Incidental Mutation 'IGL01023:Zfp78'
ID53706
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp78
Ensembl Gene ENSMUSG00000055150
Gene Namezinc finger protein 78
SynonymsKRAB12, Zfp77
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL01023
Quality Score
Status
Chromosome7
Chromosomal Location6363280-6382605 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 6375588 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Aspartic acid at position 77 (G77D)
Ref Sequence ENSEMBL: ENSMUSP00000147154 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086323] [ENSMUST00000108559] [ENSMUST00000207314] [ENSMUST00000207347] [ENSMUST00000208030] [ENSMUST00000208390] [ENSMUST00000208763]
Predicted Effect probably benign
Transcript: ENSMUST00000086323
SMART Domains Protein: ENSMUSP00000083503
Gene: ENSMUSG00000055150

DomainStartEndE-ValueType
KRAB 14 74 1.07e-23 SMART
low complexity region 148 159 N/A INTRINSIC
ZnF_C2H2 173 195 3.39e-3 SMART
ZnF_C2H2 201 223 2.36e-2 SMART
ZnF_C2H2 229 251 3.63e-3 SMART
ZnF_C2H2 257 279 3.89e-3 SMART
ZnF_C2H2 285 307 3.95e-4 SMART
ZnF_C2H2 313 335 1.69e-3 SMART
ZnF_C2H2 341 363 5.21e-4 SMART
ZnF_C2H2 369 391 1.38e-3 SMART
ZnF_C2H2 397 419 9.88e-5 SMART
ZnF_C2H2 425 447 7.67e-2 SMART
ZnF_C2H2 453 475 6.32e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000108559
AA Change: G77D

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000104199
Gene: ENSMUSG00000055150
AA Change: G77D

DomainStartEndE-ValueType
KRAB 14 74 3.12e-34 SMART
low complexity region 180 191 N/A INTRINSIC
ZnF_C2H2 205 227 3.39e-3 SMART
ZnF_C2H2 233 255 2.36e-2 SMART
ZnF_C2H2 261 283 3.63e-3 SMART
ZnF_C2H2 289 311 3.89e-3 SMART
ZnF_C2H2 317 339 3.95e-4 SMART
ZnF_C2H2 345 367 1.69e-3 SMART
ZnF_C2H2 373 395 5.21e-4 SMART
ZnF_C2H2 401 423 1.38e-3 SMART
ZnF_C2H2 429 451 9.88e-5 SMART
ZnF_C2H2 457 479 7.67e-2 SMART
ZnF_C2H2 485 507 6.32e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000207314
Predicted Effect possibly damaging
Transcript: ENSMUST00000207347
AA Change: G77D

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000208030
Predicted Effect probably benign
Transcript: ENSMUST00000208390
Predicted Effect possibly damaging
Transcript: ENSMUST00000208763
AA Change: G77D

PolyPhen 2 Score 0.880 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc1 A G 2: 128,629,729 L1472P probably damaging Het
BC005561 T A 5: 104,520,500 W963R probably damaging Het
Col18a1 C T 10: 77,070,975 V1151M probably damaging Het
Crmp1 A T 5: 37,276,313 D286V probably damaging Het
Ddx60 A T 8: 61,942,514 I162F probably damaging Het
Fam24b A T 7: 131,326,174 C95* probably null Het
Fsd1 A G 17: 55,988,245 Y78C probably damaging Het
Galc C T 12: 98,231,422 V343I probably benign Het
Glis2 C T 16: 4,611,650 R214C probably damaging Het
Gm14406 A T 2: 177,569,239 C416S probably damaging Het
Gm5724 A G 6: 141,754,429 S126P probably benign Het
Gnat3 T C 5: 18,003,828 S177P probably damaging Het
Higd1a C T 9: 121,849,683 G80D possibly damaging Het
Hp1bp3 T C 4: 138,240,629 V421A possibly damaging Het
Ipo11 A T 13: 106,897,259 F238L probably benign Het
Med26 A T 8: 72,495,874 F460L possibly damaging Het
Olfr1111 T A 2: 87,149,825 T279S possibly damaging Het
Osbp2 T C 11: 3,863,387 I161V probably benign Het
Prr5 T C 15: 84,699,655 V152A possibly damaging Het
Prx T A 7: 27,519,419 I1115K probably benign Het
Ptpn22 A G 3: 103,903,374 I708M probably benign Het
Robo3 T C 9: 37,429,551 T120A probably damaging Het
Setd2 C A 9: 110,547,513 S132* probably null Het
Slc9a1 A G 4: 133,422,143 E760G probably benign Het
Stx16 A T 2: 174,092,409 H135L probably damaging Het
Tas2r131 A T 6: 132,957,801 L15Q probably damaging Het
Tmcc1 A G 6: 116,043,027 L128P probably damaging Het
Tmem269 C A 4: 119,209,314 M182I probably benign Het
Tnfaip8l2 A G 3: 95,140,415 S46P probably damaging Het
Trim30c A G 7: 104,382,972 probably benign Het
Unc13a C T 8: 71,661,825 E184K probably benign Het
Wfs1 A T 5: 36,967,917 C467* probably null Het
Other mutations in Zfp78
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0502:Zfp78 UTSW 7 6373158 missense probably damaging 1.00
R0704:Zfp78 UTSW 7 6379252 missense probably damaging 1.00
R1035:Zfp78 UTSW 7 6378661 missense probably damaging 1.00
R1402:Zfp78 UTSW 7 6378619 missense probably damaging 1.00
R1402:Zfp78 UTSW 7 6378619 missense probably damaging 1.00
R1908:Zfp78 UTSW 7 6378898 missense probably damaging 0.97
R1955:Zfp78 UTSW 7 6378559 missense probably benign 0.00
R2004:Zfp78 UTSW 7 6379075 missense probably damaging 1.00
R2025:Zfp78 UTSW 7 6375514 splice site probably null
R2357:Zfp78 UTSW 7 6379057 missense probably damaging 1.00
R5503:Zfp78 UTSW 7 6378529 missense probably benign
R6742:Zfp78 UTSW 7 6378278 missense probably damaging 0.97
R6996:Zfp78 UTSW 7 6378765 missense probably benign 0.38
Posted On2013-06-28