Incidental Mutation 'R6888:Zfp882'
ID 537052
Institutional Source Beutler Lab
Gene Symbol Zfp882
Ensembl Gene ENSMUSG00000089857
Gene Name zinc finger protein 882
Synonyms ENSMUSG00000052439
MMRRC Submission 044982-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R6888 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 71908608-71916354 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 71914286 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 319 (C319Y)
Ref Sequence ENSEMBL: ENSMUSP00000105629 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110002] [ENSMUST00000125802] [ENSMUST00000126607] [ENSMUST00000131544]
AlphaFold E9Q4R4
Predicted Effect probably benign
Transcript: ENSMUST00000110002
AA Change: C319Y

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000105629
Gene: ENSMUSG00000089857
AA Change: C319Y

DomainStartEndE-ValueType
KRAB 4 61 8.58e-14 SMART
ZnF_C2H2 84 106 1.47e-3 SMART
ZnF_C2H2 168 190 8.47e-4 SMART
ZnF_C2H2 196 218 2.27e-4 SMART
ZnF_C2H2 224 246 6.31e1 SMART
ZnF_C2H2 251 273 1.16e-1 SMART
ZnF_C2H2 279 301 1.25e-1 SMART
ZnF_C2H2 307 329 5.42e-2 SMART
ZnF_C2H2 335 357 1.47e-3 SMART
ZnF_C2H2 363 385 7.26e-3 SMART
ZnF_C2H2 391 413 1.26e-2 SMART
ZnF_C2H2 419 441 3.29e1 SMART
ZnF_C2H2 447 469 2.67e-1 SMART
ZnF_C2H2 475 497 1.04e-3 SMART
ZnF_C2H2 503 525 4.11e-2 SMART
ZnF_C2H2 531 553 4.87e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125802
SMART Domains Protein: ENSMUSP00000121316
Gene: ENSMUSG00000089857

DomainStartEndE-ValueType
KRAB 12 69 8.58e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126607
SMART Domains Protein: ENSMUSP00000119978
Gene: ENSMUSG00000089857

DomainStartEndE-ValueType
KRAB 44 101 8.58e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131544
SMART Domains Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880

DomainStartEndE-ValueType
KRAB 4 56 1.08e-10 SMART
ZnF_C2H2 167 189 8.47e-4 SMART
ZnF_C2H2 195 217 8.34e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110051M20Rik A G 2: 91,421,894 (GRCm38) Y41H probably damaging Het
Actg1 T C 11: 120,347,315 (GRCm38) Y190C probably damaging Het
Adgrv1 A G 13: 81,508,669 (GRCm38) I2902T probably damaging Het
AI429214 G A 8: 36,993,833 (GRCm38) G45D possibly damaging Het
Ambra1 A G 2: 91,769,027 (GRCm38) D164G probably damaging Het
Ap3b1 A T 13: 94,408,791 (GRCm38) Q184L probably benign Het
Arhgef17 T C 7: 100,930,820 (GRCm38) D307G possibly damaging Het
AY761185 A T 8: 20,944,555 (GRCm38) Y52* probably null Het
Bfsp1 A G 2: 143,826,719 (GRCm38) S647P probably benign Het
C130073F10Rik A G 4: 101,890,256 (GRCm38) V192A probably benign Het
Cacna1g T A 11: 94,459,207 (GRCm38) D604V probably benign Het
Ccdc170 T C 10: 4,546,854 (GRCm38) V458A possibly damaging Het
Ccdc187 G A 2: 26,289,734 (GRCm38) R238W probably damaging Het
Cdh1 A G 8: 106,658,314 (GRCm38) S380G probably benign Het
Cdk5rap3 T C 11: 96,916,192 (GRCm38) H4R probably benign Het
Cftr G A 6: 18,313,730 (GRCm38) probably null Het
Dnajc16 A G 4: 141,776,992 (GRCm38) V219A probably benign Het
Drd3 A T 16: 43,817,139 (GRCm38) I266F probably benign Het
Dut A G 2: 125,257,124 (GRCm38) D177G probably benign Het
Esr1 A G 10: 4,857,076 (GRCm38) I331V probably benign Het
Fam129c G T 8: 71,603,739 (GRCm38) R361L probably benign Het
Gm11110 A G 17: 57,102,143 (GRCm38) probably benign Het
Grm7 G T 6: 111,358,353 (GRCm38) G575V possibly damaging Het
Heatr3 A G 8: 88,170,884 (GRCm38) Y531C probably damaging Het
Igfn1 A G 1: 135,982,480 (GRCm38) V122A probably benign Het
Igsf21 T C 4: 140,034,743 (GRCm38) D208G probably benign Het
Kntc1 T C 5: 123,811,310 (GRCm38) Y1915H probably damaging Het
Lamc1 A T 1: 153,262,492 (GRCm38) D205E probably damaging Het
Limch1 C T 5: 67,021,926 (GRCm38) T713I probably benign Het
Lrp1b A G 2: 41,471,126 (GRCm38) I555T probably benign Het
Lrp2 A T 2: 69,524,141 (GRCm38) F448I probably damaging Het
March6 T C 15: 31,459,233 (GRCm38) K896E probably benign Het
Mpp6 T G 6: 50,180,277 (GRCm38) probably null Het
Mroh4 T C 15: 74,613,249 (GRCm38) Y469C possibly damaging Het
Nos3 T C 5: 24,383,335 (GRCm38) V1060A possibly damaging Het
Nr1h4 A G 10: 89,456,542 (GRCm38) I406T probably damaging Het
Odf2l T C 3: 145,148,618 (GRCm38) probably null Het
Olfr1162 A G 2: 88,050,264 (GRCm38) M120T probably damaging Het
Olfr1387 A T 11: 49,460,260 (GRCm38) T194S probably damaging Het
Pbx2 A G 17: 34,594,107 (GRCm38) Y119C possibly damaging Het
Pdcd6ip C A 9: 113,671,837 (GRCm38) A526S probably benign Het
Prx G A 7: 27,519,634 (GRCm38) D1187N possibly damaging Het
Ptpro G A 6: 137,380,200 (GRCm38) V230I probably benign Het
Rtn3 C T 19: 7,457,249 (GRCm38) M440I probably benign Het
Sar1b T C 11: 51,788,192 (GRCm38) I96T probably damaging Het
Sds T C 5: 120,480,900 (GRCm38) probably null Het
Secisbp2 A G 13: 51,679,941 (GRCm38) T706A probably benign Het
Sorcs3 A T 19: 48,693,824 (GRCm38) M433L possibly damaging Het
Sppl2a A G 2: 126,904,992 (GRCm38) V472A probably damaging Het
Tbc1d9 A G 8: 83,271,588 (GRCm38) E1258G possibly damaging Het
Tbxas1 C A 6: 38,952,074 (GRCm38) probably benign Het
Tg T C 15: 66,696,246 (GRCm38) I1333T probably damaging Het
Tmem108 C T 9: 103,499,716 (GRCm38) G178D probably damaging Het
Tmem174 A G 13: 98,637,061 (GRCm38) L87P probably damaging Het
Tmppe T A 9: 114,404,701 (GRCm38) S23T probably damaging Het
Ttn G A 2: 76,761,103 (GRCm38) T21074I probably benign Het
Tub A G 7: 109,029,298 (GRCm38) M338V probably null Het
Vmn1r160 A T 7: 22,872,106 (GRCm38) R295* probably null Het
Vps52 T C 17: 33,963,206 (GRCm38) V518A probably benign Het
Wdr59 A G 8: 111,451,043 (GRCm38) V909A probably benign Het
Wnk1 T C 6: 119,948,781 (GRCm38) T1241A probably benign Het
Znfx1 A T 2: 167,038,940 (GRCm38) I308N possibly damaging Het
Other mutations in Zfp882
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00676:Zfp882 APN 8 71,913,827 (GRCm38) missense probably benign
R0244:Zfp882 UTSW 8 71,913,523 (GRCm38) missense possibly damaging 0.79
R0270:Zfp882 UTSW 8 71,914,615 (GRCm38) missense probably benign 0.05
R0636:Zfp882 UTSW 8 71,914,337 (GRCm38) missense probably benign 0.01
R0840:Zfp882 UTSW 8 71,914,686 (GRCm38) nonsense probably null
R1299:Zfp882 UTSW 8 71,913,473 (GRCm38) missense probably damaging 1.00
R4439:Zfp882 UTSW 8 71,913,609 (GRCm38) missense probably damaging 0.97
R4829:Zfp882 UTSW 8 71,914,389 (GRCm38) missense probably damaging 1.00
R5028:Zfp882 UTSW 8 71,914,654 (GRCm38) missense possibly damaging 0.70
R5296:Zfp882 UTSW 8 71,914,360 (GRCm38) missense probably damaging 1.00
R5882:Zfp882 UTSW 8 71,913,459 (GRCm38) critical splice acceptor site probably null
R5974:Zfp882 UTSW 8 71,913,155 (GRCm38) missense probably damaging 1.00
R6052:Zfp882 UTSW 8 71,914,505 (GRCm38) missense probably benign 0.01
R6383:Zfp882 UTSW 8 71,914,640 (GRCm38) missense probably damaging 1.00
R6987:Zfp882 UTSW 8 71,914,673 (GRCm38) missense probably benign 0.01
R7045:Zfp882 UTSW 8 71,913,249 (GRCm38) critical splice donor site probably null
R7780:Zfp882 UTSW 8 71,914,229 (GRCm38) missense possibly damaging 0.89
R7793:Zfp882 UTSW 8 71,913,141 (GRCm38) missense probably damaging 1.00
R8386:Zfp882 UTSW 8 71,914,118 (GRCm38) missense probably benign 0.00
R9452:Zfp882 UTSW 8 71,914,987 (GRCm38) missense probably damaging 1.00
R9694:Zfp882 UTSW 8 71,914,071 (GRCm38) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTTTGAGGAAGGTTGAAAGTCATG -3'
(R):5'- CCTGTGAATCTGTTCATGGTATC -3'

Sequencing Primer
(F):5'- GGGATAGCCTTCAGTGATCAC -3'
(R):5'- GAATCTGTTCATGGTATCGAAGAGC -3'
Posted On 2018-10-18