Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01013:Ccdc162'

53806

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccdc162

Ensembl Gene

ENSMUSG00000075225

Gene Name

coiled-coil domain containing 162

Synonyms

5033413D22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01013

Quality Score

Status

Chromosome

Chromosomal Location

41538846-41716634 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 41581339 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 1534 (P1534L)

Ref Sequence

ENSEMBL: ENSMUSP00000140774 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019955] [ENSMUST00000099932] [ENSMUST00000179614] [ENSMUST00000189488] [ENSMUST00000219054]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000019955

SMART Domains

Protein: ENSMUSP00000019955
Gene: ENSMUSG00000075225

Domain	Start	End	E-Value	Type
coiled coil region	1	37	N/A	INTRINSIC
low complexity region	116	138	N/A	INTRINSIC
coiled coil region	177	217	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000095227

SMART Domains

Protein: ENSMUSP00000092852
Gene: ENSMUSG00000075225

Domain	Start	End	E-Value	Type
coiled coil region	140	179	N/A	INTRINSIC
low complexity region	304	326	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000099932
AA Change: P71L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000097516
Gene: ENSMUSG00000075225
AA Change: P71L

Domain	Start	End	E-Value	Type
coiled coil region	327	366	N/A	INTRINSIC
low complexity region	490	512	N/A	INTRINSIC
coiled coil region	551	607	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160751

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000165647

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170047

Predicted Effect

probably benign
Transcript: ENSMUST00000179614
AA Change: P261L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000135966
Gene: ENSMUSG00000075225
AA Change: P261L

Domain	Start	End	E-Value	Type
coiled coil region	517	556	N/A	INTRINSIC
low complexity region	680	702	N/A	INTRINSIC
coiled coil region	741	797	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000189488
AA Change: P1534L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000140774
Gene: ENSMUSG00000075225
AA Change: P1534L

Domain	Start	End	E-Value	Type
low complexity region	328	347	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000219054
AA Change: P261L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	T	A	5: 76,886,206 (GRCm38)	E499D	possibly damaging	Het
Abca1	A	T	4: 53,038,185 (GRCm38)	L2059*	probably null	Het
Ankar	T	A	1: 72,650,989 (GRCm38)	I1228F	possibly damaging	Het
Appl1	A	T	14: 26,949,476 (GRCm38)	Y340N	possibly damaging	Het
Atp8b4	C	A	2: 126,323,087 (GRCm38)	R1103L	probably benign	Het
B4galt6	A	G	18: 20,689,013 (GRCm38)	V308A	probably damaging	Het
Ccdc78	A	G	17: 25,789,054 (GRCm38)	E313G	possibly damaging	Het
Cep57l1	G	A	10: 41,740,869 (GRCm38)	R141*	probably null	Het
Cpsf1	G	A	15: 76,599,297 (GRCm38)	Q883*	probably null	Het
Crot	A	G	5: 8,993,575 (GRCm38)	Y16H	probably benign	Het
Cyld	T	G	8: 88,742,362 (GRCm38)	L587R	probably damaging	Het
Fam114a1	G	A	5: 65,031,395 (GRCm38)		probably null	Het
Fam89b	G	T	19: 5,729,369 (GRCm38)	D53E	probably benign	Het
Fig4	T	C	10: 41,267,786 (GRCm38)	M226V	probably benign	Het
Gm10722	A	T	9: 3,002,230 (GRCm38)	Y184F	probably damaging	Het
Hp	C	A	8: 109,579,021 (GRCm38)		probably benign	Het
Igsf9b	G	T	9: 27,334,304 (GRCm38)	R1189L	probably damaging	Het
Ilf3	A	G	9: 21,399,691 (GRCm38)	N620D	possibly damaging	Het
Jakmip3	A	C	7: 139,017,573 (GRCm38)	E228A	possibly damaging	Het
Kpna3	A	T	14: 61,370,517 (GRCm38)	I413K	probably damaging	Het
Letm1	A	T	5: 33,762,590 (GRCm38)	C202S	possibly damaging	Het
Lmod2	C	A	6: 24,604,135 (GRCm38)	Q370K	probably damaging	Het
Map4k5	T	C	12: 69,827,526 (GRCm38)		probably benign	Het
Mcidas	T	A	13: 112,997,585 (GRCm38)		probably benign	Het
Mme	A	G	3: 63,327,860 (GRCm38)		probably null	Het
Mrc1	T	C	2: 14,328,425 (GRCm38)	W1306R	probably damaging	Het
Mthfd1l	C	A	10: 4,030,716 (GRCm38)	Q473K	probably damaging	Het
Muc6	A	T	7: 141,648,066 (GRCm38)	C719*	probably null	Het
Nsun7	T	C	5: 66,283,601 (GRCm38)	I355T	possibly damaging	Het
Padi6	A	G	4: 140,729,003 (GRCm38)	L560P	probably damaging	Het
Parl	C	A	16: 20,282,790 (GRCm38)	A285S	possibly damaging	Het
Pclo	A	T	5: 14,793,834 (GRCm38)	M4795L	unknown	Het
Polr2f	A	G	15: 79,146,129 (GRCm38)	Y56C	probably damaging	Het
Rasgrp2	A	T	19: 6,404,383 (GRCm38)	H152L	probably damaging	Het
Rpl10l	T	C	12: 66,284,227 (GRCm38)	D44G	probably benign	Het
Slc25a16	A	G	10: 62,944,433 (GRCm38)		probably null	Het
Snrnp200	G	A	2: 127,232,472 (GRCm38)	E1411K	probably damaging	Het
Tanc2	G	A	11: 105,625,065 (GRCm38)	R3Q	probably damaging	Het
Tbc1d32	G	T	10: 56,201,959 (GRCm38)		probably null	Het
Tcf7l2	T	C	19: 55,919,627 (GRCm38)		probably benign	Het
Tnrc6c	G	T	11: 117,722,029 (GRCm38)	V498L	probably benign	Het
Tymp	G	A	15: 89,376,310 (GRCm38)	H102Y	probably damaging	Het
Wdr76	T	C	2: 121,535,497 (GRCm38)	S492P	probably benign	Het
Zc3h12d	T	C	10: 7,839,956 (GRCm38)	I41T	probably damaging	Het

Other mutations in Ccdc162

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01366:Ccdc162	APN	10	41,580,306 (GRCm38)	missense	possibly damaging	0.49
IGL01924:Ccdc162	APN	10	41,569,887 (GRCm38)	missense	probably damaging	1.00
IGL02504:Ccdc162	APN	10	41,552,388 (GRCm38)	missense	probably damaging	1.00
IGL02678:Ccdc162	APN	10	41,561,155 (GRCm38)	missense	probably damaging	0.99
IGL02955:Ccdc162	APN	10	41,561,127 (GRCm38)	missense	probably damaging	1.00
beeswax	UTSW	10	41,561,226 (GRCm38)	missense	possibly damaging	0.57
honeycomb	UTSW	10	41,644,641 (GRCm38)	missense	probably benign	0.35
FR4304:Ccdc162	UTSW	10	41,556,121 (GRCm38)	missense	possibly damaging	0.49
R0432:Ccdc162	UTSW	10	41,541,860 (GRCm38)	missense	probably benign	0.01
R0585:Ccdc162	UTSW	10	41,586,379 (GRCm38)	missense	probably benign	0.03
R0645:Ccdc162	UTSW	10	41,586,411 (GRCm38)	splice site	probably benign
R0731:Ccdc162	UTSW	10	41,579,143 (GRCm38)	missense	probably damaging	1.00
R1426:Ccdc162	UTSW	10	41,553,182 (GRCm38)	missense	possibly damaging	0.89
R1447:Ccdc162	UTSW	10	41,580,247 (GRCm38)	missense	probably damaging	1.00
R1712:Ccdc162	UTSW	10	41,539,431 (GRCm38)	missense	probably benign	0.35
R2138:Ccdc162	UTSW	10	41,581,297 (GRCm38)	missense	probably benign	0.15
R2351:Ccdc162	UTSW	10	41,555,972 (GRCm38)	critical splice donor site	probably null
R2394:Ccdc162	UTSW	10	41,569,898 (GRCm38)	missense	probably damaging	1.00
R2431:Ccdc162	UTSW	10	41,569,845 (GRCm38)	missense	probably benign
R2571:Ccdc162	UTSW	10	41,552,397 (GRCm38)	missense	probably damaging	1.00
R2873:Ccdc162	UTSW	10	41,655,099 (GRCm38)	missense	possibly damaging	0.68
R2926:Ccdc162	UTSW	10	41,561,207 (GRCm38)	start gained	probably benign
R2999:Ccdc162	UTSW	10	41,580,290 (GRCm38)	missense	probably benign	0.00
R3412:Ccdc162	UTSW	10	41,539,549 (GRCm38)	splice site	probably benign
R3712:Ccdc162	UTSW	10	41,587,379 (GRCm38)	missense	probably benign
R3736:Ccdc162	UTSW	10	41,589,568 (GRCm38)	splice site	probably null
R4112:Ccdc162	UTSW	10	41,656,328 (GRCm38)	missense	possibly damaging	0.77
R4557:Ccdc162	UTSW	10	41,587,388 (GRCm38)	missense	probably benign	0.01
R4580:Ccdc162	UTSW	10	41,561,140 (GRCm38)	missense	probably benign	0.02
R4685:Ccdc162	UTSW	10	41,681,686 (GRCm38)	missense	possibly damaging	0.89
R4837:Ccdc162	UTSW	10	41,673,867 (GRCm38)	missense	probably benign	0.00
R5155:Ccdc162	UTSW	10	41,579,151 (GRCm38)	missense	probably damaging	1.00
R5155:Ccdc162	UTSW	10	41,553,580 (GRCm38)	splice site	probably null
R5645:Ccdc162	UTSW	10	41,552,356 (GRCm38)	missense	probably benign	0.06
R5656:Ccdc162	UTSW	10	41,569,934 (GRCm38)	missense	probably benign	0.26
R5682:Ccdc162	UTSW	10	41,556,803 (GRCm38)	nonsense	probably null
R5808:Ccdc162	UTSW	10	41,655,504 (GRCm38)	missense	possibly damaging	0.62
R5909:Ccdc162	UTSW	10	41,561,115 (GRCm38)	missense	probably damaging	1.00
R6000:Ccdc162	UTSW	10	41,561,163 (GRCm38)	missense	possibly damaging	0.75
R6057:Ccdc162	UTSW	10	41,634,041 (GRCm38)	missense	possibly damaging	0.72
R6211:Ccdc162	UTSW	10	41,630,145 (GRCm38)	nonsense	probably null
R6264:Ccdc162	UTSW	10	41,694,468 (GRCm38)	missense	probably benign	0.31
R6329:Ccdc162	UTSW	10	41,663,151 (GRCm38)	missense	possibly damaging	0.76
R6349:Ccdc162	UTSW	10	41,694,400 (GRCm38)	missense	probably damaging	0.97
R6398:Ccdc162	UTSW	10	41,627,149 (GRCm38)	missense	probably damaging	1.00
R6453:Ccdc162	UTSW	10	41,550,825 (GRCm38)	missense	probably damaging	1.00
R6602:Ccdc162	UTSW	10	41,615,980 (GRCm38)	missense	probably benign	0.00
R6627:Ccdc162	UTSW	10	41,663,185 (GRCm38)	missense	probably damaging	1.00
R6722:Ccdc162	UTSW	10	41,644,641 (GRCm38)	missense	probably benign	0.35
R6750:Ccdc162	UTSW	10	41,561,226 (GRCm38)	missense	possibly damaging	0.57
R6968:Ccdc162	UTSW	10	41,673,844 (GRCm38)	missense	possibly damaging	0.55
R6970:Ccdc162	UTSW	10	41,615,958 (GRCm38)	missense	probably benign	0.03
R6989:Ccdc162	UTSW	10	41,581,353 (GRCm38)	missense	probably damaging	0.99
R7008:Ccdc162	UTSW	10	41,552,415 (GRCm38)	missense	probably damaging	1.00
R7135:Ccdc162	UTSW	10	41,673,859 (GRCm38)	missense	probably benign	0.00
R7139:Ccdc162	UTSW	10	41,666,721 (GRCm38)	missense	possibly damaging	0.49
R7224:Ccdc162	UTSW	10	41,561,191 (GRCm38)	missense	probably damaging	1.00
R7230:Ccdc162	UTSW	10	41,678,813 (GRCm38)	missense	probably damaging	1.00
R7256:Ccdc162	UTSW	10	41,556,001 (GRCm38)	missense	probably damaging	0.99
R7261:Ccdc162	UTSW	10	41,561,140 (GRCm38)	missense	probably benign	0.02
R7390:Ccdc162	UTSW	10	41,634,048 (GRCm38)	missense	probably benign
R7712:Ccdc162	UTSW	10	41,627,227 (GRCm38)	missense	possibly damaging	0.56
R7726:Ccdc162	UTSW	10	41,553,075 (GRCm38)	missense	probably benign	0.00
R7754:Ccdc162	UTSW	10	41,587,375 (GRCm38)	missense	probably damaging	1.00
R7764:Ccdc162	UTSW	10	41,690,113 (GRCm38)	missense	possibly damaging	0.95
R8053:Ccdc162	UTSW	10	41,644,581 (GRCm38)	missense	probably benign
R8088:Ccdc162	UTSW	10	41,623,414 (GRCm38)	missense	possibly damaging	0.68
R8094:Ccdc162	UTSW	10	41,612,868 (GRCm38)	missense	probably benign	0.02
R8097:Ccdc162	UTSW	10	41,634,119 (GRCm38)	missense	probably benign	0.03
R8321:Ccdc162	UTSW	10	41,634,033 (GRCm38)	missense	probably damaging	0.98
R8377:Ccdc162	UTSW	10	41,581,310 (GRCm38)	missense	probably benign	0.08
R8399:Ccdc162	UTSW	10	41,539,521 (GRCm38)	missense	probably damaging	1.00
R8669:Ccdc162	UTSW	10	41,552,356 (GRCm38)	missense	probably benign	0.06
R8772:Ccdc162	UTSW	10	41,630,037 (GRCm38)	missense	probably damaging	0.99
R8810:Ccdc162	UTSW	10	41,666,741 (GRCm38)	missense	probably benign	0.41
R8903:Ccdc162	UTSW	10	41,655,444 (GRCm38)	critical splice donor site	probably null
R8928:Ccdc162	UTSW	10	41,586,249 (GRCm38)	splice site	probably benign
R8950:Ccdc162	UTSW	10	41,598,511 (GRCm38)	missense	probably benign	0.00
R8960:Ccdc162	UTSW	10	41,553,182 (GRCm38)	missense	probably damaging	0.96
R8985:Ccdc162	UTSW	10	41,556,106 (GRCm38)	missense	probably damaging	1.00
R9071:Ccdc162	UTSW	10	41,581,178 (GRCm38)	nonsense	probably null
R9254:Ccdc162	UTSW	10	41,612,948 (GRCm38)	critical splice acceptor site	probably null
R9297:Ccdc162	UTSW	10	41,630,114 (GRCm38)	missense	probably benign
R9318:Ccdc162	UTSW	10	41,630,114 (GRCm38)	missense	probably benign
R9518:Ccdc162	UTSW	10	41,589,576 (GRCm38)	missense	probably damaging	1.00
R9525:Ccdc162	UTSW	10	41,683,226 (GRCm38)	missense	probably damaging	0.99
R9539:Ccdc162	UTSW	10	41,587,411 (GRCm38)	missense	possibly damaging	0.54
R9638:Ccdc162	UTSW	10	41,561,163 (GRCm38)	missense	probably benign	0.01
Z1176:Ccdc162	UTSW	10	41,654,997 (GRCm38)	missense	possibly damaging	0.84
Z1176:Ccdc162	UTSW	10	41,605,108 (GRCm38)	missense	possibly damaging	0.84
Z1176:Ccdc162	UTSW	10	41,553,131 (GRCm38)	missense	probably benign	0.00
Z1176:Ccdc162	UTSW	10	41,690,092 (GRCm38)	missense	probably benign	0.00
Z1177:Ccdc162	UTSW	10	41,683,195 (GRCm38)	missense	probably benign	0.00

Posted On

2013-06-28