Incidental Mutation 'R6815:Ccdc110'
ID 537282
Institutional Source Beutler Lab
Gene Symbol Ccdc110
Ensembl Gene ENSMUSG00000071104
Gene Name coiled-coil domain containing 110
Synonyms LOC212392
MMRRC Submission 044927-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R6815 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 46387656-46397182 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 46395024 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 305 (N305S)
Ref Sequence ENSEMBL: ENSMUSP00000092964 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095326] [ENSMUST00000174815]
AlphaFold Q3V125
Predicted Effect probably benign
Transcript: ENSMUST00000095326
AA Change: N305S

PolyPhen 2 Score 0.195 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000092964
Gene: ENSMUSG00000071104
AA Change: N305S

DomainStartEndE-ValueType
coiled coil region 442 794 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174815
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik T G 14: 54,828,610 (GRCm39) N297T probably damaging Het
6820408C15Rik A G 2: 152,282,975 (GRCm39) N251S probably benign Het
Abcc5 T C 16: 20,152,380 (GRCm39) T1389A probably damaging Het
Acad11 A G 9: 103,958,526 (GRCm39) T265A probably benign Het
Ace3 C T 11: 105,888,084 (GRCm39) Q302* probably null Het
Aip A T 19: 4,166,066 (GRCm39) H128Q probably benign Het
Akr1b7 A T 6: 34,389,269 (GRCm39) probably null Het
Arid4a T A 12: 71,063,856 (GRCm39) probably null Het
Armh1 T A 4: 117,087,134 (GRCm39) H177L probably damaging Het
Aspm A G 1: 139,407,880 (GRCm39) T2256A probably benign Het
Bco1 A T 8: 117,840,261 (GRCm39) M260L probably benign Het
Ccdc158 T A 5: 92,760,345 (GRCm39) Y1035F probably damaging Het
Cd180 C T 13: 102,841,937 (GRCm39) L328F probably damaging Het
Cntrl T C 2: 35,039,503 (GRCm39) L1121P probably damaging Het
Cyp2u1 A C 3: 131,091,659 (GRCm39) I287S probably damaging Het
Dnah3 C T 7: 119,570,950 (GRCm39) M2195I probably benign Het
Dnajc21 C T 15: 10,447,777 (GRCm39) probably null Het
Dock10 C T 1: 80,516,576 (GRCm39) V1398M possibly damaging Het
Dpy19l3 T A 7: 35,449,272 (GRCm39) I44F possibly damaging Het
Dst C A 1: 34,267,450 (GRCm39) T4964K possibly damaging Het
Ercc4 T C 16: 12,941,299 (GRCm39) I139T probably damaging Het
Gpr4 T A 7: 18,956,560 (GRCm39) F161I probably damaging Het
Gucy2e A C 11: 69,122,827 (GRCm39) L516R possibly damaging Het
Hdhd5 A G 6: 120,498,170 (GRCm39) V143A probably benign Het
Heatr4 T A 12: 84,026,501 (GRCm39) Q252L probably damaging Het
Heatr5a T G 12: 52,002,291 (GRCm39) D215A possibly damaging Het
Hipk2 G T 6: 38,795,777 (GRCm39) A164D probably damaging Het
Igsf11 A G 16: 38,829,243 (GRCm39) I46V probably benign Het
Iqgap1 C T 7: 80,416,632 (GRCm39) probably null Het
Lrig1 A G 6: 94,602,010 (GRCm39) L281P probably damaging Het
Or10p22 A G 10: 128,826,191 (GRCm39) S137G probably benign Het
Or7g32 G T 9: 19,389,061 (GRCm39) H159N probably benign Het
Pcdha7 A G 18: 37,108,174 (GRCm39) T400A probably damaging Het
Pde5a A G 3: 122,618,573 (GRCm39) T629A probably benign Het
Pkhd1l1 A G 15: 44,426,051 (GRCm39) D3204G probably damaging Het
Prkd2 T C 7: 16,577,718 (GRCm39) F57S probably benign Het
Prr15l T C 11: 96,825,433 (GRCm39) V21A probably damaging Het
Rag2 T A 2: 101,460,900 (GRCm39) N403K probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Rtl1 C A 12: 109,560,937 (GRCm39) D301Y probably damaging Het
Septin14 T C 5: 129,770,051 (GRCm39) N215S probably benign Het
Sin3a T A 9: 57,024,824 (GRCm39) D1061E probably benign Het
Skint5 T A 4: 113,574,324 (GRCm39) probably null Het
Stox2 A T 8: 47,646,136 (GRCm39) D441E probably damaging Het
Tmem52b G A 6: 129,493,705 (GRCm39) probably null Het
Tpm3-rs7 A G 14: 113,552,292 (GRCm39) E62G probably benign Het
Trim54 G T 5: 31,291,424 (GRCm39) V182L probably damaging Het
Trmt6 A C 2: 132,651,778 (GRCm39) V214G probably damaging Het
Ttc21b T C 2: 66,057,134 (GRCm39) S613G probably benign Het
Ttll4 C A 1: 74,718,508 (GRCm39) R120S possibly damaging Het
Wdr41 A T 13: 95,154,682 (GRCm39) K354N probably damaging Het
Zfp652 A T 11: 95,640,230 (GRCm39) K52* probably null Het
Other mutations in Ccdc110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01898:Ccdc110 APN 8 46,395,161 (GRCm39) missense possibly damaging 0.76
IGL02175:Ccdc110 APN 8 46,393,660 (GRCm39) missense probably benign 0.07
IGL02471:Ccdc110 APN 8 46,394,793 (GRCm39) missense probably benign 0.14
IGL02524:Ccdc110 APN 8 46,394,979 (GRCm39) missense probably benign
IGL02887:Ccdc110 APN 8 46,396,221 (GRCm39) missense probably benign 0.01
IGL03227:Ccdc110 APN 8 46,394,586 (GRCm39) missense probably damaging 1.00
IGL03238:Ccdc110 APN 8 46,394,859 (GRCm39) missense probably benign 0.00
droll UTSW 8 46,395,864 (GRCm39) missense probably benign 0.10
humorless UTSW 8 46,396,487 (GRCm39) missense probably benign 0.03
R0049:Ccdc110 UTSW 8 46,395,663 (GRCm39) missense probably damaging 1.00
R0049:Ccdc110 UTSW 8 46,395,663 (GRCm39) missense probably damaging 1.00
R0110:Ccdc110 UTSW 8 46,388,194 (GRCm39) missense probably benign 0.00
R0189:Ccdc110 UTSW 8 46,388,119 (GRCm39) missense probably damaging 0.98
R0218:Ccdc110 UTSW 8 46,387,761 (GRCm39) splice site probably benign
R0280:Ccdc110 UTSW 8 46,396,487 (GRCm39) missense probably benign 0.03
R0332:Ccdc110 UTSW 8 46,396,001 (GRCm39) nonsense probably null
R0371:Ccdc110 UTSW 8 46,395,843 (GRCm39) missense possibly damaging 0.86
R0469:Ccdc110 UTSW 8 46,388,194 (GRCm39) missense probably benign 0.00
R0502:Ccdc110 UTSW 8 46,387,761 (GRCm39) splice site probably benign
R0510:Ccdc110 UTSW 8 46,388,194 (GRCm39) missense probably benign 0.00
R0534:Ccdc110 UTSW 8 46,388,175 (GRCm39) missense possibly damaging 0.73
R0647:Ccdc110 UTSW 8 46,396,425 (GRCm39) missense probably damaging 0.99
R0714:Ccdc110 UTSW 8 46,396,047 (GRCm39) missense possibly damaging 0.71
R0721:Ccdc110 UTSW 8 46,395,026 (GRCm39) missense probably benign
R1029:Ccdc110 UTSW 8 46,394,817 (GRCm39) missense probably damaging 0.98
R1147:Ccdc110 UTSW 8 46,397,121 (GRCm39) missense possibly damaging 0.64
R1147:Ccdc110 UTSW 8 46,397,121 (GRCm39) missense possibly damaging 0.64
R1170:Ccdc110 UTSW 8 46,394,922 (GRCm39) missense probably benign 0.22
R1340:Ccdc110 UTSW 8 46,395,218 (GRCm39) missense probably benign 0.02
R1540:Ccdc110 UTSW 8 46,395,362 (GRCm39) nonsense probably null
R1587:Ccdc110 UTSW 8 46,394,783 (GRCm39) missense probably benign 0.01
R1602:Ccdc110 UTSW 8 46,391,955 (GRCm39) missense probably benign 0.12
R1629:Ccdc110 UTSW 8 46,395,164 (GRCm39) missense probably benign 0.08
R1842:Ccdc110 UTSW 8 46,393,605 (GRCm39) missense probably damaging 1.00
R1933:Ccdc110 UTSW 8 46,396,287 (GRCm39) missense probably damaging 1.00
R1934:Ccdc110 UTSW 8 46,396,287 (GRCm39) missense probably damaging 1.00
R2006:Ccdc110 UTSW 8 46,396,349 (GRCm39) missense probably damaging 1.00
R2043:Ccdc110 UTSW 8 46,395,864 (GRCm39) missense probably benign 0.10
R2093:Ccdc110 UTSW 8 46,395,114 (GRCm39) missense probably damaging 1.00
R2165:Ccdc110 UTSW 8 46,395,876 (GRCm39) missense probably benign 0.00
R3613:Ccdc110 UTSW 8 46,395,843 (GRCm39) missense possibly damaging 0.86
R3923:Ccdc110 UTSW 8 46,395,426 (GRCm39) missense probably damaging 1.00
R4648:Ccdc110 UTSW 8 46,395,705 (GRCm39) missense possibly damaging 0.95
R4773:Ccdc110 UTSW 8 46,396,245 (GRCm39) missense probably damaging 1.00
R4901:Ccdc110 UTSW 8 46,396,437 (GRCm39) missense probably benign 0.35
R4911:Ccdc110 UTSW 8 46,395,944 (GRCm39) missense probably benign 0.00
R4923:Ccdc110 UTSW 8 46,396,460 (GRCm39) missense probably benign 0.29
R5104:Ccdc110 UTSW 8 46,395,729 (GRCm39) missense probably damaging 0.99
R5561:Ccdc110 UTSW 8 46,393,646 (GRCm39) missense probably benign 0.02
R5966:Ccdc110 UTSW 8 46,395,573 (GRCm39) missense probably damaging 1.00
R5976:Ccdc110 UTSW 8 46,396,536 (GRCm39) missense possibly damaging 0.71
R6141:Ccdc110 UTSW 8 46,394,807 (GRCm39) missense possibly damaging 0.89
R6326:Ccdc110 UTSW 8 46,395,078 (GRCm39) missense probably damaging 1.00
R6366:Ccdc110 UTSW 8 46,396,425 (GRCm39) missense probably damaging 0.99
R6405:Ccdc110 UTSW 8 46,394,734 (GRCm39) nonsense probably null
R6482:Ccdc110 UTSW 8 46,395,825 (GRCm39) missense probably benign 0.00
R7387:Ccdc110 UTSW 8 46,395,233 (GRCm39) missense probably benign 0.00
R7680:Ccdc110 UTSW 8 46,394,688 (GRCm39) missense possibly damaging 0.64
R8099:Ccdc110 UTSW 8 46,395,130 (GRCm39) missense probably damaging 1.00
R8114:Ccdc110 UTSW 8 46,396,140 (GRCm39) missense probably damaging 1.00
R8151:Ccdc110 UTSW 8 46,395,830 (GRCm39) missense probably damaging 1.00
R8295:Ccdc110 UTSW 8 46,396,416 (GRCm39) missense probably damaging 0.97
R8532:Ccdc110 UTSW 8 46,396,032 (GRCm39) missense probably damaging 1.00
R9072:Ccdc110 UTSW 8 46,395,875 (GRCm39) missense probably benign 0.00
R9073:Ccdc110 UTSW 8 46,395,875 (GRCm39) missense probably benign 0.00
R9088:Ccdc110 UTSW 8 46,394,882 (GRCm39) missense probably damaging 0.99
R9803:Ccdc110 UTSW 8 46,395,626 (GRCm39) missense probably benign
X0053:Ccdc110 UTSW 8 46,395,998 (GRCm39) missense possibly damaging 0.56
X0054:Ccdc110 UTSW 8 46,394,880 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTAGACGACATCTGCCACTCG -3'
(R):5'- TCGGGAGTGGAACTTTAAATCC -3'

Sequencing Primer
(F):5'- TCTGCCACTCGATCAAGC -3'
(R):5'- AATCCATAATGTTCTTGCTGGTG -3'
Posted On 2018-10-18