|Institutional Source||Beutler Lab|
|Gene Name||mitogen-activated protein kinase 13|
|Synonyms||p38 delta MAP kinase, SAPK4, Serk4|
|Is this an essential gene?||Possibly non essential (E-score: 0.266)|
|Stock #||R6838 (G1)|
|Chromosomal Location||28769307-28778698 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||G to T at 28777561 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000004986 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000004986] [ENSMUST00000129096]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||97% (64/66)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin secretion, decreased blood glucose, and decreased susceptibility to diet- or chemically-induced diabetes. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mapk13||
(F):5'- AAGTAGCCTCCTTCTGACCTGG -3'
(R):5'- AGGATTTGGCCTGGAAGAC -3'
(F):5'- AAGAGCCTGCCGTGGTTAG -3'
(R):5'- ACAGAAAAATATGGAATGTCTTCAGG -3'