Incidental Mutation 'R6837:Tmem161b'
ID 537912
Institutional Source Beutler Lab
Gene Symbol Tmem161b
Ensembl Gene ENSMUSG00000035762
Gene Name transmembrane protein 161B
Synonyms 2810446P07Rik
MMRRC Submission 044945-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6837 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 84370415-84444085 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) C to A at 84370537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152891 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057495] [ENSMUST00000223827] [ENSMUST00000223862] [ENSMUST00000225069] [ENSMUST00000224525]
AlphaFold Q8C2L6
Predicted Effect probably benign
Transcript: ENSMUST00000057495
AA Change: -1
SMART Domains Protein: ENSMUSP00000055208
Gene: ENSMUSG00000035762
AA Change: -1

DomainStartEndE-ValueType
Pfam:Tmemb_161AB 2 485 1.3e-213 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180894
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185973
Predicted Effect probably benign
Transcript: ENSMUST00000223827
Predicted Effect probably benign
Transcript: ENSMUST00000223862
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224501
Predicted Effect probably benign
Transcript: ENSMUST00000225069
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225126
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225212
Predicted Effect probably benign
Transcript: ENSMUST00000224525
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 98% (41/42)
MGI Phenotype PHENOTYPE: Homozygous mice exhibit lethality before genotyping age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 G A 12: 53,188,045 (GRCm39) E1820K probably damaging Het
Anxa8 A T 14: 33,814,511 (GRCm39) I116F probably damaging Het
Arid4a A G 12: 71,122,289 (GRCm39) D890G probably benign Het
Aup1 C T 6: 83,034,279 (GRCm39) T396I possibly damaging Het
C2cd3 G C 7: 100,097,953 (GRCm39) E594Q probably damaging Het
Colgalt2 C T 1: 152,382,579 (GRCm39) P477L probably damaging Het
Dennd3 G A 15: 73,429,542 (GRCm39) D20N probably damaging Het
Dpysl3 A G 18: 43,570,947 (GRCm39) I109T probably benign Het
Fas A T 19: 34,284,564 (GRCm39) T24S probably damaging Het
Fras1 A T 5: 96,874,832 (GRCm39) I2332F probably damaging Het
Gm10267 T C 18: 44,291,375 (GRCm39) H32R probably benign Het
Gm57859 A G 11: 113,579,439 (GRCm39) H278R possibly damaging Het
Hcfc2 A T 10: 82,575,030 (GRCm39) I230F probably damaging Het
Hdac9 T C 12: 34,337,463 (GRCm39) T673A probably benign Het
Herc2 T G 7: 55,839,589 (GRCm39) N3366K possibly damaging Het
Hhla1 T C 15: 65,820,334 (GRCm39) N139D probably damaging Het
Hip1r A G 5: 124,136,928 (GRCm39) E632G possibly damaging Het
Kcnc2 A G 10: 112,294,407 (GRCm39) D98G probably damaging Het
Maip1 T A 1: 57,454,891 (GRCm39) *292K probably null Het
Map2 T C 1: 66,453,731 (GRCm39) F874L probably damaging Het
Myof A T 19: 37,911,404 (GRCm39) probably null Het
Notch2 A G 3: 97,978,170 (GRCm39) probably null Het
Npy5r T A 8: 67,134,392 (GRCm39) M134L probably benign Het
Ntsr2 T A 12: 16,709,710 (GRCm39) M225K probably benign Het
Nup153 G A 13: 46,847,527 (GRCm39) T634I probably damaging Het
Or51f1d T A 7: 102,700,929 (GRCm39) Y141* probably null Het
Pcsk5 T C 19: 17,416,448 (GRCm39) S1667G probably benign Het
Pex13 A G 11: 23,599,527 (GRCm39) I328T possibly damaging Het
Pkd2 T G 5: 104,624,909 (GRCm39) L235W probably damaging Het
Prune2 A T 19: 17,156,292 (GRCm39) D66V probably damaging Het
Rasal3 T C 17: 32,622,044 (GRCm39) N105S probably benign Het
Sla A T 15: 66,658,939 (GRCm39) I144N probably damaging Het
Slc5a4b A T 10: 75,898,220 (GRCm39) I498N possibly damaging Het
Snx14 C T 9: 88,262,276 (GRCm39) E872K probably benign Het
Stx16 G A 2: 173,935,795 (GRCm39) R242H probably benign Het
Tg T C 15: 66,567,984 (GRCm39) F1296S probably damaging Het
Tmf1 G A 6: 97,153,542 (GRCm39) T177M possibly damaging Het
Tuba4a T C 1: 75,194,038 (GRCm39) Q14R probably damaging Het
Vmn2r114 T C 17: 23,529,176 (GRCm39) M309V probably benign Het
Vps13c C T 9: 67,817,504 (GRCm39) P1059S probably benign Het
Yars1 T A 4: 129,103,544 (GRCm39) S298T possibly damaging Het
Other mutations in Tmem161b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00666:Tmem161b APN 13 84,442,715 (GRCm39) splice site probably benign
IGL01086:Tmem161b APN 13 84,370,541 (GRCm39) utr 5 prime probably benign
IGL01150:Tmem161b APN 13 84,440,526 (GRCm39) nonsense probably null
IGL01566:Tmem161b APN 13 84,442,881 (GRCm39) missense probably benign 0.35
IGL02183:Tmem161b APN 13 84,420,373 (GRCm39) missense probably damaging 1.00
IGL02481:Tmem161b APN 13 84,432,112 (GRCm39) missense probably damaging 0.99
IGL02519:Tmem161b APN 13 84,442,863 (GRCm39) missense probably damaging 1.00
IGL03207:Tmem161b APN 13 84,442,714 (GRCm39) splice site probably benign
R6836_Tmem161b_587 UTSW 13 84,370,537 (GRCm39) start gained probably benign
R0015:Tmem161b UTSW 13 84,370,533 (GRCm39) splice site probably null
R0376:Tmem161b UTSW 13 84,440,502 (GRCm39) missense probably benign 0.43
R0613:Tmem161b UTSW 13 84,399,439 (GRCm39) missense probably damaging 1.00
R1925:Tmem161b UTSW 13 84,408,348 (GRCm39) missense probably benign 0.07
R1935:Tmem161b UTSW 13 84,441,585 (GRCm39) missense probably damaging 1.00
R1936:Tmem161b UTSW 13 84,441,585 (GRCm39) missense probably damaging 1.00
R2325:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R2988:Tmem161b UTSW 13 84,440,574 (GRCm39) nonsense probably null
R4327:Tmem161b UTSW 13 84,399,359 (GRCm39) missense probably damaging 1.00
R4525:Tmem161b UTSW 13 84,405,921 (GRCm39) missense probably benign 0.00
R4558:Tmem161b UTSW 13 84,399,363 (GRCm39) missense possibly damaging 0.50
R5133:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R5134:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R5727:Tmem161b UTSW 13 84,434,909 (GRCm39) missense possibly damaging 0.63
R5875:Tmem161b UTSW 13 84,442,977 (GRCm39) missense probably damaging 1.00
R6217:Tmem161b UTSW 13 84,399,363 (GRCm39) missense possibly damaging 0.50
R6527:Tmem161b UTSW 13 84,420,383 (GRCm39) missense probably benign 0.06
R6550:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6551:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6553:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6554:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6640:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6641:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6685:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6836:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6838:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7077:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7078:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7386:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7388:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7429:Tmem161b UTSW 13 84,430,866 (GRCm39) critical splice acceptor site probably null
R7430:Tmem161b UTSW 13 84,430,866 (GRCm39) critical splice acceptor site probably null
R7547:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7548:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7634:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7636:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8094:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8095:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8255:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8257:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8669:Tmem161b UTSW 13 84,420,288 (GRCm39) critical splice acceptor site probably null
R9049:Tmem161b UTSW 13 84,442,754 (GRCm39) missense probably benign
R9092:Tmem161b UTSW 13 84,440,503 (GRCm39) missense possibly damaging 0.69
R9316:Tmem161b UTSW 13 84,430,855 (GRCm39) missense possibly damaging 0.84
R9326:Tmem161b UTSW 13 84,440,602 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGCTTTAGAGAACGCCTTGC -3'
(R):5'- TAGACTGGGTACTCCGACAGAC -3'

Sequencing Primer
(F):5'- TCCTCTCTGCGTGGCGTG -3'
(R):5'- TCCCTCGGCTGTCTGGAAC -3'
Posted On 2018-10-18