Incidental Mutation 'R6890:Zfp617'
ID537158
Institutional Source Beutler Lab
Gene Symbol Zfp617
Ensembl Gene ENSMUSG00000066880
Gene Namezinc finger protein 617
SynonymsZfps11-6, Zinc finger protein s11-6
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.366) question?
Stock #R6890 (G1)
Quality Score225.009
Status Validated
Chromosome8
Chromosomal Location71908635-71934629 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 71932166 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Glutamine at position 113 (H113Q)
Ref Sequence ENSEMBL: ENSMUSP00000120213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119003] [ENSMUST00000131544]
Predicted Effect probably benign
Transcript: ENSMUST00000119003
AA Change: H113Q

PolyPhen 2 Score 0.352 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000112926
Gene: ENSMUSG00000066880
AA Change: H113Q

DomainStartEndE-ValueType
KRAB 4 56 1.08e-10 SMART
ZnF_C2H2 167 189 8.47e-4 SMART
ZnF_C2H2 195 217 8.34e-3 SMART
ZnF_C2H2 223 245 1.28e-3 SMART
ZnF_C2H2 251 273 1.28e-3 SMART
ZnF_C2H2 279 301 1.58e-3 SMART
ZnF_C2H2 307 329 1.28e-3 SMART
ZnF_C2H2 335 357 9.73e-4 SMART
ZnF_C2H2 363 385 6.42e-4 SMART
ZnF_C2H2 391 413 4.47e-3 SMART
ZnF_C2H2 419 441 1.38e-3 SMART
ZnF_C2H2 447 469 1.2e-3 SMART
ZnF_C2H2 475 497 1.56e-2 SMART
ZnF_C2H2 503 525 2.36e-2 SMART
ZnF_C2H2 531 553 4.98e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131544
AA Change: H113Q

PolyPhen 2 Score 0.352 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880
AA Change: H113Q

DomainStartEndE-ValueType
KRAB 4 56 1.08e-10 SMART
ZnF_C2H2 167 189 8.47e-4 SMART
ZnF_C2H2 195 217 8.34e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik A G 19: 45,960,357 Y228H probably damaging Het
Alg3 T C 16: 20,605,986 T270A possibly damaging Het
Ambp G C 4: 63,150,359 H140Q probably benign Het
Arhgef10 T C 8: 14,928,786 C18R probably benign Het
Arhgef10l A G 4: 140,544,419 F548S probably damaging Het
Cdhr1 T C 14: 37,085,645 D346G probably damaging Het
Col18a1 T A 10: 77,113,484 probably benign Het
Col1a2 T A 6: 4,539,587 L1285Q unknown Het
Cspg5 T C 9: 110,246,784 L196P probably damaging Het
Dusp10 T G 1: 184,069,196 Y387D probably damaging Het
Epb41 A T 4: 131,935,829 D681E probably damaging Het
Eps8 A G 6: 137,512,257 V381A probably damaging Het
Fam129c T A 8: 71,605,671 V540D probably damaging Het
Fbxw16 A T 9: 109,436,742 S336R probably benign Het
Gm49368 A G 7: 128,081,729 R277G probably benign Het
Gsg1 C T 6: 135,237,420 V320I probably benign Het
Iglc3 T A 16: 19,065,508 probably benign Het
Klc4 A T 17: 46,631,843 N598K probably benign Het
Malsu1 A G 6: 49,075,251 Y135C probably damaging Het
Mapkbp1 T C 2: 120,015,802 I477T probably damaging Het
Mtss1 G T 15: 58,951,659 S286R probably damaging Het
Naip2 A C 13: 100,162,041 S496A probably benign Het
Npepps A T 11: 97,267,644 C98* probably null Het
Nphp3 A C 9: 104,041,954 Y1267S probably damaging Het
Npr3 A G 15: 11,883,392 V317A possibly damaging Het
Nsun6 A G 2: 15,048,977 I7T probably damaging Het
Olfr1342 A G 4: 118,689,531 V307A possibly damaging Het
Olfr1480 C T 19: 13,530,081 T180I probably damaging Het
Olfr632 A T 7: 103,937,859 T160S possibly damaging Het
Pcnx A G 12: 81,971,376 H1330R probably benign Het
Rad17 T C 13: 100,637,084 I201V probably benign Het
Slc26a4 G A 12: 31,549,951 T126M possibly damaging Het
Slitrk6 A T 14: 110,751,096 L393* probably null Het
Snx2 A G 18: 53,212,879 H378R probably damaging Het
Tex21 A G 12: 76,239,455 probably null Het
Trio A T 15: 27,919,288 probably benign Het
Vpreb2 T C 16: 17,980,956 I102T probably damaging Het
Zgpat T A 2: 181,378,511 I237N probably damaging Het
Other mutations in Zfp617
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00671:Zfp617 APN 8 71932542 nonsense probably null
R2116:Zfp617 UTSW 8 71932165 missense probably benign 0.05
R3840:Zfp617 UTSW 8 71932117 missense probably damaging 1.00
R3841:Zfp617 UTSW 8 71932117 missense probably damaging 1.00
R4587:Zfp617 UTSW 8 71929159 missense probably damaging 0.98
R4691:Zfp617 UTSW 8 71932815 missense probably benign 0.13
R5264:Zfp617 UTSW 8 71933041 missense probably damaging 0.98
R5783:Zfp617 UTSW 8 71932464 missense probably damaging 1.00
R6046:Zfp617 UTSW 8 71933413 missense probably damaging 1.00
R6197:Zfp617 UTSW 8 71933254 missense probably benign 0.01
R6403:Zfp617 UTSW 8 71929171 missense probably benign 0.26
R7124:Zfp617 UTSW 8 71932540 missense probably damaging 1.00
R7582:Zfp617 UTSW 8 71932020 missense probably benign 0.01
R7747:Zfp617 UTSW 8 71928189 splice site probably null
Predicted Primers PCR Primer
(F):5'- CACTGCTTTGACTAGTGGTATTTAAGC -3'
(R):5'- TACAGGCATAGGGTTTCTCTTG -3'

Sequencing Primer
(F):5'- TTAAGCTGTCTTATTGAGTCTTCAC -3'
(R):5'- CTCTTGTGTGTAAATTTGTTCATGC -3'
Posted On2018-10-18