Incidental Mutation 'IGL01020:Olfr938'
ID53778
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr938
Ensembl Gene ENSMUSG00000048501
Gene Nameolfactory receptor 938
SynonymsGA_x6K02T2PVTD-32774646-32773699, MOR171-25
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #IGL01020
Quality Score
Status
Chromosome9
Chromosomal Location39077698-39078887 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 39078451 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Arginine at position 98 (I98R)
Ref Sequence ENSEMBL: ENSMUSP00000055053 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056499]
Predicted Effect probably damaging
Transcript: ENSMUST00000056499
AA Change: I98R

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: I98R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8e-49 PFAM
Pfam:7tm_1 41 290 5.5e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175411
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215888
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt3 T G 1: 177,130,967 probably benign Het
Aldh18a1 C T 19: 40,569,181 probably benign Het
Arhgap32 A G 9: 32,257,361 H880R probably benign Het
Arhgef7 G A 8: 11,782,540 S5N probably damaging Het
Atp6v1e1 T C 6: 120,808,411 M40V possibly damaging Het
Atr T C 9: 95,862,783 V51A probably damaging Het
Atxn10 A G 15: 85,375,422 probably null Het
Btbd16 T A 7: 130,824,361 I502N probably damaging Het
Casc4 G A 2: 121,925,722 V411I probably benign Het
Celsr2 G T 3: 108,403,270 L1499M probably damaging Het
Cfl1 C T 19: 5,493,681 probably benign Het
Cul9 T C 17: 46,539,023 E500G probably damaging Het
Dusp3 G T 11: 101,984,644 N31K probably benign Het
Erbb4 A T 1: 68,298,449 probably benign Het
Fam234b G A 6: 135,211,906 V170M probably benign Het
Fign A G 2: 63,979,010 S639P probably damaging Het
Gbp7 A G 3: 142,542,857 T294A probably benign Het
Ift80 C T 3: 68,963,679 D195N probably damaging Het
Kif21b G T 1: 136,154,094 probably benign Het
Kif2c A T 4: 117,166,904 F397I probably damaging Het
Lamc3 T C 2: 31,914,656 V567A probably benign Het
Letmd1 T C 15: 100,471,759 M36T probably damaging Het
Lrp1b A G 2: 40,998,247 W2220R probably damaging Het
Mical2 T A 7: 112,315,076 probably benign Het
Mtif2 A G 11: 29,544,973 D691G possibly damaging Het
Myh8 G A 11: 67,283,403 V189M probably damaging Het
Myo9b G A 8: 71,352,000 R1418K probably benign Het
Nkpd1 G A 7: 19,518,749 V7M possibly damaging Het
Nrxn2 G A 19: 6,493,443 V1116I probably benign Het
Nynrin A G 14: 55,868,448 M875V probably benign Het
Oat T C 7: 132,567,173 probably null Het
Olfr855 G A 9: 19,585,320 S261N possibly damaging Het
Prkaa2 C T 4: 105,075,462 R63Q probably damaging Het
Psg29 T A 7: 17,208,732 S219R probably benign Het
Ptprc T C 1: 138,120,173 probably null Het
Pwwp2b G T 7: 139,254,855 E71* probably null Het
Robo2 T C 16: 73,928,151 T1055A probably benign Het
Serpina9 T A 12: 104,008,586 N103Y probably damaging Het
Sis T C 3: 72,966,838 E10G probably damaging Het
Tbck C T 3: 132,727,142 Q438* probably null Het
Thnsl1 T C 2: 21,212,494 L353S probably damaging Het
Tmem237 C A 1: 59,107,453 probably null Het
Tuba3a C T 6: 125,281,340 R229H probably damaging Het
Zbtb2 A G 10: 4,369,702 I108T probably benign Het
Zfp345 T C 2: 150,473,047 N190S possibly damaging Het
Other mutations in Olfr938
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01298:Olfr938 APN 9 39078724 missense possibly damaging 0.63
IGL02930:Olfr938 APN 9 39078012 missense probably damaging 1.00
IGL03346:Olfr938 APN 9 39077962 missense probably damaging 0.99
IGL03346:Olfr938 APN 9 39077961 missense probably benign 0.35
IGL03399:Olfr938 APN 9 39078237 nonsense probably null
R0536:Olfr938 UTSW 9 39078329 missense probably benign 0.03
R1170:Olfr938 UTSW 9 39078229 missense possibly damaging 0.50
R1951:Olfr938 UTSW 9 39078284 missense probably benign 0.07
R1952:Olfr938 UTSW 9 39078284 missense probably benign 0.07
R2066:Olfr938 UTSW 9 39078214 missense probably damaging 1.00
R2906:Olfr938 UTSW 9 39078373 missense probably benign 0.39
R4707:Olfr938 UTSW 9 39078262 missense probably benign 0.00
R4767:Olfr938 UTSW 9 39078692 missense possibly damaging 0.71
R4951:Olfr938 UTSW 9 39078259 missense probably benign 0.10
R5888:Olfr938 UTSW 9 39077967 nonsense probably null
R5905:Olfr938 UTSW 9 39078083 missense probably damaging 1.00
R6028:Olfr938 UTSW 9 39078083 missense probably damaging 1.00
R6329:Olfr938 UTSW 9 39077903 missense probably benign 0.02
R7240:Olfr938 UTSW 9 39078610 missense probably damaging 0.99
R7345:Olfr938 UTSW 9 39078334 missense probably damaging 1.00
R8058:Olfr938 UTSW 9 39078566 missense probably damaging 1.00
X0062:Olfr938 UTSW 9 39078466 missense probably benign 0.15
Posted On2013-06-28