Mutagenetix > Incidental Mutation

Incidental Mutation 'R6822:Kcnma1'

537687

Institutional Source

Beutler Lab

Gene Symbol

Kcnma1

Ensembl Gene

ENSMUSG00000063142

Gene Name

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Synonyms

MaxiK, BKCa, 5730414M22Rik, BK channel alpha subunit, Slo, Slo1, mSlo1

MMRRC Submission

044934-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.856) question?

Stock #

R6822 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

23342356-24055173 bp(-) (GRCm39)

Type of Mutation

splice site (4 bp from exon)

DNA Base Change (assembly)

T to C at 24053812 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000152959 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000145596] [ENSMUST00000188210] [ENSMUST00000188285] [ENSMUST00000188991] [ENSMUST00000190044] [ENSMUST00000190339] [ENSMUST00000190985] [ENSMUST00000223655] [ENSMUST00000223727] [ENSMUST00000223749] [ENSMUST00000224077] [ENSMUST00000224232] [ENSMUST00000224285] [ENSMUST00000224468] [ENSMUST00000224787] [ENSMUST00000224812] [ENSMUST00000225315] [ENSMUST00000225431] [ENSMUST00000225471] [ENSMUST00000225556] [ENSMUST00000225794] [ENSMUST00000226051]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000145596

Predicted Effect

probably null
Transcript: ENSMUST00000188210

SMART Domains

Protein: ENSMUSP00000141069
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	1.3e-18	PFAM
Pfam:Ion_trans_2	305	393	5.2e-16	PFAM
Pfam:TrkA_N	439	538	7.8e-7	PFAM
Pfam:BK_channel_a	536	634	5e-31	PFAM
low complexity region	988	996	N/A	INTRINSIC
low complexity region	1044	1055	N/A	INTRINSIC
low complexity region	1158	1184	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000188285

SMART Domains

Protein: ENSMUSP00000140275
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	1.3e-18	PFAM
Pfam:Ion_trans_2	305	393	5.4e-16	PFAM
Pfam:TrkA_N	439	538	8e-7	PFAM
Pfam:BK_channel_a	536	634	5.2e-31	PFAM
low complexity region	1019	1027	N/A	INTRINSIC
low complexity region	1075	1086	N/A	INTRINSIC
low complexity region	1189	1215	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000188991

SMART Domains

Protein: ENSMUSP00000140751
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	3.3e-18	PFAM
Pfam:Ion_trans_2	305	393	1.1e-15	PFAM
Pfam:TrkA_N	439	538	3.7e-7	PFAM
Pfam:BK_channel_a	536	634	3.4e-31	PFAM
low complexity region	1015	1023	N/A	INTRINSIC
low complexity region	1071	1082	N/A	INTRINSIC
low complexity region	1185	1211	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000190044

SMART Domains

Protein: ENSMUSP00000140033
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	1.3e-18	PFAM
Pfam:Ion_trans_2	305	393	5.1e-16	PFAM
Pfam:TrkA_N	439	538	7.5e-7	PFAM
Pfam:BK_channel_a	536	634	4.9e-31	PFAM
low complexity region	957	965	N/A	INTRINSIC
low complexity region	1013	1024	N/A	INTRINSIC
low complexity region	1127	1153	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000190339

SMART Domains

Protein: ENSMUSP00000141143
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190985

Predicted Effect

probably null
Transcript: ENSMUST00000223655

Predicted Effect

probably null
Transcript: ENSMUST00000223727

Predicted Effect

probably null
Transcript: ENSMUST00000223749

Predicted Effect

probably null
Transcript: ENSMUST00000224025

Predicted Effect

probably null
Transcript: ENSMUST00000224077

Predicted Effect

probably null
Transcript: ENSMUST00000224232

Predicted Effect

probably null
Transcript: ENSMUST00000224285

Predicted Effect

probably null
Transcript: ENSMUST00000224468

Predicted Effect

probably null
Transcript: ENSMUST00000224787

Predicted Effect

probably null
Transcript: ENSMUST00000224812

Predicted Effect

probably null
Transcript: ENSMUST00000225315

Predicted Effect

probably null
Transcript: ENSMUST00000225431

Predicted Effect

probably null
Transcript: ENSMUST00000225471

Predicted Effect

probably null
Transcript: ENSMUST00000225556

Predicted Effect

probably benign
Transcript: ENSMUST00000225794

Predicted Effect

probably benign
Transcript: ENSMUST00000226051

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

94% (46/49)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous inactivation of this gene leads to cerebellar ataxia, Purkinje cell dysfunction, uneven gait patterns, bladder hyperactivity, urinary incontinence, abnormal colonic K+ secretion, and hearing impairment. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam11	G	A	11: 102,667,501 (GRCm39)	R687Q	possibly damaging	Het
AI987944	A	G	7: 41,024,232 (GRCm39)	L249P	probably damaging	Het
Ankrd28	T	A	14: 31,458,797 (GRCm39)		probably null	Het
Bahcc1	T	C	11: 120,178,547 (GRCm39)	S2369P	probably damaging	Het
Birc6	T	C	17: 74,887,377 (GRCm39)	S902P	possibly damaging	Het
Birc6	A	T	17: 74,905,039 (GRCm39)	K1277N	probably damaging	Het
Brwd1	T	C	16: 95,842,474 (GRCm39)	E821G	probably benign	Het
Cct8l1	T	C	5: 25,722,937 (GRCm39)	S551P	possibly damaging	Het
Cmtm1	TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG	TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG	8: 105,036,334 (GRCm39)		probably null	Het
Cyp2c39	A	T	19: 39,525,261 (GRCm39)	D188V	probably damaging	Het
Dclk3	G	T	9: 111,268,405 (GRCm39)	A25S	probably benign	Het
Dpep2	A	T	8: 106,711,873 (GRCm39)	M518K	probably benign	Het
Dst	T	C	1: 34,314,755 (GRCm39)	V6462A	probably damaging	Het
Entpd3	T	C	9: 120,391,104 (GRCm39)		probably null	Het
Epm2aip1	T	C	9: 111,101,624 (GRCm39)	V199A	probably damaging	Het
Fam193b	A	G	13: 55,689,504 (GRCm39)		probably benign	Het
Fam50b	G	A	13: 34,931,084 (GRCm39)	E187K	possibly damaging	Het
Fat1	A	G	8: 45,479,441 (GRCm39)	D2829G	probably damaging	Het
Fcgbp	T	A	7: 27,806,781 (GRCm39)	Y2250N	probably damaging	Het
Gm40460	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	7: 141,794,450 (GRCm39)		probably benign	Het
Grik5	C	T	7: 24,745,780 (GRCm39)	R431Q	possibly damaging	Het
H2-Aa	C	T	17: 34,506,651 (GRCm39)		probably null	Het
Igsf9	T	A	1: 172,324,730 (GRCm39)	S883T	possibly damaging	Het
Kcnh7	T	G	2: 62,618,248 (GRCm39)	I414L	probably damaging	Het
Kcnmb1	T	C	11: 33,914,686 (GRCm39)		probably benign	Het
Kmt2d	A	G	15: 98,747,340 (GRCm39)		probably benign	Het
Krt9	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	11: 100,079,903 (GRCm39)		probably benign	Het
Map3k13	G	A	16: 21,741,013 (GRCm39)	S780N	probably benign	Het
Nlgn1	T	C	3: 26,187,796 (GRCm39)	T30A	probably benign	Het
Nucb1	A	G	7: 45,148,289 (GRCm39)	F175L	probably damaging	Het
Pax6	T	A	2: 105,516,268 (GRCm39)	V182E	probably benign	Het
Ptger1	A	G	8: 84,395,279 (GRCm39)	D252G	probably benign	Het
Rexo4	T	C	2: 26,850,283 (GRCm39)	D275G	probably damaging	Het
Ripk4	T	C	16: 97,547,236 (GRCm39)	D342G	probably damaging	Het
Rpl10l	A	T	12: 66,330,987 (GRCm39)	C49S	possibly damaging	Het
Sema7a	T	C	9: 57,867,619 (GRCm39)	F457S	probably damaging	Het
Shank3	G	A	15: 89,415,830 (GRCm39)	D155N	probably damaging	Het
Smpd3	G	A	8: 106,992,596 (GRCm39)		probably benign	Het
Smpd4	T	C	16: 17,458,097 (GRCm39)	V465A	probably damaging	Het
Sohlh2	T	C	3: 55,115,107 (GRCm39)	V364A	probably damaging	Het
Sos2	C	T	12: 69,697,423 (GRCm39)	R99Q	probably damaging	Het
Spry2	G	A	14: 106,130,791 (GRCm39)	Q132*	probably null	Het
Tbx19	G	T	1: 164,967,709 (GRCm39)	P346Q	probably damaging	Het
Tdrd6	A	G	17: 43,938,106 (GRCm39)	Y981H	probably damaging	Het
Tinag	T	C	9: 76,938,984 (GRCm39)	K165E	probably benign	Het
Tubb4a	A	T	17: 57,387,904 (GRCm39)	I374N	probably damaging	Het
Umodl1	C	T	17: 31,205,528 (GRCm39)	Q708*	probably null	Het
Vmn2r3	A	T	3: 64,194,876 (GRCm39)	V14E	probably benign	Het
Zfp82	G	A	7: 29,755,712 (GRCm39)	L457F	probably damaging	Het

Other mutations in Kcnma1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01318:Kcnma1	APN	14	23,364,390 (GRCm39)	splice site	probably benign
IGL01520:Kcnma1	APN	14	23,551,211 (GRCm39)	missense	possibly damaging	0.94
IGL01977:Kcnma1	APN	14	23,580,367 (GRCm39)	splice site	probably benign
IGL02140:Kcnma1	APN	14	23,359,113 (GRCm39)	missense	probably damaging	1.00
IGL02165:Kcnma1	APN	14	23,387,035 (GRCm39)	missense	possibly damaging	0.93
IGL02186:Kcnma1	APN	14	23,576,881 (GRCm39)	missense	probably benign	0.28
IGL02268:Kcnma1	APN	14	23,593,144 (GRCm39)	missense	probably damaging	1.00
IGL02353:Kcnma1	APN	14	23,641,681 (GRCm39)	missense	probably damaging	1.00
IGL02360:Kcnma1	APN	14	23,641,681 (GRCm39)	missense	probably damaging	1.00
IGL02491:Kcnma1	APN	14	23,361,757 (GRCm39)	missense	probably damaging	1.00
IGL02552:Kcnma1	APN	14	23,436,327 (GRCm39)	critical splice donor site	probably null
IGL02625:Kcnma1	APN	14	23,413,900 (GRCm39)	missense	probably damaging	1.00
IGL02677:Kcnma1	APN	14	23,513,224 (GRCm39)	missense	probably damaging	1.00
IGL02706:Kcnma1	APN	14	23,359,222 (GRCm39)	missense	probably damaging	1.00
G1citation:Kcnma1	UTSW	14	24,053,812 (GRCm39)	splice site	probably null
PIT4495001:Kcnma1	UTSW	14	23,475,665 (GRCm39)	missense	probably benign	0.00
PIT4514001:Kcnma1	UTSW	14	23,359,103 (GRCm39)	splice site	probably null
PIT4576001:Kcnma1	UTSW	14	23,359,103 (GRCm39)	splice site	probably null
R0071:Kcnma1	UTSW	14	23,576,835 (GRCm39)	missense	probably damaging	1.00
R0071:Kcnma1	UTSW	14	23,576,835 (GRCm39)	missense	probably damaging	1.00
R0115:Kcnma1	UTSW	14	23,364,243 (GRCm39)	missense	probably damaging	1.00
R0172:Kcnma1	UTSW	14	23,853,234 (GRCm39)	missense	probably damaging	1.00
R0178:Kcnma1	UTSW	14	23,576,835 (GRCm39)	missense	probably damaging	1.00
R0183:Kcnma1	UTSW	14	23,558,120 (GRCm39)	missense	probably damaging	1.00
R0240:Kcnma1	UTSW	14	23,544,647 (GRCm39)	missense	probably damaging	1.00
R0240:Kcnma1	UTSW	14	23,544,647 (GRCm39)	missense	probably damaging	1.00
R0328:Kcnma1	UTSW	14	23,423,265 (GRCm39)	missense	probably damaging	1.00
R0501:Kcnma1	UTSW	14	23,361,784 (GRCm39)	missense	possibly damaging	0.80
R0631:Kcnma1	UTSW	14	23,559,852 (GRCm39)	splice site	probably benign
R0668:Kcnma1	UTSW	14	23,417,563 (GRCm39)	missense	probably damaging	1.00
R0811:Kcnma1	UTSW	14	23,350,086 (GRCm39)	missense	probably damaging	0.96
R0812:Kcnma1	UTSW	14	23,350,086 (GRCm39)	missense	probably damaging	0.96
R1080:Kcnma1	UTSW	14	23,544,675 (GRCm39)	missense	probably damaging	1.00
R1419:Kcnma1	UTSW	14	23,417,710 (GRCm39)	missense	probably damaging	0.99
R1446:Kcnma1	UTSW	14	23,361,792 (GRCm39)	missense	probably damaging	1.00
R1454:Kcnma1	UTSW	14	23,513,268 (GRCm39)	missense	probably damaging	1.00
R1651:Kcnma1	UTSW	14	23,364,262 (GRCm39)	missense	probably damaging	1.00
R1826:Kcnma1	UTSW	14	23,380,997 (GRCm39)	missense	probably damaging	1.00
R1827:Kcnma1	UTSW	14	23,380,997 (GRCm39)	missense	probably damaging	1.00
R1828:Kcnma1	UTSW	14	23,380,997 (GRCm39)	missense	probably damaging	1.00
R1864:Kcnma1	UTSW	14	23,853,230 (GRCm39)	missense	probably damaging	1.00
R2002:Kcnma1	UTSW	14	23,387,097 (GRCm39)	missense	probably damaging	0.99
R2140:Kcnma1	UTSW	14	23,364,288 (GRCm39)	missense	probably damaging	1.00
R2278:Kcnma1	UTSW	14	23,593,151 (GRCm39)	nonsense	probably null
R2866:Kcnma1	UTSW	14	23,423,275 (GRCm39)	missense	probably benign	0.16
R2867:Kcnma1	UTSW	14	23,423,275 (GRCm39)	missense	probably benign	0.16
R2867:Kcnma1	UTSW	14	23,423,275 (GRCm39)	missense	probably benign	0.16
R2900:Kcnma1	UTSW	14	23,853,228 (GRCm39)	missense	probably damaging	1.00
R3820:Kcnma1	UTSW	14	23,350,006 (GRCm39)	missense	possibly damaging	0.66
R3821:Kcnma1	UTSW	14	23,417,679 (GRCm39)	missense	probably damaging	1.00
R3901:Kcnma1	UTSW	14	23,555,323 (GRCm39)	missense	probably damaging	0.98
R3975:Kcnma1	UTSW	14	24,053,815 (GRCm39)	critical splice donor site	probably null
R3976:Kcnma1	UTSW	14	24,053,815 (GRCm39)	critical splice donor site	probably null
R4352:Kcnma1	UTSW	14	23,361,720 (GRCm39)	missense	probably damaging	1.00
R4517:Kcnma1	UTSW	14	23,387,097 (GRCm39)	missense	probably damaging	1.00
R4598:Kcnma1	UTSW	14	23,853,228 (GRCm39)	missense	probably damaging	1.00
R4604:Kcnma1	UTSW	14	23,359,106 (GRCm39)	critical splice donor site	probably null
R4743:Kcnma1	UTSW	14	23,853,270 (GRCm39)	missense	probably damaging	1.00
R4754:Kcnma1	UTSW	14	23,413,904 (GRCm39)	missense	probably damaging	0.96
R4908:Kcnma1	UTSW	14	23,359,220 (GRCm39)	missense	probably damaging	0.99
R4960:Kcnma1	UTSW	14	24,054,186 (GRCm39)	intron	probably benign
R5175:Kcnma1	UTSW	14	23,386,106 (GRCm39)	critical splice donor site	probably null
R5218:Kcnma1	UTSW	14	23,513,253 (GRCm39)	missense	probably damaging	0.96
R5435:Kcnma1	UTSW	14	23,578,472 (GRCm39)	nonsense	probably null
R5705:Kcnma1	UTSW	14	24,053,839 (GRCm39)	missense	possibly damaging	0.73
R5746:Kcnma1	UTSW	14	23,544,635 (GRCm39)	missense	probably damaging	1.00
R5780:Kcnma1	UTSW	14	23,436,419 (GRCm39)	nonsense	probably null
R5793:Kcnma1	UTSW	14	23,359,103 (GRCm39)	splice site	probably null
R6039:Kcnma1	UTSW	14	23,359,105 (GRCm39)	missense	probably benign	0.42
R6039:Kcnma1	UTSW	14	23,359,105 (GRCm39)	missense	probably benign	0.42
R6133:Kcnma1	UTSW	14	24,053,936 (GRCm39)	missense	probably damaging	0.98
R6271:Kcnma1	UTSW	14	23,559,957 (GRCm39)	missense	probably damaging	1.00
R6490:Kcnma1	UTSW	14	23,386,165 (GRCm39)	missense	possibly damaging	0.46
R6704:Kcnma1	UTSW	14	24,052,882 (GRCm39)	nonsense	probably null
R6855:Kcnma1	UTSW	14	23,417,679 (GRCm39)	missense	probably damaging	1.00
R6920:Kcnma1	UTSW	14	23,576,602 (GRCm39)	critical splice donor site	probably null
R7017:Kcnma1	UTSW	14	23,544,711 (GRCm39)	missense	possibly damaging	0.79
R7081:Kcnma1	UTSW	14	23,350,086 (GRCm39)	missense	probably damaging	0.96
R7113:Kcnma1	UTSW	14	23,513,224 (GRCm39)	missense	probably damaging	1.00
R7131:Kcnma1	UTSW	14	23,417,562 (GRCm39)	missense	probably damaging	1.00
R7172:Kcnma1	UTSW	14	23,576,691 (GRCm39)	missense	probably damaging	1.00
R7207:Kcnma1	UTSW	14	23,359,083 (GRCm39)	makesense	probably null
R7308:Kcnma1	UTSW	14	23,381,003 (GRCm39)	missense	probably damaging	0.99
R7371:Kcnma1	UTSW	14	23,544,638 (GRCm39)	missense	possibly damaging	0.94
R7404:Kcnma1	UTSW	14	24,052,902 (GRCm39)	missense	unknown
R7560:Kcnma1	UTSW	14	23,580,310 (GRCm39)	missense	probably benign	0.15
R7693:Kcnma1	UTSW	14	23,417,680 (GRCm39)	missense	probably damaging	1.00
R7763:Kcnma1	UTSW	14	23,350,074 (GRCm39)	missense	possibly damaging	0.66
R7809:Kcnma1	UTSW	14	23,423,324 (GRCm39)	missense	probably benign	0.16
R7832:Kcnma1	UTSW	14	23,440,991 (GRCm39)	missense	probably benign
R7884:Kcnma1	UTSW	14	23,387,057 (GRCm39)	missense	probably benign	0.01
R8013:Kcnma1	UTSW	14	23,423,211 (GRCm39)	missense	probably benign	0.31
R8014:Kcnma1	UTSW	14	23,423,211 (GRCm39)	missense	probably benign	0.31
R8066:Kcnma1	UTSW	14	23,361,744 (GRCm39)	missense	probably benign	0.00
R8097:Kcnma1	UTSW	14	23,381,032 (GRCm39)	missense	probably damaging	1.00
R8154:Kcnma1	UTSW	14	23,361,822 (GRCm39)	missense	possibly damaging	0.62
R8507:Kcnma1	UTSW	14	23,641,706 (GRCm39)	missense	probably benign	0.00
R8672:Kcnma1	UTSW	14	23,551,230 (GRCm39)	missense	probably damaging	1.00
R8677:Kcnma1	UTSW	14	23,436,418 (GRCm39)	missense	probably benign	0.36
R8725:Kcnma1	UTSW	14	23,436,332 (GRCm39)	missense	probably benign	0.00
R8727:Kcnma1	UTSW	14	23,436,332 (GRCm39)	missense	probably benign	0.00
R8827:Kcnma1	UTSW	14	23,417,548 (GRCm39)	missense	probably damaging	1.00
R8880:Kcnma1	UTSW	14	23,417,718 (GRCm39)	missense	probably damaging	1.00
R8997:Kcnma1	UTSW	14	23,513,037 (GRCm39)	intron	probably benign
R9056:Kcnma1	UTSW	14	23,700,214 (GRCm39)	missense	possibly damaging	0.80
R9346:Kcnma1	UTSW	14	23,700,233 (GRCm39)	missense	possibly damaging	0.94
R9403:Kcnma1	UTSW	14	23,593,145 (GRCm39)	missense	probably benign	0.05
R9438:Kcnma1	UTSW	14	23,417,653 (GRCm39)	missense	probably benign	0.00
R9482:Kcnma1	UTSW	14	23,441,033 (GRCm39)	missense	probably benign
R9511:Kcnma1	UTSW	14	23,361,793 (GRCm39)	missense	possibly damaging	0.90
R9649:Kcnma1	UTSW	14	23,501,666 (GRCm39)	critical splice donor site	probably null
R9663:Kcnma1	UTSW	14	24,053,897 (GRCm39)	missense	probably benign	0.15
R9673:Kcnma1	UTSW	14	23,558,123 (GRCm39)	missense	probably benign	0.01
RF001:Kcnma1	UTSW	14	23,361,765 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CGGCCATAGTCACCAATAGC -3'
(R):5'- TCATCATACCGGTGACCATG -3'

Sequencing Primer
(F):5'- TGCTGGGGTCAACTCCTCAC -3'
(R):5'- ATGGAGGTGCCGTGCGAC -3'

Posted On

2018-10-18