|List |< first << previous [record 19 of 43] next >> last >||
|Institutional Source||Beutler Lab|
|Gene Name||interleukin 18 receptor accessory protein|
|Synonyms||AcPL accessory protein-like)|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6859 (G1)|
|Chromosomal Location||40515362-40551705 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 40525095 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 124 (Y124*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027237 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027237]|
|Predicted Effect||probably null
AA Change: Y124*
AA Change: Y124*
|Coding Region Coverage||
|Validation Efficiency||100% (42/42)|
FUNCTION: Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]
PHENOTYPE: Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il18rap||
(F):5'- TGCTCACAAACCTTGCAGTGG -3'
(R):5'- AATGGAGCCAGTACTGCCAAG -3'
(F):5'- GCAGTGGCAGTCAGAAGG -3'
(R):5'- CTGCCAAGAAGTAGGACTTGTTC -3'