Incidental Mutation 'R6819:Or10g3b'
ID 537534
Institutional Source Beutler Lab
Gene Symbol Or10g3b
Ensembl Gene ENSMUSG00000095030
Gene Name olfactory receptor family 10 subfamily G member 3B
Synonyms GA_x6K02T2RJGY-644134-645075, Olfr1513, MOR223-10, MOR223-7P
MMRRC Submission 044931-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R6819 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 52586560-52587501 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 52587156 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 116 (Y116H)
Ref Sequence ENSEMBL: ENSMUSP00000149216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089739] [ENSMUST00000215147]
AlphaFold L7N457
Predicted Effect probably damaging
Transcript: ENSMUST00000089739
AA Change: Y116H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000087171
Gene: ENSMUSG00000095030
AA Change: Y116H

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.2e-49 PFAM
Pfam:7tm_1 41 291 1.6e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215147
AA Change: Y116H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 C A 17: 24,506,767 (GRCm39) V1196L probably benign Het
Adal T A 2: 120,978,794 (GRCm39) I138N probably damaging Het
Arfgap1 T C 2: 180,613,478 (GRCm39) probably null Het
Boc T C 16: 44,313,188 (GRCm39) T559A probably damaging Het
Brip1 A G 11: 86,001,267 (GRCm39) V723A possibly damaging Het
Cnot10 A C 9: 114,444,123 (GRCm39) I424S probably benign Het
Cntnap4 T G 8: 113,529,858 (GRCm39) S689A probably benign Het
Cuzd1 A T 7: 130,911,460 (GRCm39) N506K possibly damaging Het
Dctn3 T A 4: 41,715,259 (GRCm39) T158S possibly damaging Het
Dnai2 A G 11: 114,635,917 (GRCm39) I301V probably benign Het
Ebpl G T 14: 61,578,695 (GRCm39) P180Q probably damaging Het
Epha5 T A 5: 84,254,649 (GRCm39) Y489F probably damaging Het
Frmd8 T C 19: 5,915,208 (GRCm39) N232S probably benign Het
Fuca1 T C 4: 135,660,267 (GRCm39) Y262H probably damaging Het
Gfy T C 7: 44,826,975 (GRCm39) I374V possibly damaging Het
Glg1 G A 8: 111,914,513 (GRCm39) R424C probably damaging Het
Ica1 G T 6: 8,742,288 (GRCm39) T115K probably damaging Het
Igf2bp2 T C 16: 21,879,586 (GRCm39) E511G probably damaging Het
Jag2 C A 12: 112,874,161 (GRCm39) R998L probably damaging Het
Kcnv1 G T 15: 44,972,513 (GRCm39) L457I probably damaging Het
Mroh2a C A 1: 88,170,142 (GRCm39) A685D possibly damaging Het
Ms4a8a T A 19: 11,053,743 (GRCm39) H121L probably damaging Het
Muc5b T A 7: 141,412,600 (GRCm39) S1849T unknown Het
Myo10 T C 15: 25,781,496 (GRCm39) V997A possibly damaging Het
Or10g9b T A 9: 39,917,844 (GRCm39) M134L probably benign Het
Or8g54 T A 9: 39,706,905 (GRCm39) I78N probably benign Het
Pate2 T A 9: 35,581,801 (GRCm39) C32S probably damaging Het
Per1 G T 11: 68,992,284 (GRCm39) Q179H probably damaging Het
Pierce1 TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC 2: 28,356,122 (GRCm39) probably benign Het
Rbp2 T A 9: 98,391,614 (GRCm39) V130E probably damaging Het
Rictor T A 15: 6,825,517 (GRCm39) probably null Het
Rundc3a A T 11: 102,289,287 (GRCm39) R153* probably null Het
Scrn3 C T 2: 73,149,826 (GRCm39) A174V probably damaging Het
Serpina10 T A 12: 103,594,619 (GRCm39) Q200L probably benign Het
Slc25a51 A T 4: 45,399,365 (GRCm39) I275N possibly damaging Het
Spast C T 17: 74,674,281 (GRCm39) H238Y possibly damaging Het
Speg A T 1: 75,368,456 (GRCm39) I775F possibly damaging Het
Ssh1 G T 5: 114,084,851 (GRCm39) T463K probably benign Het
Tm2d3 A G 7: 65,347,526 (GRCm39) E151G probably damaging Het
Uggt2 A G 14: 119,263,847 (GRCm39) I1061T probably damaging Het
Unc79 T G 12: 103,108,267 (GRCm39) S1941A probably benign Het
Vcan T C 13: 89,853,244 (GRCm39) D572G probably benign Het
Vmn2r16 T G 5: 109,488,412 (GRCm39) S428R probably benign Het
Zeb1 A G 18: 5,591,917 (GRCm39) D3G probably damaging Het
Zfp352 A G 4: 90,112,936 (GRCm39) T359A probably benign Het
Zfp987 C A 4: 146,062,315 (GRCm39) D582E probably benign Het
Zg16 G A 7: 126,649,692 (GRCm39) P90S possibly damaging Het
Other mutations in Or10g3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Or10g3b APN 14 52,587,167 (GRCm39) missense probably benign 0.00
IGL02485:Or10g3b APN 14 52,587,501 (GRCm39) start codon destroyed possibly damaging 0.89
IGL02828:Or10g3b APN 14 52,586,799 (GRCm39) missense probably benign 0.02
R0744:Or10g3b UTSW 14 52,586,835 (GRCm39) missense probably benign 0.00
R0833:Or10g3b UTSW 14 52,586,835 (GRCm39) missense probably benign 0.00
R2316:Or10g3b UTSW 14 52,587,395 (GRCm39) missense probably benign 0.00
R4898:Or10g3b UTSW 14 52,586,999 (GRCm39) missense probably damaging 1.00
R5018:Or10g3b UTSW 14 52,586,736 (GRCm39) missense possibly damaging 0.81
R5134:Or10g3b UTSW 14 52,587,248 (GRCm39) missense probably benign 0.03
R5485:Or10g3b UTSW 14 52,586,776 (GRCm39) nonsense probably null
R6877:Or10g3b UTSW 14 52,587,270 (GRCm39) missense possibly damaging 0.95
R7583:Or10g3b UTSW 14 52,587,360 (GRCm39) missense possibly damaging 0.93
R7606:Or10g3b UTSW 14 52,587,420 (GRCm39) missense probably benign 0.33
R7653:Or10g3b UTSW 14 52,586,889 (GRCm39) nonsense probably null
R8111:Or10g3b UTSW 14 52,587,344 (GRCm39) missense possibly damaging 0.70
R8262:Or10g3b UTSW 14 52,586,625 (GRCm39) missense probably damaging 1.00
R8487:Or10g3b UTSW 14 52,586,696 (GRCm39) missense probably damaging 1.00
R8786:Or10g3b UTSW 14 52,587,021 (GRCm39) missense possibly damaging 0.74
R9003:Or10g3b UTSW 14 52,586,768 (GRCm39) missense probably damaging 1.00
R9507:Or10g3b UTSW 14 52,586,678 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGATTGGGACCACAGTAGG -3'
(R):5'- GCTGGGGAACATGATCATCC -3'

Sequencing Primer
(F):5'- CCACAGTAGGGCAAGCG -3'
(R):5'- TGATCACCGTCTGCACCGAC -3'
Posted On 2018-10-18