Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01020:Or8g24'

53778

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8g24

Ensembl Gene

ENSMUSG00000048501

Gene Name

olfactory receptor family 8 subfamily G member 24

Synonyms

MOR171-25, Olfr938, GA_x6K02T2PVTD-32774646-32773699

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL01020

Quality Score

Status

Chromosome

Chromosomal Location

38989092-38990039 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 38989747 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Arginine at position 98 (I98R)

Ref Sequence

ENSEMBL: ENSMUSP00000055053 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056499]

AlphaFold

Q9EQ93

Predicted Effect

probably damaging
Transcript: ENSMUST00000056499
AA Change: I98R

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: I98R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8e-49	PFAM
Pfam:7tm_1	41	290	5.5e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175411

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215888

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akt3	T	G	1: 176,958,533 (GRCm39)		probably benign	Het
Aldh18a1	C	T	19: 40,557,625 (GRCm39)		probably benign	Het
Arhgap32	A	G	9: 32,168,657 (GRCm39)	H880R	probably benign	Het
Arhgef7	G	A	8: 11,832,540 (GRCm39)	S5N	probably damaging	Het
Atp6v1e1	T	C	6: 120,785,372 (GRCm39)	M40V	possibly damaging	Het
Atr	T	C	9: 95,744,836 (GRCm39)	V51A	probably damaging	Het
Atxn10	A	G	15: 85,259,623 (GRCm39)		probably null	Het
Btbd16	T	A	7: 130,426,091 (GRCm39)	I502N	probably damaging	Het
Celsr2	G	T	3: 108,310,586 (GRCm39)	L1499M	probably damaging	Het
Cfl1	C	T	19: 5,543,709 (GRCm39)		probably benign	Het
Cul9	T	C	17: 46,849,949 (GRCm39)	E500G	probably damaging	Het
Dusp3	G	T	11: 101,875,470 (GRCm39)	N31K	probably benign	Het
Erbb4	A	T	1: 68,337,608 (GRCm39)		probably benign	Het
Fam234b	G	A	6: 135,188,904 (GRCm39)	V170M	probably benign	Het
Fign	A	G	2: 63,809,354 (GRCm39)	S639P	probably damaging	Het
Gbp7	A	G	3: 142,248,618 (GRCm39)	T294A	probably benign	Het
Golm2	G	A	2: 121,756,203 (GRCm39)	V411I	probably benign	Het
Ift80	C	T	3: 68,871,012 (GRCm39)	D195N	probably damaging	Het
Kif21b	G	T	1: 136,081,832 (GRCm39)		probably benign	Het
Kif2c	A	T	4: 117,024,101 (GRCm39)	F397I	probably damaging	Het
Lamc3	T	C	2: 31,804,668 (GRCm39)	V567A	probably benign	Het
Letmd1	T	C	15: 100,369,640 (GRCm39)	M36T	probably damaging	Het
Lrp1b	A	G	2: 40,888,259 (GRCm39)	W2220R	probably damaging	Het
Mical2	T	A	7: 111,914,283 (GRCm39)		probably benign	Het
Mtif2	A	G	11: 29,494,973 (GRCm39)	D691G	possibly damaging	Het
Myh8	G	A	11: 67,174,229 (GRCm39)	V189M	probably damaging	Het
Myo9b	G	A	8: 71,804,644 (GRCm39)	R1418K	probably benign	Het
Nkpd1	G	A	7: 19,252,674 (GRCm39)	V7M	possibly damaging	Het
Nrxn2	G	A	19: 6,543,473 (GRCm39)	V1116I	probably benign	Het
Nynrin	A	G	14: 56,105,905 (GRCm39)	M875V	probably benign	Het
Oat	T	C	7: 132,168,902 (GRCm39)		probably null	Het
Or7g35	G	A	9: 19,496,616 (GRCm39)	S261N	possibly damaging	Het
Prkaa2	C	T	4: 104,932,659 (GRCm39)	R63Q	probably damaging	Het
Psg29	T	A	7: 16,942,657 (GRCm39)	S219R	probably benign	Het
Ptprc	T	C	1: 138,047,911 (GRCm39)		probably null	Het
Pwwp2b	G	T	7: 138,834,771 (GRCm39)	E71*	probably null	Het
Robo2	T	C	16: 73,725,039 (GRCm39)	T1055A	probably benign	Het
Serpina9	T	A	12: 103,974,845 (GRCm39)	N103Y	probably damaging	Het
Sis	T	C	3: 72,874,171 (GRCm39)	E10G	probably damaging	Het
Tbck	C	T	3: 132,432,903 (GRCm39)	Q438*	probably null	Het
Thnsl1	T	C	2: 21,217,305 (GRCm39)	L353S	probably damaging	Het
Tmem237	C	A	1: 59,146,612 (GRCm39)		probably null	Het
Tuba3a	C	T	6: 125,258,303 (GRCm39)	R229H	probably damaging	Het
Zbtb2	A	G	10: 4,319,702 (GRCm39)	I108T	probably benign	Het
Zfp345	T	C	2: 150,314,967 (GRCm39)	N190S	possibly damaging	Het

Other mutations in Or8g24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01298:Or8g24	APN	9	38,990,020 (GRCm39)	missense	possibly damaging	0.63
IGL02930:Or8g24	APN	9	38,989,308 (GRCm39)	missense	probably damaging	1.00
IGL03346:Or8g24	APN	9	38,989,257 (GRCm39)	missense	probably benign	0.35
IGL03346:Or8g24	APN	9	38,989,258 (GRCm39)	missense	probably damaging	0.99
IGL03399:Or8g24	APN	9	38,989,533 (GRCm39)	nonsense	probably null
R0536:Or8g24	UTSW	9	38,989,625 (GRCm39)	missense	probably benign	0.03
R1170:Or8g24	UTSW	9	38,989,525 (GRCm39)	missense	possibly damaging	0.50
R1951:Or8g24	UTSW	9	38,989,580 (GRCm39)	missense	probably benign	0.07
R1952:Or8g24	UTSW	9	38,989,580 (GRCm39)	missense	probably benign	0.07
R2066:Or8g24	UTSW	9	38,989,510 (GRCm39)	missense	probably damaging	1.00
R2906:Or8g24	UTSW	9	38,989,669 (GRCm39)	missense	probably benign	0.39
R4707:Or8g24	UTSW	9	38,989,558 (GRCm39)	missense	probably benign	0.00
R4767:Or8g24	UTSW	9	38,989,988 (GRCm39)	missense	possibly damaging	0.71
R4951:Or8g24	UTSW	9	38,989,555 (GRCm39)	missense	probably benign	0.10
R5888:Or8g24	UTSW	9	38,989,263 (GRCm39)	nonsense	probably null
R5905:Or8g24	UTSW	9	38,989,379 (GRCm39)	missense	probably damaging	1.00
R6028:Or8g24	UTSW	9	38,989,379 (GRCm39)	missense	probably damaging	1.00
R6329:Or8g24	UTSW	9	38,989,199 (GRCm39)	missense	probably benign	0.02
R7240:Or8g24	UTSW	9	38,989,906 (GRCm39)	missense	probably damaging	0.99
R7345:Or8g24	UTSW	9	38,989,630 (GRCm39)	missense	probably damaging	1.00
R8058:Or8g24	UTSW	9	38,989,862 (GRCm39)	missense	probably damaging	1.00
R9023:Or8g24	UTSW	9	38,989,307 (GRCm39)	missense	probably benign	0.09
R9547:Or8g24	UTSW	9	38,989,927 (GRCm39)	missense	probably damaging	0.99
R9682:Or8g24	UTSW	9	38,989,874 (GRCm39)	missense	possibly damaging	0.95
R9760:Or8g24	UTSW	9	38,989,271 (GRCm39)	missense	possibly damaging	0.95
X0062:Or8g24	UTSW	9	38,989,762 (GRCm39)	missense	probably benign	0.15

Posted On

2013-06-28