense probably damaging 0.99
Z1088:Dcaf13 UTSW 15 39,008,642 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCTTTACTCATACTGGGGAG -3'
(R):5'- TTAAACCTTGTTTTAGCGGCC -3'

Sequencing Primer
(F):5'- CTTTACTCATACTGGGGAGTTTTG -3'
(R):5'- AACCTTGTTTTAGCGGCCAATTATTC -3'
Posted On 2018-10-18