Incidental Mutation 'R6891:Vmn2r10'
ID 537208
Institutional Source Beutler Lab
Gene Symbol Vmn2r10
Ensembl Gene ENSMUSG00000067010
Gene Name vomeronasal 2, receptor 10
Synonyms VR16, V2r16
MMRRC Submission 044985-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R6891 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 109141278-109154337 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 109149845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 400 (V400M)
Ref Sequence ENSEMBL: ENSMUSP00000078162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]
AlphaFold K7N621
Predicted Effect probably damaging
Transcript: ENSMUST00000079163
AA Change: V400M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: V400M

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 75 464 8.5e-29 PFAM
Pfam:NCD3G 506 560 3.8e-17 PFAM
Pfam:7tm_3 593 828 4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176594
SMART Domains Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 97% (72/74)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl11 C T 9: 107,806,346 (GRCm39) A223V probably benign Het
Agbl5 G T 5: 31,052,522 (GRCm39) R61L probably damaging Het
Agmat A T 4: 141,483,192 (GRCm39) T209S probably benign Het
Ankrd34a G A 3: 96,505,335 (GRCm39) V180I probably benign Het
Anks1 C T 17: 28,276,398 (GRCm39) T1047M probably damaging Het
Arhgap21 T A 2: 20,855,142 (GRCm39) I1407F probably damaging Het
Armc1 C A 3: 19,189,205 (GRCm39) C183F probably damaging Het
Atg13 A G 2: 91,516,136 (GRCm39) M196T probably benign Het
AU040320 G T 4: 126,740,231 (GRCm39) S864I possibly damaging Het
Btn2a2 T C 13: 23,667,014 (GRCm39) D197G probably benign Het
Carmil1 A G 13: 24,325,706 (GRCm39) I208T probably benign Het
Cbs T A 17: 31,841,431 (GRCm39) R263S probably damaging Het
Ccdc7a C A 8: 129,753,119 (GRCm39) R204L probably damaging Het
Cdhr1 A T 14: 36,819,334 (GRCm39) probably null Het
Cers4 G A 8: 4,573,731 (GRCm39) R378Q probably damaging Het
Chst1 T G 2: 92,444,088 (GRCm39) L187V probably benign Het
Clec4e A T 6: 123,260,565 (GRCm39) N164K probably damaging Het
Cln3 T A 7: 126,181,975 (GRCm39) D29V possibly damaging Het
Crybg2 A G 4: 133,809,148 (GRCm39) S187G probably benign Het
Ddx1 A T 12: 13,286,096 (GRCm39) N285K probably benign Het
Dmxl2 A G 9: 54,387,664 (GRCm39) I58T probably damaging Het
Dock4 A G 12: 40,829,135 (GRCm39) Y1007C probably damaging Het
Eral1 C T 11: 77,966,559 (GRCm39) V234I possibly damaging Het
Fads2b C A 2: 85,319,149 (GRCm39) M384I possibly damaging Het
Fads2b T G 2: 85,319,157 (GRCm39) T382P probably damaging Het
Fam161b A G 12: 84,401,554 (GRCm39) F400S probably damaging Het
Fmnl3 T C 15: 99,223,754 (GRCm39) D314G probably damaging Het
Foxred2 A T 15: 77,839,909 (GRCm39) L127Q probably damaging Het
Gjd2 G A 2: 113,843,575 (GRCm39) A14V possibly damaging Het
Gon4l A G 3: 88,766,173 (GRCm39) probably null Het
Gpr151 T A 18: 42,711,985 (GRCm39) D231V probably benign Het
Gzf1 A T 2: 148,526,689 (GRCm39) K387* probably null Het
Hfm1 T A 5: 107,065,240 (GRCm39) K146N possibly damaging Het
Hgf G A 5: 16,809,920 (GRCm39) probably null Het
Isoc2b A G 7: 4,854,487 (GRCm39) S15P probably damaging Het
Itga5 A G 15: 103,265,970 (GRCm39) S126P probably damaging Het
Kat6b A G 14: 21,719,104 (GRCm39) D1152G probably benign Het
Kcna4 C T 2: 107,126,652 (GRCm39) S462F probably damaging Het
Kif24 A T 4: 41,394,168 (GRCm39) C902S probably benign Het
Lama2 A T 10: 27,204,068 (GRCm39) C523* probably null Het
Lama2 G C 10: 27,204,078 (GRCm39) S520* probably null Het
Ltf T C 9: 110,854,181 (GRCm39) V332A probably benign Het
Mapkap1 T C 2: 34,453,153 (GRCm39) F349L probably damaging Het
Mdm1 A G 10: 117,983,937 (GRCm39) N188D probably benign Het
Mfn1 T C 3: 32,631,252 (GRCm39) S730P possibly damaging Het
Mrgprd T A 7: 144,876,087 (GRCm39) D319E probably benign Het
Mrps9 C A 1: 42,944,573 (GRCm39) L364I probably damaging Het
Myo1h C T 5: 114,487,673 (GRCm39) R626C probably damaging Het
Nme3 T C 17: 25,115,829 (GRCm39) S61P probably benign Het
Or2g1 A G 17: 38,106,395 (GRCm39) Q20R probably benign Het
Or52e18 A G 7: 104,609,192 (GRCm39) I249T probably damaging Het
Pald1 A G 10: 61,184,311 (GRCm39) probably null Het
Papola A T 12: 105,775,950 (GRCm39) probably benign Het
Peg10 GAT GATCAT 6: 4,756,449 (GRCm39) probably benign Het
Plch1 T C 3: 63,605,504 (GRCm39) T1458A probably benign Het
Polr3e A G 7: 120,543,873 (GRCm39) Q659R probably damaging Het
Pramel38 C A 5: 94,365,978 (GRCm39) P32Q probably damaging Het
Shoc2 T C 19: 53,976,548 (GRCm39) V146A probably benign Het
Slc15a1 T C 14: 121,713,442 (GRCm39) T362A probably benign Het
Smpd3 A G 8: 106,991,300 (GRCm39) Y418H probably damaging Het
Sorcs1 A T 19: 50,213,557 (GRCm39) C723* probably null Het
Supt7l T A 5: 31,680,365 (GRCm39) N16Y probably damaging Het
Syngr2 T C 11: 117,703,499 (GRCm39) V105A probably damaging Het
Thrb T A 14: 17,981,899 (GRCm38) V8E probably benign Het
Tlx1 A T 19: 45,139,757 (GRCm39) I135F probably damaging Het
Tnfaip3 A G 10: 18,887,417 (GRCm39) I36T probably damaging Het
Troap A G 15: 98,980,569 (GRCm39) Y583C possibly damaging Het
Usp17lb T C 7: 104,490,307 (GRCm39) K207E probably benign Het
Wdr49 A T 3: 75,240,590 (GRCm39) probably null Het
Wdr64 G T 1: 175,533,634 (GRCm39) W90L probably damaging Het
Yme1l1 A G 2: 23,085,401 (GRCm39) E662G probably damaging Het
Zfp334 C T 2: 165,224,644 (GRCm39) V68I probably benign Het
Other mutations in Vmn2r10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00816:Vmn2r10 APN 5 109,150,451 (GRCm39) missense possibly damaging 0.75
IGL01618:Vmn2r10 APN 5 109,150,345 (GRCm39) missense probably damaging 1.00
IGL01624:Vmn2r10 APN 5 109,154,112 (GRCm39) missense possibly damaging 0.83
IGL01941:Vmn2r10 APN 5 109,143,820 (GRCm39) missense probably damaging 1.00
IGL01959:Vmn2r10 APN 5 109,145,571 (GRCm39) missense probably benign 0.00
IGL01973:Vmn2r10 APN 5 109,143,543 (GRCm39) missense probably damaging 1.00
IGL01985:Vmn2r10 APN 5 109,154,125 (GRCm39) missense probably benign 0.21
IGL02451:Vmn2r10 APN 5 109,143,788 (GRCm39) nonsense probably null
IGL02503:Vmn2r10 APN 5 109,151,341 (GRCm39) missense probably damaging 1.00
IGL03275:Vmn2r10 APN 5 109,151,243 (GRCm39) missense probably benign 0.00
R0035:Vmn2r10 UTSW 5 109,145,467 (GRCm39) splice site probably benign
R0395:Vmn2r10 UTSW 5 109,149,859 (GRCm39) missense probably damaging 1.00
R0454:Vmn2r10 UTSW 5 109,151,327 (GRCm39) missense probably benign 0.25
R0648:Vmn2r10 UTSW 5 109,143,782 (GRCm39) missense probably benign 0.00
R1251:Vmn2r10 UTSW 5 109,143,890 (GRCm39) missense probably benign 0.01
R1580:Vmn2r10 UTSW 5 109,154,117 (GRCm39) missense possibly damaging 0.82
R1845:Vmn2r10 UTSW 5 109,149,861 (GRCm39) nonsense probably null
R1986:Vmn2r10 UTSW 5 109,154,120 (GRCm39) nonsense probably null
R2137:Vmn2r10 UTSW 5 109,151,410 (GRCm39) missense possibly damaging 0.87
R2495:Vmn2r10 UTSW 5 109,143,961 (GRCm39) missense probably damaging 1.00
R3932:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R3933:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R4899:Vmn2r10 UTSW 5 109,151,324 (GRCm39) missense probably damaging 1.00
R4992:Vmn2r10 UTSW 5 109,145,592 (GRCm39) missense possibly damaging 0.89
R5124:Vmn2r10 UTSW 5 109,154,286 (GRCm39) missense probably benign 0.01
R5145:Vmn2r10 UTSW 5 109,143,761 (GRCm39) missense possibly damaging 0.64
R5156:Vmn2r10 UTSW 5 109,143,466 (GRCm39) missense probably benign 0.11
R5265:Vmn2r10 UTSW 5 109,143,586 (GRCm39) missense probably damaging 1.00
R5311:Vmn2r10 UTSW 5 109,154,121 (GRCm39) missense probably damaging 1.00
R5321:Vmn2r10 UTSW 5 109,143,505 (GRCm39) missense probably damaging 1.00
R5666:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5670:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5872:Vmn2r10 UTSW 5 109,151,377 (GRCm39) missense possibly damaging 0.84
R6004:Vmn2r10 UTSW 5 109,146,944 (GRCm39) missense probably benign 0.30
R6108:Vmn2r10 UTSW 5 109,143,667 (GRCm39) missense probably damaging 1.00
R6332:Vmn2r10 UTSW 5 109,151,328 (GRCm39) missense probably damaging 1.00
R6599:Vmn2r10 UTSW 5 109,143,944 (GRCm39) missense probably benign 0.09
R6651:Vmn2r10 UTSW 5 109,143,488 (GRCm39) missense probably null 0.22
R7023:Vmn2r10 UTSW 5 109,149,894 (GRCm39) missense probably damaging 0.96
R7146:Vmn2r10 UTSW 5 109,151,200 (GRCm39) missense probably damaging 1.00
R7941:Vmn2r10 UTSW 5 109,144,306 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r10 UTSW 5 109,149,955 (GRCm39) missense probably benign 0.00
R8478:Vmn2r10 UTSW 5 109,143,636 (GRCm39) missense probably damaging 1.00
R8526:Vmn2r10 UTSW 5 109,145,572 (GRCm39) missense possibly damaging 0.51
R8698:Vmn2r10 UTSW 5 109,151,390 (GRCm39) missense probably benign 0.00
R8796:Vmn2r10 UTSW 5 109,143,917 (GRCm39) missense possibly damaging 0.74
R8854:Vmn2r10 UTSW 5 109,144,126 (GRCm39) missense probably benign 0.20
R8871:Vmn2r10 UTSW 5 109,146,899 (GRCm39) missense possibly damaging 0.67
R8893:Vmn2r10 UTSW 5 109,143,677 (GRCm39) missense probably benign 0.09
R8907:Vmn2r10 UTSW 5 109,149,791 (GRCm39) missense probably benign
R8957:Vmn2r10 UTSW 5 109,149,780 (GRCm39) missense possibly damaging 0.60
R8976:Vmn2r10 UTSW 5 109,145,479 (GRCm39) missense probably damaging 1.00
R9155:Vmn2r10 UTSW 5 109,144,212 (GRCm39) missense probably benign 0.10
R9308:Vmn2r10 UTSW 5 109,145,476 (GRCm39) nonsense probably null
R9800:Vmn2r10 UTSW 5 109,150,404 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r10 UTSW 5 109,143,979 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r10 UTSW 5 109,149,854 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTATATGCCTCAGTACAGGGG -3'
(R):5'- ACATTTCTGAGTCTAGACTGGGG -3'

Sequencing Primer
(F):5'- TCAGTACAGGGGAGCACC -3'
(R):5'- AGACTGGGGTGGAATTATTTTAATTG -3'
Posted On 2018-10-18