Incidental Mutation 'R6886:Vmn2r81'
ID 536964
Institutional Source Beutler Lab
Gene Symbol Vmn2r81
Ensembl Gene ENSMUSG00000055515
Gene Name vomeronasal 2, receptor 81
Synonyms pheromone recepter, V2rf2, EC1-VR2
MMRRC Submission 044980-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R6886 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 79083611-79130369 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 79103988 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 204 (S204A)
Ref Sequence ENSEMBL: ENSMUSP00000020547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020547]
AlphaFold Q80Z09
Predicted Effect possibly damaging
Transcript: ENSMUST00000020547
AA Change: S204A

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000020547
Gene: ENSMUSG00000055515
AA Change: S204A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 79 474 7.7e-37 PFAM
Pfam:NCD3G 517 570 8.9e-21 PFAM
Pfam:7tm_3 603 838 6.1e-50 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit vomeronasal sensory neuron axons that spread out diffusely over the posterior accessory olfactory bulb and extend abnormally into the anterior olfactory bulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp7b A T 8: 22,518,706 (GRCm39) M44K probably benign Het
Bad T C 19: 6,928,702 (GRCm39) probably benign Het
Bbs12 A G 3: 37,373,390 (GRCm39) D61G probably damaging Het
Bcr C T 10: 74,989,769 (GRCm39) R722C probably damaging Het
Carf C A 1: 60,175,413 (GRCm39) probably null Het
Ccdc181 A G 1: 164,107,665 (GRCm39) E116G probably damaging Het
Celsr1 A G 15: 85,915,855 (GRCm39) V706A probably benign Het
Col9a1 T A 1: 24,224,426 (GRCm39) S203T unknown Het
Ctsl T C 13: 64,512,961 (GRCm39) probably null Het
Exosc7 A T 9: 122,965,023 (GRCm39) E277D probably benign Het
Fam20b A T 1: 156,518,081 (GRCm39) W238R probably damaging Het
Fanci A T 7: 79,070,090 (GRCm39) H430L possibly damaging Het
Fstl4 A G 11: 53,077,277 (GRCm39) D678G probably damaging Het
Gm10801 TC TCGGC 2: 98,494,151 (GRCm39) probably benign Het
Gm11569 T A 11: 99,689,247 (GRCm39) probably benign Het
Igfn1 G A 1: 135,901,198 (GRCm39) R306W probably damaging Het
Il6 C T 5: 30,223,201 (GRCm39) probably benign Het
Khdc1c T C 1: 21,439,749 (GRCm39) L100P possibly damaging Het
Kif18a G A 2: 109,127,008 (GRCm39) R314H probably damaging Het
Kif26b A C 1: 178,701,703 (GRCm39) K694T probably damaging Het
Kndc1 A G 7: 139,493,485 (GRCm39) T484A probably benign Het
Lonrf1 T C 8: 36,696,191 (GRCm39) probably null Het
Man1a2 C T 3: 100,563,387 (GRCm39) G169D probably benign Het
Med6 G T 12: 81,638,159 (GRCm39) D17E probably damaging Het
Neb T C 2: 52,110,236 (GRCm39) K204R probably damaging Het
Nhlrc1 T A 13: 47,167,252 (GRCm39) N335I possibly damaging Het
Nlrp12 T C 7: 3,289,313 (GRCm39) M400V probably benign Het
Or7e173 G T 9: 19,938,428 (GRCm39) H269N probably benign Het
Or8k22 A T 2: 86,163,408 (GRCm39) C97* probably null Het
Pkhd1 C T 1: 20,417,504 (GRCm39) S2549N probably benign Het
Pramel26 A G 4: 143,539,332 (GRCm39) F54L probably benign Het
Rab4b A C 7: 26,872,381 (GRCm39) L145R probably damaging Het
Rad50 T C 11: 53,577,011 (GRCm39) I526V probably benign Het
Rel T C 11: 23,694,304 (GRCm39) H309R probably benign Het
Rnf2 G T 1: 151,349,017 (GRCm39) N34K possibly damaging Het
Serpina3m G T 12: 104,355,386 (GRCm39) V18F possibly damaging Het
Serpinb9c T C 13: 33,334,310 (GRCm39) K244R probably benign Het
Setbp1 T A 18: 78,900,715 (GRCm39) Y984F probably damaging Het
Slc12a5 T A 2: 164,824,825 (GRCm39) M410K probably benign Het
Smarca4 C T 9: 21,570,127 (GRCm39) A710V probably damaging Het
Snx19 C A 9: 30,340,231 (GRCm39) D456E probably damaging Het
Ssrp1 T A 2: 84,870,280 (GRCm39) D101E probably benign Het
Tax1bp1 A T 6: 52,710,208 (GRCm39) E162D probably benign Het
Tenm4 T A 7: 96,446,599 (GRCm39) M823K possibly damaging Het
Tesk1 A G 4: 43,443,592 (GRCm39) D53G possibly damaging Het
Tnrc6a T A 7: 122,786,668 (GRCm39) S1577T probably benign Het
Tpr A G 1: 150,299,716 (GRCm39) I1270V probably benign Het
Trp53bp2 T C 1: 182,256,608 (GRCm39) probably null Het
Ube4a A T 9: 44,860,141 (GRCm39) I307N probably damaging Het
Unc13b A G 4: 43,170,156 (GRCm39) probably benign Het
Vmn2r3 T C 3: 64,166,927 (GRCm39) K735E probably damaging Het
Vmn2r54 A G 7: 12,366,080 (GRCm39) F285L probably benign Het
Washc1 A G 17: 66,426,061 (GRCm39) D453G probably damaging Het
Zfp329 T A 7: 12,544,025 (GRCm39) I500L probably benign Het
Zfp516 A G 18: 82,975,125 (GRCm39) D441G probably benign Het
Zfp644 T C 5: 106,785,777 (GRCm39) T257A possibly damaging Het
Other mutations in Vmn2r81
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01111:Vmn2r81 APN 10 79,083,831 (GRCm39) missense probably benign 0.20
IGL02255:Vmn2r81 APN 10 79,083,806 (GRCm39) nonsense probably null
IGL02901:Vmn2r81 APN 10 79,106,564 (GRCm39) missense probably damaging 0.98
R0383:Vmn2r81 UTSW 10 79,129,281 (GRCm39) missense possibly damaging 0.95
R0555:Vmn2r81 UTSW 10 79,129,283 (GRCm39) missense probably damaging 1.00
R0715:Vmn2r81 UTSW 10 79,104,434 (GRCm39) missense probably damaging 1.00
R0967:Vmn2r81 UTSW 10 79,083,857 (GRCm39) splice site probably benign
R1438:Vmn2r81 UTSW 10 79,129,691 (GRCm39) missense probably benign 0.00
R1468:Vmn2r81 UTSW 10 79,129,496 (GRCm39) missense probably damaging 1.00
R1468:Vmn2r81 UTSW 10 79,129,496 (GRCm39) missense probably damaging 1.00
R1589:Vmn2r81 UTSW 10 79,128,858 (GRCm39) missense probably damaging 0.99
R1671:Vmn2r81 UTSW 10 79,103,265 (GRCm39) missense probably benign 0.04
R1672:Vmn2r81 UTSW 10 79,104,112 (GRCm39) missense probably damaging 0.99
R1728:Vmn2r81 UTSW 10 79,106,489 (GRCm39) missense probably benign 0.08
R1784:Vmn2r81 UTSW 10 79,106,489 (GRCm39) missense probably benign 0.08
R1931:Vmn2r81 UTSW 10 79,129,328 (GRCm39) missense probably damaging 0.98
R1934:Vmn2r81 UTSW 10 79,083,628 (GRCm39) start codon destroyed probably null 0.71
R1944:Vmn2r81 UTSW 10 79,129,571 (GRCm39) missense probably damaging 1.00
R2102:Vmn2r81 UTSW 10 79,129,334 (GRCm39) missense probably damaging 0.97
R2190:Vmn2r81 UTSW 10 79,104,085 (GRCm39) missense possibly damaging 0.67
R2392:Vmn2r81 UTSW 10 79,110,516 (GRCm39) missense probably damaging 1.00
R3770:Vmn2r81 UTSW 10 79,106,434 (GRCm39) missense probably damaging 1.00
R4551:Vmn2r81 UTSW 10 79,104,241 (GRCm39) missense possibly damaging 0.95
R4629:Vmn2r81 UTSW 10 79,103,276 (GRCm39) missense probably damaging 0.99
R4691:Vmn2r81 UTSW 10 79,129,211 (GRCm39) nonsense probably null
R4829:Vmn2r81 UTSW 10 79,083,635 (GRCm39) missense possibly damaging 0.48
R4914:Vmn2r81 UTSW 10 79,106,357 (GRCm39) missense probably null 1.00
R4996:Vmn2r81 UTSW 10 79,129,247 (GRCm39) missense probably benign 0.04
R5242:Vmn2r81 UTSW 10 79,129,309 (GRCm39) nonsense probably null
R5253:Vmn2r81 UTSW 10 79,083,820 (GRCm39) missense probably benign 0.00
R5925:Vmn2r81 UTSW 10 79,083,637 (GRCm39) missense probably damaging 1.00
R6169:Vmn2r81 UTSW 10 79,104,382 (GRCm39) missense probably benign
R6270:Vmn2r81 UTSW 10 79,129,649 (GRCm39) missense probably benign
R6525:Vmn2r81 UTSW 10 79,129,560 (GRCm39) missense probably benign 0.11
R6813:Vmn2r81 UTSW 10 79,104,439 (GRCm39) missense probably benign 0.00
R7200:Vmn2r81 UTSW 10 79,106,570 (GRCm39) critical splice donor site probably null
R7350:Vmn2r81 UTSW 10 79,104,219 (GRCm39) missense probably benign 0.03
R7504:Vmn2r81 UTSW 10 79,104,166 (GRCm39) missense probably benign
R7832:Vmn2r81 UTSW 10 79,129,664 (GRCm39) missense probably damaging 1.00
R8130:Vmn2r81 UTSW 10 79,110,538 (GRCm39) missense possibly damaging 0.95
R8362:Vmn2r81 UTSW 10 79,103,283 (GRCm39) missense probably benign 0.17
R8407:Vmn2r81 UTSW 10 79,104,028 (GRCm39) missense possibly damaging 0.92
R8540:Vmn2r81 UTSW 10 79,129,065 (GRCm39) missense probably damaging 0.99
R8558:Vmn2r81 UTSW 10 79,106,467 (GRCm39) missense possibly damaging 0.94
R8700:Vmn2r81 UTSW 10 79,129,517 (GRCm39) missense probably damaging 1.00
R8779:Vmn2r81 UTSW 10 79,103,218 (GRCm39) missense possibly damaging 0.78
R8987:Vmn2r81 UTSW 10 79,129,704 (GRCm39) missense probably damaging 1.00
R9001:Vmn2r81 UTSW 10 79,104,104 (GRCm39) missense possibly damaging 0.73
R9055:Vmn2r81 UTSW 10 79,110,441 (GRCm39) missense probably benign
R9145:Vmn2r81 UTSW 10 79,104,028 (GRCm39) missense possibly damaging 0.92
R9151:Vmn2r81 UTSW 10 79,103,905 (GRCm39) missense
R9253:Vmn2r81 UTSW 10 79,129,582 (GRCm39) missense probably damaging 1.00
R9255:Vmn2r81 UTSW 10 79,103,166 (GRCm39) missense possibly damaging 0.77
R9370:Vmn2r81 UTSW 10 79,104,424 (GRCm39) missense probably damaging 1.00
R9588:Vmn2r81 UTSW 10 79,129,205 (GRCm39) missense possibly damaging 0.46
X0067:Vmn2r81 UTSW 10 79,128,877 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- GACCTGTTTGCAAAATGAAAGATAC -3'
(R):5'- CTTGTGATATCAAACGAAGTAGGG -3'

Sequencing Primer
(F):5'- ATGAGATCCTGCTGCAATGC -3'
(R):5'- TCAAACGAAGTAGGGTTTCCC -3'
Posted On 2018-10-18