Incidental Mutation 'R6886:Gm11569'
ID536968
Institutional Source Beutler Lab
Gene Symbol Gm11569
Ensembl Gene ENSMUSG00000078260
Gene Namepredicted gene 11569
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Not available question?
Stock #R6886 (G1)
Quality Score209.009
Status Not validated
Chromosome11
Chromosomal Location99798064-99798932 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to A at 99798421 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000100679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105057] [ENSMUST00000105058]
Predicted Effect unknown
Transcript: ENSMUST00000105057
AA Change: I151F
SMART Domains Protein: ENSMUSP00000100678
Gene: ENSMUSG00000078260
AA Change: I151F

DomainStartEndE-ValueType
Pfam:Keratin_B2_2 1 52 1.2e-9 PFAM
Pfam:Keratin_B2 1 79 3.8e-12 PFAM
Pfam:Keratin_B2_2 39 83 1.1e-14 PFAM
Pfam:Keratin_B2_2 79 128 3.7e-10 PFAM
Pfam:Keratin_B2_2 101 148 1.7e-9 PFAM
Pfam:Keratin_B2_2 114 158 9.9e-13 PFAM
Pfam:Keratin_B2_2 139 180 4.9e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105058
SMART Domains Protein: ENSMUSP00000100679
Gene: ENSMUSG00000078261

DomainStartEndE-ValueType
Pfam:Keratin_B2_2 1 48 2.7e-9 PFAM
Pfam:Keratin_B2 1 69 1.9e-10 PFAM
Pfam:Keratin_B2_2 14 58 1.1e-13 PFAM
Pfam:Keratin_B2_2 39 86 4.7e-11 PFAM
Pfam:Keratin_B2_2 84 128 8.2e-13 PFAM
Pfam:Keratin_B2_2 129 173 5.2e-12 PFAM
Pfam:Keratin_B2_2 164 205 3.7e-9 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp7b A T 8: 22,028,690 M44K probably benign Het
Bad T C 19: 6,951,334 probably benign Het
Bbs12 A G 3: 37,319,241 D61G probably damaging Het
Bcr C T 10: 75,153,937 R722C probably damaging Het
Carf C A 1: 60,136,254 probably null Het
Ccdc181 A G 1: 164,280,096 E116G probably damaging Het
Celsr1 A G 15: 86,031,654 V706A probably benign Het
Col9a1 T A 1: 24,185,345 S203T unknown Het
Ctsl T C 13: 64,365,147 probably null Het
Exosc7 A T 9: 123,135,958 E277D probably benign Het
Fam20b A T 1: 156,690,511 W238R probably damaging Het
Fanci A T 7: 79,420,342 H430L possibly damaging Het
Fstl4 A G 11: 53,186,450 D678G probably damaging Het
Gm10801 TC TCGGC 2: 98,663,806 probably benign Het
Gm13084 A G 4: 143,812,762 F54L probably benign Het
Igfn1 G A 1: 135,973,460 R306W probably damaging Het
Il6 C T 5: 30,018,203 probably benign Het
Khdc1c T C 1: 21,369,525 L100P possibly damaging Het
Kif18a G A 2: 109,296,663 R314H probably damaging Het
Kif26b A C 1: 178,874,138 K694T probably damaging Het
Kndc1 A G 7: 139,913,569 T484A probably benign Het
Lonrf1 T C 8: 36,229,037 probably null Het
Man1a2 C T 3: 100,656,071 G169D probably benign Het
Med6 G T 12: 81,591,385 D17E probably damaging Het
Neb T C 2: 52,220,224 K204R probably damaging Het
Nhlrc1 T A 13: 47,013,776 N335I possibly damaging Het
Nlrp12 T C 7: 3,240,683 M400V probably benign Het
Olfr1054 A T 2: 86,333,064 C97* probably null Het
Olfr866 G T 9: 20,027,132 H269N probably benign Het
Pkhd1 C T 1: 20,347,280 S2549N probably benign Het
Rab4b A C 7: 27,172,956 L145R probably damaging Het
Rad50 T C 11: 53,686,184 I526V probably benign Het
Rel T C 11: 23,744,304 H309R probably benign Het
Rnf2 G T 1: 151,473,266 N34K possibly damaging Het
Serpina3m G T 12: 104,389,127 V18F possibly damaging Het
Serpinb9c T C 13: 33,150,327 K244R probably benign Het
Setbp1 T A 18: 78,857,500 Y984F probably damaging Het
Slc12a5 T A 2: 164,982,905 M410K probably benign Het
Smarca4 C T 9: 21,658,831 A710V probably damaging Het
Snx19 C A 9: 30,428,935 D456E probably damaging Het
Ssrp1 T A 2: 85,039,936 D101E probably benign Het
Tax1bp1 A T 6: 52,733,223 E162D probably benign Het
Tenm4 T A 7: 96,797,392 M823K possibly damaging Het
Tesk1 A G 4: 43,443,592 D53G possibly damaging Het
Tnrc6a T A 7: 123,187,445 S1577T probably benign Het
Tpr A G 1: 150,423,965 I1270V probably benign Het
Trp53bp2 T C 1: 182,429,043 probably null Het
Ube4a A T 9: 44,948,843 I307N probably damaging Het
Unc13b A G 4: 43,170,156 probably benign Het
Vmn2r3 T C 3: 64,259,506 K735E probably damaging Het
Vmn2r54 A G 7: 12,632,153 F285L probably benign Het
Vmn2r81 T G 10: 79,268,154 S204A possibly damaging Het
Washc1 A G 17: 66,119,066 D453G probably damaging Het
Zfp329 T A 7: 12,810,098 I500L probably benign Het
Zfp516 A G 18: 82,957,000 D441G probably benign Het
Zfp644 T C 5: 106,637,911 T257A possibly damaging Het
Other mutations in Gm11569
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4486001:Gm11569 UTSW 11 99798665 small deletion probably benign
R0968:Gm11569 UTSW 11 99798424 unclassified probably benign
R5696:Gm11569 UTSW 11 99798730 unclassified probably benign
R6789:Gm11569 UTSW 11 99798831 unclassified probably benign
R8007:Gm11569 UTSW 11 99798862 missense unknown
R8047:Gm11569 UTSW 11 99798790 missense unknown
Predicted Primers PCR Primer
(F):5'- AATGAGCCTCTTGGGACTCAG -3'
(R):5'- TGCATTTCCAGCTGCTGCAG -3'

Sequencing Primer
(F):5'- TCTTGGGACTCAGAACACACATGG -3'
(R):5'- CCCAGCTGTTGTGTGTCCAG -3'
Posted On2018-10-18