Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01019:Vmn1r169'

53687

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r169

Ensembl Gene

ENSMUSG00000094602

Gene Name

vomeronasal 1 receptor 169

Synonyms

Gm4232

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL01019

Quality Score

Status

Chromosome

Chromosomal Location

23276610-23277524 bp(+) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

T to G at 23276611 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Arginine at position 1 (M1R)

Ref Sequence

ENSEMBL: ENSMUSP00000154343 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170290] [ENSMUST00000226669] [ENSMUST00000227547] [ENSMUST00000227932] [ENSMUST00000228832]

AlphaFold

L7N275

Predicted Effect

probably null
Transcript: ENSMUST00000170290
AA Change: M1R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000126133
Gene: ENSMUSG00000094602
AA Change: M1R

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	295	4e-14	PFAM
Pfam:V1R	41	295	2.1e-21	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000226669
AA Change: M1R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Predicted Effect

probably null
Transcript: ENSMUST00000227547
AA Change: M1R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Predicted Effect

probably null
Transcript: ENSMUST00000227932
AA Change: M1R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Predicted Effect

probably null
Transcript: ENSMUST00000228832
AA Change: M1R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930022D16Rik	T	C	11: 109,308,737 (GRCm39)		probably benign	Het
Aatk	T	C	11: 119,903,101 (GRCm39)	S375G	probably benign	Het
Abcg8	T	C	17: 84,999,423 (GRCm39)	M173T	probably benign	Het
B3galt2	A	C	1: 143,522,495 (GRCm39)	R210S	probably benign	Het
Bltp1	G	T	3: 37,061,133 (GRCm39)		probably null	Het
Capn5	C	T	7: 97,784,971 (GRCm39)	A168T	probably damaging	Het
Cbx7	C	T	15: 79,814,829 (GRCm39)	G24D	probably damaging	Het
Ccdc7a	A	T	8: 129,788,099 (GRCm39)	S77T	probably benign	Het
Cd200r2	T	A	16: 44,729,832 (GRCm39)		probably benign	Het
Cdh11	T	C	8: 103,406,377 (GRCm39)	H32R	probably benign	Het
Chdh	A	T	14: 29,753,289 (GRCm39)	N66I	probably benign	Het
Clca3a2	G	A	3: 144,519,388 (GRCm39)	Q263*	probably null	Het
Dcc	T	C	18: 71,942,161 (GRCm39)	I319V	probably benign	Het
Depdc5	G	T	5: 33,050,745 (GRCm39)	M170I	probably damaging	Het
Dop1b	T	A	16: 93,607,117 (GRCm39)	L2140Q	probably benign	Het
Frem3	G	A	8: 81,341,763 (GRCm39)	G1352E	probably benign	Het
Fsd1l	T	A	4: 53,694,742 (GRCm39)	C389S	probably damaging	Het
Grin2c	C	T	11: 115,148,936 (GRCm39)	A221T	possibly damaging	Het
Gstz1	C	A	12: 87,210,575 (GRCm39)	P153T	probably damaging	Het
Itgb2	T	C	10: 77,378,237 (GRCm39)	S22P	possibly damaging	Het
Krt87	G	T	15: 101,336,312 (GRCm39)	Q114K	possibly damaging	Het
Krtap5-4	A	C	7: 141,857,647 (GRCm39)	S106R	unknown	Het
Lats1	T	C	10: 7,581,435 (GRCm39)	V740A	probably damaging	Het
Mcm9	C	A	10: 53,506,041 (GRCm39)	G78C	probably damaging	Het
Mn1	G	A	5: 111,569,413 (GRCm39)	E1128K	possibly damaging	Het
Myo1f	G	A	17: 33,811,977 (GRCm39)	R592H	possibly damaging	Het
Nfat5	G	T	8: 108,094,146 (GRCm39)	A277S	probably damaging	Het
Nfkbia	T	A	12: 55,537,327 (GRCm39)	Y254F	probably damaging	Het
Nr3c2	A	T	8: 77,635,843 (GRCm39)	N315Y	probably damaging	Het
Otof	T	C	5: 30,562,560 (GRCm39)	M258V	probably benign	Het
Panx3	C	T	9: 37,572,767 (GRCm39)	C261Y	probably damaging	Het
Pdia2	C	A	17: 26,417,896 (GRCm39)	G38W	probably damaging	Het
Psg19	G	T	7: 18,527,971 (GRCm39)	Y257*	probably null	Het
Ptpre	A	T	7: 135,280,054 (GRCm39)	K586*	probably null	Het
Reps1	A	G	10: 18,000,643 (GRCm39)	R752G	probably damaging	Het
Rpgrip1	T	A	14: 52,368,633 (GRCm39)	D277E	possibly damaging	Het
Rpl21-ps6	A	G	17: 56,222,671 (GRCm39)		noncoding transcript	Het
Serpinf2	T	A	11: 75,327,333 (GRCm39)	E198V	possibly damaging	Het
Sh3tc1	A	G	5: 35,860,719 (GRCm39)	L1046P	probably damaging	Het
Snw1	T	C	12: 87,497,711 (GRCm39)	E426G	probably benign	Het
Sord	T	A	2: 122,094,564 (GRCm39)	N317K	probably benign	Het
Taar3	A	T	10: 23,826,330 (GRCm39)	D292V	probably damaging	Het
Tdrd3	C	A	14: 87,709,618 (GRCm39)	T94K	probably damaging	Het
Ttn	C	A	2: 76,687,165 (GRCm39)	E736*	probably null	Het
Usp32	A	G	11: 84,930,091 (GRCm39)	V562A	probably damaging	Het
Vmn2r3	C	T	3: 64,167,304 (GRCm39)	C609Y	probably damaging	Het
Vmn2r69	T	C	7: 85,055,739 (GRCm39)	T800A	probably benign	Het
Vmn2r72	G	A	7: 85,387,542 (GRCm39)	T674I	probably benign	Het
Zfp160	T	A	17: 21,241,088 (GRCm39)	M52K	possibly damaging	Het
Zfp607a	T	A	7: 27,578,042 (GRCm39)	C371S	probably damaging	Het

Other mutations in Vmn1r169

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn1r169	APN	7	23,277,019 (GRCm39)	missense	probably damaging	1.00
IGL01667:Vmn1r169	APN	7	23,277,225 (GRCm39)	missense	probably benign	0.17
IGL02246:Vmn1r169	APN	7	23,276,661 (GRCm39)	missense	probably benign	0.09
IGL03303:Vmn1r169	APN	7	23,277,434 (GRCm39)	missense	probably benign	0.40
R1345:Vmn1r169	UTSW	7	23,277,247 (GRCm39)	missense	probably damaging	1.00
R6471:Vmn1r169	UTSW	7	23,276,970 (GRCm39)	missense	probably benign	0.25
R7120:Vmn1r169	UTSW	7	23,277,444 (GRCm39)	missense	probably benign	0.00
R7268:Vmn1r169	UTSW	7	23,276,853 (GRCm39)	missense	probably benign	0.00
R7541:Vmn1r169	UTSW	7	23,277,412 (GRCm39)	missense	probably benign	0.04
R8782:Vmn1r169	UTSW	7	23,277,403 (GRCm39)	missense	possibly damaging	0.92
R8946:Vmn1r169	UTSW	7	23,276,640 (GRCm39)	missense	possibly damaging	0.81
R9277:Vmn1r169	UTSW	7	23,277,390 (GRCm39)	missense	probably benign	0.19
R9408:Vmn1r169	UTSW	7	23,277,342 (GRCm39)	missense	probably damaging	1.00
R9458:Vmn1r169	UTSW	7	23,276,628 (GRCm39)	missense	possibly damaging	0.47

Posted On

2013-06-28