Incidental Mutation 'R6886:Or8k22'
ID 536935
Institutional Source Beutler Lab
Gene Symbol Or8k22
Ensembl Gene ENSMUSG00000075190
Gene Name olfactory receptor family 8 subfamily K member 22
Synonyms Olfr1054, GA_x6K02T2Q125-47811880-47810942, MOR188-2
MMRRC Submission 044980-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R6886 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 86162760-86163698 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 86163408 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 97 (C97*)
Ref Sequence ENSEMBL: ENSMUSP00000150810 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099895] [ENSMUST00000213205]
AlphaFold Q8VGS7
Predicted Effect probably null
Transcript: ENSMUST00000099895
AA Change: C97*
SMART Domains Protein: ENSMUSP00000097480
Gene: ENSMUSG00000075190
AA Change: C97*

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.8e-49 PFAM
Pfam:7tm_1 41 289 5.5e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213205
AA Change: C97*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp7b A T 8: 22,518,706 (GRCm39) M44K probably benign Het
Bad T C 19: 6,928,702 (GRCm39) probably benign Het
Bbs12 A G 3: 37,373,390 (GRCm39) D61G probably damaging Het
Bcr C T 10: 74,989,769 (GRCm39) R722C probably damaging Het
Carf C A 1: 60,175,413 (GRCm39) probably null Het
Ccdc181 A G 1: 164,107,665 (GRCm39) E116G probably damaging Het
Celsr1 A G 15: 85,915,855 (GRCm39) V706A probably benign Het
Col9a1 T A 1: 24,224,426 (GRCm39) S203T unknown Het
Ctsl T C 13: 64,512,961 (GRCm39) probably null Het
Exosc7 A T 9: 122,965,023 (GRCm39) E277D probably benign Het
Fam20b A T 1: 156,518,081 (GRCm39) W238R probably damaging Het
Fanci A T 7: 79,070,090 (GRCm39) H430L possibly damaging Het
Fstl4 A G 11: 53,077,277 (GRCm39) D678G probably damaging Het
Gm10801 TC TCGGC 2: 98,494,151 (GRCm39) probably benign Het
Gm11569 T A 11: 99,689,247 (GRCm39) probably benign Het
Igfn1 G A 1: 135,901,198 (GRCm39) R306W probably damaging Het
Il6 C T 5: 30,223,201 (GRCm39) probably benign Het
Khdc1c T C 1: 21,439,749 (GRCm39) L100P possibly damaging Het
Kif18a G A 2: 109,127,008 (GRCm39) R314H probably damaging Het
Kif26b A C 1: 178,701,703 (GRCm39) K694T probably damaging Het
Kndc1 A G 7: 139,493,485 (GRCm39) T484A probably benign Het
Lonrf1 T C 8: 36,696,191 (GRCm39) probably null Het
Man1a2 C T 3: 100,563,387 (GRCm39) G169D probably benign Het
Med6 G T 12: 81,638,159 (GRCm39) D17E probably damaging Het
Neb T C 2: 52,110,236 (GRCm39) K204R probably damaging Het
Nhlrc1 T A 13: 47,167,252 (GRCm39) N335I possibly damaging Het
Nlrp12 T C 7: 3,289,313 (GRCm39) M400V probably benign Het
Or7e173 G T 9: 19,938,428 (GRCm39) H269N probably benign Het
Pkhd1 C T 1: 20,417,504 (GRCm39) S2549N probably benign Het
Pramel26 A G 4: 143,539,332 (GRCm39) F54L probably benign Het
Rab4b A C 7: 26,872,381 (GRCm39) L145R probably damaging Het
Rad50 T C 11: 53,577,011 (GRCm39) I526V probably benign Het
Rel T C 11: 23,694,304 (GRCm39) H309R probably benign Het
Rnf2 G T 1: 151,349,017 (GRCm39) N34K possibly damaging Het
Serpina3m G T 12: 104,355,386 (GRCm39) V18F possibly damaging Het
Serpinb9c T C 13: 33,334,310 (GRCm39) K244R probably benign Het
Setbp1 T A 18: 78,900,715 (GRCm39) Y984F probably damaging Het
Slc12a5 T A 2: 164,824,825 (GRCm39) M410K probably benign Het
Smarca4 C T 9: 21,570,127 (GRCm39) A710V probably damaging Het
Snx19 C A 9: 30,340,231 (GRCm39) D456E probably damaging Het
Ssrp1 T A 2: 84,870,280 (GRCm39) D101E probably benign Het
Tax1bp1 A T 6: 52,710,208 (GRCm39) E162D probably benign Het
Tenm4 T A 7: 96,446,599 (GRCm39) M823K possibly damaging Het
Tesk1 A G 4: 43,443,592 (GRCm39) D53G possibly damaging Het
Tnrc6a T A 7: 122,786,668 (GRCm39) S1577T probably benign Het
Tpr A G 1: 150,299,716 (GRCm39) I1270V probably benign Het
Trp53bp2 T C 1: 182,256,608 (GRCm39) probably null Het
Ube4a A T 9: 44,860,141 (GRCm39) I307N probably damaging Het
Unc13b A G 4: 43,170,156 (GRCm39) probably benign Het
Vmn2r3 T C 3: 64,166,927 (GRCm39) K735E probably damaging Het
Vmn2r54 A G 7: 12,366,080 (GRCm39) F285L probably benign Het
Vmn2r81 T G 10: 79,103,988 (GRCm39) S204A possibly damaging Het
Washc1 A G 17: 66,426,061 (GRCm39) D453G probably damaging Het
Zfp329 T A 7: 12,544,025 (GRCm39) I500L probably benign Het
Zfp516 A G 18: 82,975,125 (GRCm39) D441G probably benign Het
Zfp644 T C 5: 106,785,777 (GRCm39) T257A possibly damaging Het
Other mutations in Or8k22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01331:Or8k22 APN 2 86,163,048 (GRCm39) nonsense probably null
IGL02266:Or8k22 APN 2 86,163,323 (GRCm39) missense probably damaging 0.98
IGL02398:Or8k22 APN 2 86,162,868 (GRCm39) nonsense probably null
IGL02535:Or8k22 APN 2 86,163,019 (GRCm39) missense probably damaging 1.00
IGL02590:Or8k22 APN 2 86,163,344 (GRCm39) missense possibly damaging 0.52
IGL02630:Or8k22 APN 2 86,163,212 (GRCm39) missense probably benign 0.39
PIT4151001:Or8k22 UTSW 2 86,163,173 (GRCm39) missense possibly damaging 0.60
R0520:Or8k22 UTSW 2 86,163,475 (GRCm39) missense probably damaging 1.00
R1079:Or8k22 UTSW 2 86,163,185 (GRCm39) missense probably damaging 0.96
R1887:Or8k22 UTSW 2 86,163,617 (GRCm39) missense possibly damaging 0.90
R2037:Or8k22 UTSW 2 86,162,774 (GRCm39) missense probably benign 0.03
R2120:Or8k22 UTSW 2 86,163,689 (GRCm39) missense probably benign 0.00
R2153:Or8k22 UTSW 2 86,162,872 (GRCm39) missense probably damaging 1.00
R4523:Or8k22 UTSW 2 86,163,644 (GRCm39) missense probably benign 0.12
R4836:Or8k22 UTSW 2 86,163,571 (GRCm39) missense probably benign 0.12
R6147:Or8k22 UTSW 2 86,162,844 (GRCm39) missense probably damaging 1.00
R6802:Or8k22 UTSW 2 86,163,529 (GRCm39) missense possibly damaging 0.91
R6894:Or8k22 UTSW 2 86,163,295 (GRCm39) missense probably damaging 1.00
R7275:Or8k22 UTSW 2 86,163,136 (GRCm39) missense possibly damaging 0.91
R7322:Or8k22 UTSW 2 86,162,908 (GRCm39) missense probably benign 0.14
R7325:Or8k22 UTSW 2 86,163,344 (GRCm39) missense possibly damaging 0.52
R7526:Or8k22 UTSW 2 86,163,697 (GRCm39) start codon destroyed probably null 1.00
R7976:Or8k22 UTSW 2 86,163,064 (GRCm39) missense probably benign 0.05
R8421:Or8k22 UTSW 2 86,163,247 (GRCm39) missense possibly damaging 0.80
R8838:Or8k22 UTSW 2 86,163,317 (GRCm39) missense possibly damaging 0.61
R9297:Or8k22 UTSW 2 86,163,188 (GRCm39) missense probably benign 0.01
Z1176:Or8k22 UTSW 2 86,163,050 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TATCGCAGAAATGACTAACGATCC -3'
(R):5'- GCAACATGGGCATGATCATC -3'

Sequencing Primer
(F):5'- GAAATGACTAACGATCCTGTAATCAC -3'
(R):5'- ATGGGCATGATCATCCTTACCATGG -3'
Posted On 2018-10-18